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Articles 
Erin G. Stone, Sally C. Morton, Marlies E. Hulscher, Margaret A. Maglione, Elizabeth A. Roth, Jeremy M. Grimshaw, Brian S. Mittman, Lisa V. Rubenstein, Laurence Z. Rubenstein, and Paul G. Shekelle Rates of adult immunization and cancer screening are most likely to improve when a health care organization supports performance of these activities through organizational changes in staffing and clinical procedures. Involving patients in self-management through patient financial incentives and reminders is also likely to positively affect performance.
Sylvia K. Oboler, Allan V. Prochazka, Ralph Gonzales, Stanley Xu, and Robert J. Anderson Public desire for a comprehensive annual physical examination is high across the United States and is sensitive to financial charges.
Geraldine M. McQuillan, Deanna Kruszon-Moran, Adamadia Deforest, Susan Y. Chu, and Melinda Wharton A substantial proportion of adults in the United States do not have antibody levels that are protective against diphtheria and tetanus. Although the recommended vaccine is a combination of tetanus and diphtheria, only 63% of adults in this study with protective antibody to tetanus also had protective antibody to diphtheria.
Brief Communications
Pietro Muretto, Emanuele Angelucci, and Guido Lucarelli In some patients in whom bone marrow transplantation has cured thalassemia, cirrhosis may be reversible after iron removal treatment.
Academia and Clinic
LaVera M. Crawley, Patricia A. Marshall, Bernard Lo, Barbara A. Koenig for the End-of-Life Care Consensus Panel* Differences in beliefs, values, and traditional health care practices are of particular relevance at the end of life. Physicians need to be sensitive to cultural differences and to develop the skills necessary to work with patients from diverse backgrounds.
Reviews
Jill Miller, Benjamin K.S. Chan, and Heidi D. Nelson Postmenopausal estrogen replacement is associated with an increased risk for venous thromboembolism, and this risk may be highest in the first year of use.
Perspectives
Samuel Z. Goldhaber Echocardiography is useful for identifying patients with pulmonary embolism who may have a poor prognosis. Further research will clarify and more precisely define the utility and limitations of echocardiography in the management of pulmonary embolism.
Editorials
Christine Laine In this issue, Oboler and colleagues report that many Americans believe in the necessity of annual physical examinations. In addition, Stone and associates show that planned visits for prevention were potent components of interventions that increased the use of preventive services. Annual examinations provide the opportunity to plug cracks in the system and assure that patients are getting indicated preventive care.
On Being a Doctor
Mack Lipkin, Jr. 8:50 a.m.: Our pregnant chief resident says, "Did you see the World Trade Center is smoking?"
Letters Principles of Appropriate Antibiotic Use: Acute Pharyngitis
Principles of Judicious Antibiotic Use: Acute Rhinosinusitis
Principles of Judicious Antibiotic Use: Nonspecific Upper Respiratory Tract Infections
Physicians and Joint Negotiations
Thalidomide and Venous Thrombosis
Correction: Mixed Hepatocellular–Cholestatic Liver Injury after Pioglitazone Therapy
Brent A. Bauer
Keyoumars Soltani
Jason David Eubanks
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