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Articles 
Binh An Diep, Henry F. Chambers, Christopher J. Graber, John D. Szumowski, Loren G. Miller, Linda L. Han, Jason H. Chen, Felice Lin, Jessica Lin, Tiffany HaiVan Phan, Heather A. Carleton, Linda K. McDougal, Fred C. Tenover, Daniel E. Cohen, Kenneth H. Mayer, George F. Sensabaugh, and Françoise Perdreau-Remington Researchers have recently identified USA300, a clone of community-acquired, methicillin-resistant Staphylococcus aureus (MRSA) that is resistant to multiple antibiotics. Diep and colleagues demonstrate that the incidence of multidrug-resistant USA300 MRSA is highest in the areas of San Francisco where more male same-sex couples reside. The infection frequently manifests as an abscess or cellulitis in the buttocks, genitals, or perineum. Although multidrug-resistant USA300 MRSA infection might be sexually transmitted in this population, direct evidence on the mode of transmission is lacking.
Chi Pang Wen, Shan Pou Tsai, and Wen-Shen Isabella Chung In 1995, Taiwan implemented national health insurance. Wen and associates assessed its role in improving life expectancy and reducing health disparities in Taiwan. Differences in life expectancy between the healthiest and least healthy regions, defined as health disparities, were increasing before national health insurance and decreased afterward. However, disparities remained large. Whereas expenditures on health care increased, the percentage of gross domestic product spent on health care remained at 5% to 6%. Universal national health insurance alone may reduce health disparities, but only by a small amount in the absence of health system reform, which did not occur in Taiwan.
Rianne M. Rozendaal, Bart W. Koes, Gerjo J.V.M. van Osch, Elian J. Uitterlinden, Eric H. Garling, Sten P. Willemsen, Abida Z. Ginai, Jan A.N. Verhaar, Harrie Weinans, and Sita M.A. Bierma-Zeinstra Although many patients use glucosamine to treat osteoarthritis, available studies have reported inconsistent effects of glucosamine on symptoms and joint changes. In the first trial focusing on hip osteoarthritis, Rozendaal and colleagues randomly assigned 222 patients to glucosamine, 1500 mg/d, or placebo. After 2 years of treatment, they found no clinically significant effect on pain, function, or joint space narrowing. Whatever its effects on osteoarthritis in other joints, glucosamine sulfate was no better than placebo in reducing symptoms and progression of hip osteoarthritis.
Academia and Clinic
Isabelle Boutron, David Moher, Douglas G. Altman, Kenneth F. Schulz, Philippe Ravaud for the CONSORT Group This article supports the extension of CONSORT Statement in this issue. It is available online only.
Isabelle Boutron, David Moher, Douglas G. Altman, Kenneth F. Schulz, Philippe Ravaud for the CONSORT Group The conduct of randomized, controlled trials of nonpharmacologic treatments—such as surgery or behavioral interventions—presents specific challenges that clinical trial reports often do not address adequately, leaving readers unsure whether to believe the evidence. In order to strengthen the reporting of randomized trials of nonpharmacologic treatments, clinical epidemiologists and experts in this type of research developed additional reporting requirements to add to the CONSORT (Consolidated Standards of Reporting Trials) Statement. This article describes these additional standards.
Reviews
John H. Newman, John A. Phillips, III, and James E. Loyd When pulmonary arterial hypertension (PAH) is not caused by other illnesses, its etiology is a mystery that is now beginning to be solved. Inherited susceptibility to PAH occurs in families, and researchers report a strong association between PAH and mutations in a receptor in the gene for a transforming growth factor that regulates cell growth (transforming growth factor-β [TGF-β]). Newman and colleagues describe the research that led to this discovery and treatment opportunities. The evidence increasingly suggests that idiopathic PAH is caused by an imbalance of TGF-β receptor signals that promote or retard vascular intimal proliferation.
Aine M. Kelly, Ben Dwamena, Paul Cronin, Steven J. Bernstein, and Ruth C. Carlos Contrast-induced nephropathy is a common cause of acute renal failure in hospitalized patients. Clinicians use many drugs to reduce the risk for the condition, including N-acetylcysteine, theophylline, fenoldopam, dopamine, furosemide, mannitol, and bicarbonate. In their meta-analysis of 33 trials involving 3622 patients, Kelly and colleagues found the strongest evidence for N-acetylcysteine, mannitol, and theophylline when compared with periprocedural hydration alone. However, available studies examined laboratory measures of renal function rather than clinical end points.
Editorials
Rachel Gorwitz, Scott K. Fridkin, and Kimberly A. Workowski In this issue, Diep and colleagues explore the epidemiology of methicillin-resistant Staphylococcus aureus USA300 isolates that contain the conjugative plasmid pUSA03. They suggest that men who have sex with men may be at increased risk for this infection. However, although evidence suggests that the infection is sexually transmitted, it is not strong enough to prove this hypothesis.
Karen Davis and Andrew T. Huang In this issue, Wen and colleagues analyze trends in life expectancy in Taiwan before and after the introduction of national health insurance. Their results suggest a substantial payoff for investing in health insurance for all but also indicate the importance of a broad, systemic approach targeting the root causes of disease, such as smoking and obesity.
Johannes W.J. Bijlsma and Floris P.J.G. Lafeber In this issue, Rozendaal and colleagues report what is apparently the first randomized trial on the effect of glucosamine sulfate on hip osteoarthritis. They concluded that glucosamine sulfate was no better than placebo in reducing symptoms and progression. However, osteoarthritis is a heterogeneous disease, and glucosamine may ameliorate symptoms in the joints. Still, the bottom line is that glucosamine is unproven therapy for osteoarthritis.
On Being a Doctor
Faith Fitzgerald I tell my patients, residents, and students that they should call me if they need me. They are not an interruption to my work; they are my work. In this sense, I can't be "bothered" by them. But a system and a culture designed to protect doctors from their patients assume I am bothered, and so gives that same impression to those trying to reach me. This really bothers me.
Letters Agranulocytosis Induced by Nonchemotherapy Drugs
Analyzing the Results of the Treating to New Targets Study
Cystatin C, Renal Function, and Cardiovascular Risk
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