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Articles 
Patrick Y. Lee, David B. Matchar, Dennis A. Clements, Joel Huber, John D. Hamilton, and Eric D. Peterson Vaccination is cost-beneficial in most influenza seasons in healthy working adults. Although the benefits of antiviral therapy for persons with influenza infection appear to justify its cost, head-to-head trials of the various antiviral therapies are needed to determine the optimal treatment strategy.
Carlo Salvarani, Mauro Silingardi, Angelo Ghirarduzzi, Giovanni Lo Scocco, PierLuigi Macchioni, GianLuigi Bajocchi, Marco Vinceti, Fabrizio Cantini, Ido Iori, and Luigi Boiardi Evidence on ultrasonography of any halo or a halo 1 mm or greater in thickness around temporal arteries only modestly increased the probability of biopsy-proven giant-cell arteritis but did not improve the diagnostic accuracy of a careful physical examination.
Ole Kirk, Peter Reiss, Caterina Uberti-Foppa, Markus Bickel, Jan Gerstoft, Christian Pradier, Ferdinand W. Wit, Bruno Ledergerber, Jens D. Lundgren, Hansjakob Furrer for Seven European HIV Cohorts* Maintenance therapy against previous infection with cytomegalovirus, Mycobacterium avium complex, Toxoplasma gondii, or Cryptococcus neoformans in patients with HIV infection can be interrupted after sustained CD4 count increases to greater than 200 (or possibly 100 to 200) x 106 cells/L for at least 6 months after the start of potent antiretroviral therapy.
Brief Communications
Mark A. Crowther, James D. Douketis, Terri Schnurr, Luigi Steidl, Valentina Mera, Carolina Ultori, Achille Venco, and Walter Ageno Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in asymptomatic patients who had supratherapeutic international normalized ratio values while receiving warfarin.
Academia and Clinic
Kimberly A. Workowski, William C. Levine, and Judith N. Wasserheit Effective clinical management of sexually transmitted diseases is a strategic common element in efforts to prevent HIV infection and to improve reproductive and sexual health. This paper presents new recommendations from the 2002 CDC Guidelines for the Treatment of Sexually Transmitted Diseases in the context of current disease trends and public health.
R Graham Barr, David M. Nathan, James B. Meigs, and Daniel E. Singer This paper discusses tests of glycemia for the diagnosis of type 2 diabetes mellitus, with particular reference to the 1997 diagnostic criteria of the American Diabetes Association.
Reviews
Linda L. Humphrey, Benjamin K.S. Chan, and Harold C. Sox This meta-analysis discusses postmenopausal hormone replacement therapy and the primary prevention of cardiovascular disease.
Editorials
Jonathan E. Kaplan, Henry Masur, and King K. Holmes In this issue, Kirk and colleagues provide important data on discontinuation of secondary prophylaxis after episodes of cytomegalovirus disease, Mycobacterium avium complex disease, toxoplasmosis encephalitis, and extrapulmonary cryptococcosis. However, questions remain about which patients can most safely discontinue secondary prophylaxis.
Alan M. Garber, Cynthia Mulrow, and Harold C. Sox Advances in diagnostic testing have been among the most significant medical innovations of recent years, but they have not simplified the choice of diagnostic strategies. The need for an evidence-based approach to such choices has never been greater. With the article by Barr and colleagues, this issue inaugurates a series on the selection and interpretation of diagnostic tests.
Christine Laine The early stoppage and release of the main results of the estrogen plus progestin component of the Women's Health Initiative have caused millions of postmenopausal women to confront their medicine cabinets in confusion. In this issue, Humphrey and colleagues summarize data that pointed toward a sizable reduction in the risk for coronary events in women who took hormone replacement therapy after menopause.
On Being a Doctor
Kathie Kadri It was 11 December 1979, just past dawn. He was across the room from me, in an incubator because of a difficult birth. The most beautiful newborn I had ever seen.
On Being a Patient
John L. McClenahan "Doctor B. just walked in," my receptionist said. "He wants to see you." So, I said to myself, he finally made it. Five missed appointments in 3 months. I finished my coffee, got up, and faced him across a crowded waiting room.
Letters Delirium at the End of Life
Clinical Trials Testing the Homocysteine Hypothesis
Infliximab Therapy for Complicated Sarcoidosis
Colitis Associated with Variant Clostridium difficile
Effect of Angiotensin-Converting Enzyme Inhibitors on Progression of Nondiabetic Renal Disease
Ischemic Colitis Associated with Anti-ß2 Glycoprotein-I Antibody
Correction: Angiotensin-Converting Enzyme Inhibitors and Progression of Nondiabetic Renal Disease
John J. Condemi
David F. Penson
Brigid Kane
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