Plasma Exchange in Multiple Myeloma

  1. Nelson Leung, MD
  1. From Mayo Clinic, Rochester, MN 55905.

    TO THE EDITOR:

    The long-awaited randomized, controlled trial of plasma exchange by Clark and colleagues (1) has finally been published. As the largest trial on the subject, it was supposed to help define the role of plasma exchange in multiple myeloma. However, on closer evaluation of the data, I found more questions than answers.

    First, what disease was actually treated with plasma exchange in this study? Autopsy data from Ivanyi (2) found light-chain deposition disease, amyloidosis, and cast nephropathy in …

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    1. Ann Intern Med March 21, 2006 vol. 144 no. 6 455
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