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Articles 
Ming Wei, Larry W. Gibbons, James B. Kampert, Milton Z. Nichaman, and Steven N. Blair Low cardiorespiratory fitness and physical inactivity were found to be independent predictors of all-cause mortality in men with type 2 diabetes. Physicians should encourage patients with this disease to participate in regular physical activity and improve their cardiorespiratory fitness.
Rebecca E. Rudolph, Thomas L. Vaughan, Barry E. Storer, Rodger C. Haggitt, Peter S. Rabinovitch, Douglas S. Levine, and Brian J. Reid The risk for esophageal adenocarcinoma in patients with short-segment Barrett esophagus was not substantially lower than that in patients with longer segments. Although the findings of this study suggest a small increase in risk for neoplastic progression with increasing segment length, additional follow-up is needed to determine whether the patterns of risk occurred by chance or represent true differences.
Jean-Yves Fagon, Jean Chastre, Michel Wolff, Claude Gervais, Sylvie Parer-Aubas, François Stéphan, Thomas Similowski, Alain Mercat, Jean-Luc Diehl, Jean-Pierre Sollet, Alain Tenaillon for the VAP Trial Group* In patients suspected of having ventilator-associated pneumonia, an invasive diagnostic strategy based on use of fiberoptic bronchoscopy improved the survival rate, decreased antibiotic use, and was associated with earlier attenuation of organ dysfunction compared with a noninvasive strategy.
Brief Communications
Nathalie Costedoat-Chalumeau, Zahir Amoura, Guy Aymard, Odile Sevin, Bertrand Wechsler, Patrice Cacoub, Le Thi Huong Du, Bertrand Diquet, Annick Ankri, and Jean-Charles Piette This study found that the action of oral anticoagulants is potentiated by intravenous high-dose methylprednisolone. The international normalized ratio should be monitored daily during concomitant administration of these medications.
Meenakshi Khatta, Barbara S. Alexander, Cathy M. Krichten, Michael L. Fisher, Ronald Freudenberger, Shawn W. Robinson, and Stephen S. Gottlieb In a randomized, controlled trial, coenzyme Q10 did not affect ejection fraction, peak oxygen consumption, or exercise duration in patients with congestive heart failure receiving standard medical therapy.
Academia and Clinic
Robert J. Sherertz, E. Wesley Ely, Debi M. Westbrook, Kate S. Gledhill, Stephen A. Streed, Betty Kiger, Lenora Flynn, Stewart Hayes, Sallie Strong, Julia Cruz, David L. Bowton, Todd Hulgan, and Edward F. Haponik Physicians-in-training participated in a course designed to standardize infection control practices. This course proved to be cost-effective and was associated with improved sterile technique and a significantly reduced risk for catheter-related infections.
Updates
Steven M. Albelda, Rainer Wiewrodt, and Jonathan B. Zuckerman This Update examines general concepts in gene therapy, summarizes the results of published clinical trials, and highlights areas of research aimed at overcoming challenges in the field.
Reviews
Wendy Todaro Thanassi and Robert T. Schoen The Lyme disease vaccine, approved by the Food and Drug Administration in 1998, is important because it may reduce the morbidity and financial costs associated with Lyme disease. Through the vaccine's unique mechanism, the vaccine works inside the tick vector itself, preventing humans from becoming infected.
Editorials
Charles M. Clark, Jr. Wei and colleagues' findings, reported in this issue, remind us that a comprehensive exercise program should be an integral part of diabetes care.
Michael A. LaCombe and Frank Davidoff The recently published book On Being a Doctor 2: Voices of Physicians and Patients contains the best of the published submissions to the On Being a Doctor, On Being a Patient, and Ad Libitum sections of Annals.
Letters More on Alternative Medicine
Doctors' Daughter
Standardization of Hemoglobin A1c Values
Homocyst(e)ine and Cardiovascular Disease
Hyperhomocysteinemia in Hypothyroidism
Rapid-Onset Subfulminant Liver Failure Associated with Troglitazone
Factor VIII Antibodies Developing after a Spider Bite
Cooling Methods for Heatstroke Victims
Abolished Vagal Tone Associated with Thyrotoxicosis Triggers Prinzmetal Variant Angina and Paroxysmal Atrial Fibrillation
Cocaine Washout Syndrome
Use of Bromelain for Mild Ulcerative Colitis
Acute Pancreatitis Associated with Celecoxib
Apoptosis in Cardiac Myxoma
Propanolol Administration in a Patient with Thyroid Storm
Ischemic Colitis Associated with Decongestant Use
Parvovirus B19 and Glomerulonephritis in a Healthy Adult
John J. Condemi
Karen A. Wendel and Thomas C. Quinn
David Macpherson
Brigid Kane
Paul T. Kefalides
Paula Tatarunis
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