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Articles 
Francine Grodstein, JoAnn E. Manson, and Meir J. Stampfer The risk for recurrent major coronary events seems to increase among women with previous coronary disease who have used hormone replacement therapy for a short period but appears to decrease with longer-term hormone use.
Kalpana Gupta, Thomas M. Hooton, Pacita L. Roberts, and Walter E. Stamm A strategy in which a health care professional provided a prescription for self-diagnosis and self-treatment of urinary tract infections (UTIs) in young women with a recent history of uncomplicated UTIs seemed safe and feasible.
Edward L. Murphy, Ann C. Collier, Leslie A. Kalish, Susan F. Assmann, Michael F. Para, Timothy P. Flanigan, Princy N. Kumar, Letty Mintz, Frances R. Wallach, George J. Nemo for the Viral Activation Transfusion Study Investigators* The data from this study support an independent reduction in mortality and opportunistic events attributable to highly active antiretroviral therapy (HAART), even in patients with very advanced HIV disease. However, in patients with cytomegalovirus infection or disease, HAART may not reduce the rate of new cytomegalovirus events.
Brief Communications
Arthur M.F. Yee and Mark B. Pochapin Infliximab therapy was successful in a patient with sarcoidosis. Tumor necrosis factor-
Academia and Clinic
David J. Casarett, Sharon K. Inouye for the American College of Physicians–American Society of Internal Medicine End-of-Life Care Consensus Panel* This consensus paper uses a case-based format that begins with an overview of the definition and presentation of delirium. The authors suggest strategies for diagnosis, with attention to the unique challenges in diagnostic work-up for patients near the end of life, and they review therapeutic options.
Reviews
Kalpana Gupta, Thomas M. Hooton, and Walter E. Stamm The authors highlight the problem of antimicrobial resistance in acute uncomplicated community-acquired urinary tract infection (UTI), summarize the few available data on clinical outcomes associated with in vitro resistance, and outline recommendations for empirical treatment of uncomplicated UTI in a period of evolving antimicrobial resistance.
Editorials
Andrew Herxheimer Gupta and colleagues' article in this issue shows that many women with a previous urinary tract infection can learn to diagnose and manage a subsequent episode themselves. This promising finding prompts additional questions: How can we build on this experience and give greater responsibility and autonomy to more patients? What diseases and conditions offer the greatest opportunities, rewards, and likelihood of success?
Harold Sox A journal that responds to the needs of its readers will develop a sense of community enterprise that engages reader, author, reviewer, and staff alike. Developing ways to listen better will be among our highest priorities in the next few months.
On Being a Doctor
Bonnie Salomon You might think it odd to care about a broken stethoscope—a piece of steel and plastic tubing, an instrument, a mere tool. You might think it overly sentimental to care about a 15-year-old stethoscope, now broken, a dud, not able to transmit the harshest breath sounds or murmur.
On Being a Patient
Carol Udycz I am the research participant. I am part of your team. I trust that your guidance will provide me with innovative treatment plans that will help me be part of the cure. With your help, I'm going to keep on fighting as if I have every chance of winning.
Letters In Defense of a Department of Geriatrics
Placebo-Controlled Trials
Update in Infectious Diseases
Testosterone and Resistance Training in AIDS
Garlic for Total Cholesterol Reduction
Wine and Mortality
Smoking and Abnormalities in Renal Function
Kava Hepatotoxicity
Medication Assistance Programs
Acute Renal Failure Related to High-Dose Celecoxib
Usefulness of Online Mendelian Inheritance in Man in Clinical Practice
Idiopathic Thrombocytopenic Purpura in a 101-Year-Old Woman
Correction: Physicians and Joint Negotiation
Correction: Risk Factors for Coronary Heart Disease in Men 18 to 39 Years of Age
Thomas G. Tape
Christian Guilleminault
Phillip J. Cozzi
George N. Braman
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may be an important mediator of clinical disease in sarcoidosis and could be an attractive target for therapeutic intervention. However, infliximab may cause adverse effects associated with cytokine cascade manipulation.