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Articles 
Deborah Grady, Nanette K. Wenger, David Herrington, Steven Khan, Curt Furberg, Donald Hunninghake, Eric Vittinghoff, Stephen Hulley for the Heart and Estrogen/progestin Replacement Study Research Group Postmenopausal therapy with estrogen plus progestin increases risk for venous thromboembolism in women with coronary heart disease. This risk should be considered when the risks and benefits of therapy are being weighed.
Christina C. Wee, Ellen P. McCarthy, Roger B. Davis, and Russell S. Phillips Compared with normal-weight women, overweight and obese women were less likely to be screened for cervical and breast cancer with Papanicolaou smears and mammography, even after adjustment for other known barriers to care. Because overweight and obese women have higher rates of death from cervical and breast cancer, they should be targeted for increased screening.
Nina A. Bickell and Mark R. Chassin Data from tumor registries were found to provide accurate measures for hospital-based surgical treatments but not for outpatient treatment. Unverified tumor registry data should not be used to measure quality of care.
Brief Communications
J. Carlos Ayus, Joseph Varon, and Allen I. Arieff In seven healthy marathon runners, noncardiogenic pulmonary edema was associated with hyponatremic encephalopathy. The condition may be fatal if it is not diagnosed, and it can be successfully treated with hypertonic NaCl.
Academia and Clinic
William L. Greene, John Concato, and Alvan R. Feinstein Many studies of clinical equivalence do not set boundaries for equivalence. Claims of "difference" or "similarity" are often made not by thoughtful examination of the data but by tests of statistical significance that are frequently misapplied or accompanied by inadequate sample sizes. These methodologic flaws can lead to false claims, inconsistencies, and harm to patients.
Reviews
Arshad H. Malik and William M. Lee This review focuses on specific treatments available for hepatitis B and discusses the replication of the hepatitis B virus to facilitate understanding of the mechanism of action of nucleoside analogues.
Position Papers
Vincenza Snow, Steven Lascher, Christel Mottur-Pilson for the American College of Physicians-American Society of Internal Medicine*. This guideline answers the following questions: What evidence supports the benefits of pharmacologic treatment of depression? What are the data on the efficacy and side effects of newer compared with older pharmacotherapies? How can the evidence assist physicians and patients in making informed decisions about treatment options?
John W. Williams, Jr., Cynthia D. Mulrow, Elaine Chiquette, Polly Hitchcock Noël, Christine Aguilar, and John Cornell Newer antidepressants are clearly effective for treating depressive disorders in diverse settings. Because of similar efficacy, both newer and older antidepressants should be considered when treatment decisions are being made. Better information is urgently needed on the efficacy of newer antidepressants in patients with nonmajor depression and in special populations.
Editorials
Russell Harris The study by Wee and colleagues in this issue highlights the need for new approaches to assessing quality of care.
Robert A. Kyle Multiple myeloma is a difficult and frustrating disease to treat. Although bisphosphonates are clearly not a panacea, they represent an advance in skeletal benefit and symptom control that is meaningful for both patients and physicians.
On Being a Doctor
Christine S. Seibert Sometimes, after a particularly difficult day, I sift through my box to be reminded and sustained by these special encounters in my journey as a physician.
Letters Risk for Obstructive Sleep Apnea
Nonfasting Plasma Total Homocysteine Level and Mortality
Therapeutic Plasma Exchange
Quotations on the Wall
Potential New Cardiovascular Risk Factors
Serum Cholesterol and Low-Density Lipoprotein Cholesterol Levels as Predictors of Response to Interferon Therapy for Chronic Hepatitis C
Small Dense Low-Density Lipoprotein in Japanese Men with Coronary Artery Disease
David W. Bates and Atul A. Gawande This essay discusses several books on the continuing discovery of the frequency and effect of medical errors.
Eleanor Z. Wallace
Patrick S. Romano
Harold E. Carlson
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