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Articles 
William S. Yancy, Jr., Maren K. Olsen, John R. Guyton, Ronna P. Bakst, and Eric C. Westman Patients on a low-carbohydrate diet had better adherence and lost more weight than those on a low-fat diet. During active weight loss, serum triglyceride levels and high-density lipoprotein cholesterol levels improved more with the low-carbohydrate diet than with the low-fat diet.
Linda Stern, Nayyar Iqbal, Prakash Seshadri, Kathryn L. Chicano, Denise A. Daily, Joyce McGrory, Monica Williams, Edward J. Gracely, and Frederick F. Samaha Participants on a low-carbohydrate diet had better results overall at 1 year than those on a low-fat, restricted-calorie diet. Weight loss was the same in the 2 groups, but patients on the low-carbohydrate diet had less atherogenic dyslipidemia and better glycemic control.
Colleen Hadigan, Sigal Yawetz, Abraham Thomas, Fiona Havers, Paul E. Sax, and Steven Grinspoon Recent studies of HIV-infected patients suggest that disordered peroxisome proliferator–activated receptor-
Improving Patient Care
Jonathan R. Nebeker, Paul Barach, and Matthew H. Samore The terminology used to describe patient harm associated with medications is confusing. This paper uses the case of a patient with multiple adverse drug events to clarify key terms, such as adverse event, adverse drug reaction, adverse drug event, medication error, and side effect.
Reviews
Shelley R. Salpeter, Thomas M. Ormiston, and Edwin E. Salpeter Patients with asthma who use ß2-agonists regularly for at least 1 week develop tolerance to the drug's bronchodilator and nonbronchodilator effects. Regular ß2-agonist use may be associated with poorer disease control than that achieved with placebo.
In the Balance
Mitchell Charap In the 25 years that I have been teaching in New York, graduate medical education has changed a great deal. Clearly much has improved. However, the recent restrictions in work hours are an ominous development because of their effect on both patient care and the education of our future physicians.
Kelley M. Skeff, Stephen Ezeji-Okoye, Peter Pompei, and Stanley Rockson The new regulations for resident work hours, which are the most dramatic recent innovation to calibrate trainees' work hours, are one step in a long evolutionary process of change in medical education. We believe that the positive effects of the regulations are just the beginning.
Melinda E. Glines As I approach the halfway point of my residency, I cannot imagine why anyone coming directly out of residency would want to practice full-time, except out of financial necessity. Residency training, even in the most humane of programs, is such an all-absorbing experience that I, too, crave time to rest and reflect.
Clinical Guidelines
U.S. Preventive Services Task Force* The U.S. Preventive Services Task Force concludes that the evidence is insufficient to recommend for or against routine screening by primary care clinicians to detect suicide risk in the general population.
Bradley N. Gaynes, Suzanne L. West, Carol A. Ford, Paul Frame, Jonathan Klein, and Kathleen N. Lohr Because of the complexity of studying the risk for suicide and the paucity of well-designed research studies, we have limited evidence to guide the primary care clinician's assessment and management of suicide risk.
Editorials
Walter C. Willett In the context of the 2 studies in this issue on low-carbohydrate diets, what advice can we offer our patients who want to lose weight? We can encourage overweight patients to experiment with methods for weight control, including reduced-carbohydrate diets, as long as they emphasize healthy sources of fat and protein and incorporate regular physical activity. Patients should focus on finding ways to eat that they can maintain indefinitely rather than seeking diets that promote rapid weight loss.
Steven A. Schroeder Because the regulation limiting work hours for residents is a simple "fix" for a complicated problem and because lifestyle issues are increasingly important, we should be prepared for further attacks on the medical residency system. How medicine chooses to balance young physicians' increasingly urgent calls for a decent lifestyle with its ancient tradition of service will say a lot about what kind of a profession it will become.
On Being a Doctor
Lauren Plante I was an obstetrician, and then I was a mother, until I had to give up the one for the other.
Gale Burstein Before my own experience with postpartum depression, I was guilty of assuming stereotypes about mental health disorders. Knowing what I know today, I wonder why I had those beliefs. I wonder why more physicians are unable to be sympathetic to their colleagues' harsh realities of new motherhood and why more physicians do not thoughtfully suggest to an unhappy new-mother colleague that she may benefit from mental health services.
Letters How do Physicians Think about Successful Aging?
Cost-Effectiveness of Mammography for Older Women
Saving Office Practice
Management Options for Patients with Ulcer Hemorrhage
High-Dose Vitamin C and Iron Overload
Actual versus Perceived Workload for House Officers: Black Cloud Looming?
Virulence Factors Predict Escherichia coli Colonization Patterns among Human and Animal Household Members
Epinephrine-Secreting Pheochromocytoma Presenting with Cardiogenic Shock and Profound Hypocalcemia
Stuart G. Finder
Avery S. Hart
Jennifer Fisher Wilson
Jack Coulehan
George N. Braman
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