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Articles 
Andrew S. Levey, Juan P. Bosch, Julia Breyer Lewis, Tom Greene, Nancy Rogers, David Roth for the Modification of Diet in Renal Disease Study Group* The serum creatinine concentration is widely used as an index of renal function, but this measure is affected by factors other than the glomerular filtration rate (GFR). This study examined an equation to predict GFR from serum creatinine concentrations and other factors.
Sapna Syngal, Eugenie H. Coakley, Walter C. Willett, Tim Byers, David F. Williamson, and Graham A. Colditz Weight cycling was highly prevalent in a large cohort of middle-aged women. Independent of attained relative body weight, the risk for cholecystectomy associated with weight cycling was substantial.
Larry W. Moreland, Michael H. Schiff, Scott W. Baumgartner, Elizabeth A. Tindall, Roy M. Fleischmann, Ken J. Bulpitt, Arthur L. Weaver, Edward C. Keystone, Daniel E. Furst, Philip J. Mease, Eric M. Ruderman, David A. Horwitz, Daniel G. Arkfeld, Leslie Garrison, Daniel J. Burge, Consuelo M. Blosch, Mary L.M. Lange, Neil D. McDonnell, and Michael E. Weinblatt Etanercept can safely provide rapid, clinically significant, and sustained benefit in patients with active rheumatoid arthritis.
Kerstin Malmstrom, Guillermo Rodriguez-Gomez, Jeremias Guerra, Cesar Villaran, Andres Piñeiro, Lynn X. Wei, Beth C. Seidenberg, Theodore F. Reiss for the Montelukast/Beclomethasone Study Group* Beclomethasone had a larger mean effect than montelukast, but both drugs provided clinical benefit to patients with chronic asthma. This finding is consistent with the use of these agents as controller medications for chronic asthma.
Ronald D. Chervin, Daniel L. Murman, Beth A. Malow, and Vicken Totten The cost–utility of polysomnography instead of home study or no testing for the diagnosis of the obstructive sleep apnea syndrome compares favorably with that of other procedures for which society judges the added utility per dollar spent to be worthwhile.
Brief Communications
Marius M. Hoeper, Jost Niedermeyer, Frank Hoffmeyer, Peer Flemming, and Helmut Fabel Patients who have had splenectomy may be at increased risk for pulmonary hypertension.
Roy M. Gulick, Vincent McAuliffe, Jeanne Holden-Wiltse, Clyde Crumpacker, Leonard Liebes, Daniel S. Stein, Patricia Meehan, Sheila Hussey, Janet Forcht, Fred T. Valentine for the AIDS Clinical Trials Group 150 and 258 Protocol Teams Hypericin, the active compound in St. John's wort, caused significant phototoxicity and had no antiretroviral activity in HIV-infected patients.
Academia and Clinic
Amy C. Justice, Kenneth E. Covinsky, and Jesse A. Berlin This paper describes an approach for evaluating prognostic systems based on the accuracy and generalizability of the system's predictions.
Medicine and Public Issues
James D. Lewis and David A. Asch Low reimbursement may limit the adoption of screening flexible sigmoidoscopy with or without biopsy in primary care practices.
Editorials
Lewis J. Smith In patients with asthma, the overall response rate to the gold standard treatment, corticosteroids, may be as low as 70%. Clearly, there is a need to identify treatments that are effective when corticosteroids are not. Malmstrom and colleagues' study in this issue contributes to other studies that have increased our understanding of the beneficial effects and safety of leukotriene receptor antagonists.
Allan I. Pack and Indira Gurubhagavatula In this issue, Chervin and colleagues present a cost–utility analysis that evaluates the relative effectiveness of three diagnostic strategies for the obstructive sleep apnea syndrome. This analysis points the way to a more rigorous cost-based approach to assessment of the relative value of different diagnostic strategies.
On Being a Patient
Catharine Dewar
Catharine Dewar
Letters Primaquine Prophylaxis against Malaria
Myocardial Infarction Associated with Buprenorphine
Lipoprotein(a) in Acromegaly
Low Rate of Venous Thromboembolism in Asymptomatic Relatives of Probands with Factor V Leiden Mutation
Oregon's Death with Dignity Act: Ten Months Later
David A. Lacher and Matthew W. Morgan
Mary Graves Johnson
Virginia Gennis
Brigid Kane
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