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Articles 
Ananda S. Prasad, James T. Fitzgerald, Bin Bao, Frances W.J. Beck, and Pranatharthi H. Chandrasekar Use of zinc lozenges was associated with reduced duration and severity of cold symptoms, especially cough. Improvement in clinical symptoms with zinc treatment may be related to a decrease in proinflammatory cytokine levels; in this study, however, the observed changes in cytokine levels did not significantly differ between zinc and placebo groups.
Heather M. Arthur, Charlotte Daniels, Robert McKelvie, Jack Hirsh, and Bonnie Rush The waiting period for elective procedures, such as coronary artery bypass grafting, may be used to enhance in-hospital and early-phase recovery, improving patients' functional abilities and quality of life while reducing their hospital stay.
Elif Arioglu, Jennifer Duncan-Morin, Nancy Sebring, Kristina I. Rother, Nicole Gottlieb, Jay Lieberman, David Herion, David E. Kleiner, James Reynolds, Ahalya Premkumar, Anne E. Sumner, Jay Hoofnagle, Marc L. Reitman, and Simeon I. Taylor Troglitazone therapy improved metabolic control and increased body fat in patients with lipoatrophic diabetes. The substantial benefits of troglitazone must be balanced against the risk for hepatotoxicity, which can occur relatively late in the treatment course.
Brief Communications
Voravit Ratanatharathorn, Erik Carson, Christopher Reynolds, Lois J. Ayash, John Levine, Gregory Yanik, Samuel M. Silver, James L.M. Ferrara, and Joseph P. Uberti The efficacy of rituximab for immune-mediated thrombocytopenia in the patient described here suggests that this drug may have activity in other autoimmune diseases or chronic graft-versus-host disease.
Paulo F. Barroso, Mauro Schechter, Phalguni Gupta, Maria F. Melo, Marcello Vieira, Fernanda C. Murta, Yeda Souza, and Lee H. Harrison Antiretroviral therapy reduces shedding of HIV in semen; in turn, this reduction probably decreases HIV transmissibility. However, a substantial proportion of patients may still be infectious and may harbor drug-resistant strains of the virus.
In the Balance
William R. Hazzard Given the progressive aging of the U.S. population, it may seem natural for geriatrics to become a separate specialty with its own academic department. The author recommends an alternative—a center on aging or pan-institutional program that is firmly anchored in the department of internal medicine.
Christine K. Cassel The author argues the case for departments of geriatric medicine as institutional structures that can advance research, improve teaching, and enhance patient care.
Editorials
Norman A. Desbiens Prasad and colleagues' study in this issue points to an important, often overlooked issue in randomized, double-blind, placebo-controlled trials: testing the participants' assessment of whether they are receiving placebo or active drug.
Om P. Ganda In this issue, Arioglu and colleagues report that troglitazone led to better metabolic control and increased body fat in patients with lipoatrophic diabetes. What are the mechanisms of the efficacy of troglitazone in these patients?
Letters Economic Sanctions and Embargoes
Histologic Improvement of Fibrosis in Patients with Hepatitis C and Sustained Response to Interferon Therapy
Radiofrequency Ablation of Metastatic Lesions in Adrenocortical Cancer
The Pet Separation Syndrome
Tobacco Awareness Curricula in Medical Schools
Laryngopharyngeal Examination: An Important but Not-So-New Role of Upper Gastrointestinal Endoscopy
Glutaraldehyde Colitis: A Complication of Screening Flexible Sigmoidoscopy in the Primary Care Setting
Nicholas J. Lekas
Leonard B. Seeff
Linda Gundersen
Deborah Gesensway
Anna B. Reisman
Edward V. Spudis
John G. Bartlett Topics covered in this Update include antimicrobial resistance, community-acquired pneumonia, and HIV infection. | ||||||||||||||||||||||||||||||||||||||||||||||||||
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