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Articles 
Craig G. Crandall, Wanpen Vongpatanasin, and Ronald G. Victor In humans, impaired heat dissipation is a major mechanism by which cocaine elevates body temperature. When healthy, cocaine-naive persons are subjected to passive heating, pretreatment with even a small dose of intranasal cocaine impairs sweating and cutaneous vasodilation (the major autonomic adjustments to thermal stress) and heat perception (the key trigger for behavioral adjustments).
Nathorn Chaiyakunapruk, David L. Veenstra, Benjamin A. Lipsky, and Sanjay Saint Bloodstream infections are significantly reduced in patients with central vascular lines who receive chlorhexidine gluconate versus povidone-iodine for skin site disinfection. Use of chlorhexidine gluconate rather than povidone-iodine for catheter-site care is a simple and effective means of reducing vascular catheter–related infections.
Pamela L. Owens, Elizabeth H. Bradley, Sarah M. Horwitz, Catherine M. Viscoli, Walter N. Kernan, Lawrence M. Brass, Philip M. Sarrel, and Ralph I. Horwitz Self-reported and performance-based measures of function can differ in women who have experienced a recent cerebrovascular event. Although more difficult to collect, results of a performance-based measure may provide important information about long-term health outcomes.
Brief Communications
Eric J. Thomas, Stuart R. Lipsitz, David M. Studdert, and Troyen A. Brennan Estimates of adverse event rates from medical record review, including those reported by the U.S. Institute of Medicine in its 2000 report on medical errors, are highly sensitive to the degree of consensus and confidence among reviewers.
Academia and Clinic
Ted J. Kaptchuk This essay looks at the placebo effect of alternative medicine as a distinct entity by reviewing current knowledge about the placebo effect and how it may pertain to alternative medicine. Five components of the placebo effect—patient, practitioner, patient–practitioner interaction, nature of the illness, and treatment and setting—are examined.
Mark R. Chassin and Elise C. Becher Among all types of medical errors, cases in which the wrong patient undergoes an invasive procedure are sufficiently distressing to warrant special attention. Nevertheless, institutions underreport such procedures, and the medical literature contains few discussions about them. This article examines the case of a patient who was mistakenly taken for another patient's invasive electrophysiology procedure.
Reviews
Nasia Safdar and Dennis G. Maki Recent years have witnessed a rapidly growing crisis in antimicrobial resistance, especially among microorganisms that cause nosocomial infection. To better understand common risk factors among multiresistant organisms, this review explores risk factors for nosocomial infection with methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococcus, Clostridium difficile, extended-spectrum ß-lactamase–producing gram-negative bacilli, and Candida.
Perspectives
Lynn A. Jansen and Daniel P. Sulmasy This paper examines the various ways that the terms terminal sedation and refusal of hydration and nutrition have been used in the medical literature.
Editorials
Robert M. Wachter, Kaveh G. Shojania, Sanjay Saint, Amy J. Markowitz, and Mark Smith In this issue, with the paper by Chassin and Becher, Annals launches a new series, "Quality Grand Rounds."
Letters Tobacco Use in HIV-Infected Women
Effects of Pravastatin in the Elderly
The Heartbreak of Drug Pricing
Molecular Genetic Evidence of an Association between Nasal Polyposis and the Peutz–Jeghers Syndrome
Josbert J. Keller, Anne Marie Westerman, Felix W.M. de Rooij, J.H. Paul Wilson, Herman van Dekken, Francis M. Giardiello, Marian A.J. Weterman, and G. Johan A. Offerhaus Correction: Update in Infectious Diseases
Robert H. Gifford
Sangnya Patel
Jack Coulehan
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