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Articles 
Jinan B. Saaddine, Michael M. Engelgau, Gloria L. Beckles, Edward W. Gregg, Theodore J. Thompson, and K.M. Venkat Narayan According to U.S. data collected from 1988 through 1995, a gap exists between recommended diabetes care and the care patients actually receive. These data offer a benchmark for monitoring changes in diabetes care.
Michael P. Stern, Ken Williams, and Steven M. Haffner Persons at high risk for diabetes mellitus are better identified by using a simple prediction model than by relying exclusively on the results of a 2-hour oral glucose tolerance test. Although adding the 2-hour glucose variable to the model enhanced prediction, the resulting slight improvement entails greater cost and inconvenience.
Nicolas Rodondi, Roger Darioli, Albert-Adrien Ramelet, Daniel Hohl, Vincent Lenain, Jean Perdrix, Vincent Wietlisbach, Walter F. Riesen, Thomas Walther, Laurent Medinger, Pascal Nicod, Béatrice Desvergne, and Vincent Mooser Persons who develop hypertriglyceridemia during isotretinoin therapy for acne, as well as their parents, are at increased risk for future hyperlipidemia and the metabolic syndrome.
Brief Communications
Joya T. Favreau, Mina L. Ryu, Glenn Braunstein, Greg Orshansky, Sean S. Park, Gary L. Coody, Lori A. Love, and Tse-Ling Fong Seven patients developed acute hepatotoxicity within 3 months of using LipoKinetix, a weight loss supplement. Despite extensive evaluations, no other cause for hepatotoxicity could be identified in these patients.
Academia and Clinic
Michael H. Cohen and David M. Eisenberg Physicians are increasingly grappling with medical liability issues as complementary and integrative health care practices are made available in conventional medical settings. This article proposes a framework in which physicians can assess potential malpractice liability issues in counseling patients about complementary and integrative therapies.
Reviews
Giuseppe Remuzzi, Piero Ruggenenti, and Norberto Perico Certain renal diseases seen in clinical practice have a rapid course that soon causes irreversible end-stage renal failure caused by complete structural damage. These diseases, however, are rare. The more common nephropathies progress more slowly but still evolve to end-stage renal failure. A multimodal approach that centers on reducing or removing all risk factors associated with renal disease progression may decrease the time to remission for most patients with proteinuric nephropathies.
Clinical Guidelines
Kevin Imrie, Rosmin Esmail, Ralph M. Meyer and the Members of the Hematology Disease Site Group of the Cancer Care Ontario Practice Guidelines Initiative* The Hematology Disease Site Group of the Cancer Care Ontario Practice Guidelines Initiative has systematically reviewed the published literature and, through a consensus process, developed an evidence-based practice guideline assessing the role of stem-cell transplantation in patients with multiple myeloma. This paper discusses the six recommendations contained in the guideline.
Editorials
James D. Lewis and Brian L. Strom In this issue, Favreau and colleagues report on cases of hepatotoxicity in users of the dietary supplement LipoKinetix. This and other recent reports of adverse outcomes associated with supplement use highlight two important issues that merit further consideration: 1) regulation and safety of dietary supplements and 2) safety surveillance.
Letters Osteoarthritis and Knee Pain
Pseudoaccountability
Long-Term Prediction of Coronary Heart Disease in Young Men
Appropriate Antibiotic Use for Acute Pharyngitis
Cardiovascular Outcomes and Renal Disease
William of Occam and Occam's Razor
Correction: Cost-Effectiveness of Statins in Older Patients with Myocardial Infarction
Kavita Nanda
John Hansen-Flaschen
Linda Gundersen
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