Table of Contents

October 4, 2005; 143 (7)

Articles

  • Estimated Risks for Developing Obesity in the Framingham Heart Study

    • Ramachandran S. Vasan,
    • Michael J. Pencina,
    • Mark Cobain,
    • Matthew S. Freiberg,
    • and Ralph B. D'Agostino
    Ann Intern Med October 4, 2005 143:473-480

    The authors estimated the short-term, long-term, and lifetime risks of 4117 Framingham participants becoming overweight or obese. People seldom progressed from normal weight to obesity in 4 years. In 4 years, the transition from overweight to obese occurred in 12% of men and 16% to 23% of women, depending on age. The 30-year risk for a body mass index of 35 kg/m2 or greater was 11% to 13%. The risk for a body mass index of 40 kg/m2 or greater was 2.5% to 5%.

  • Evidence-Based Therapies and Mortality in Patients Hospitalized in December with Acute Myocardial Infarction

    • Trip J. Meine,
    • Manesh R. Patel,
    • Venita DePuy,
    • Lesley H. Curtis,
    • Sunil V. Rao,
    • Bernard J. Gersh,
    • Kevin A. Schulman,
    • and James G. Jollis
    Ann Intern Med October 4, 2005 143:481-485

    People have speculated that patients who have an acute myocardial infarction in December have worse outcomes because evidence-based therapies are less available during the holiday season. The authors compared patients hospitalized with acute myocardial infarction in December and in other months. Patients hospitalized in December received evidence-based therapies at the same rate as in other months but had higher 30-day mortality rates (21.7% vs. 20.1%).

  • The Cost-Effectiveness of Screening the U.S. Blood Supply for West Nile Virus

    • Brian Custer,
    • Michael P. Busch,
    • Anthony A. Marfin,
    • and Lyle R. Petersen
    Ann Intern Med October 4, 2005 143:486-492

    The authors assessed the cost-effectiveness of nucleic acid amplification testing of the U.S. blood supply for West Nile virus (WNV). They considered several strategies for testing minipool (pools of 6 to 16 donations) or individual donations. Cost-effectiveness was $483 000 per quality-adjusted life-year for year-long nationwide testing of minipools. Strategies involving individual donation testing were less cost-effective. Testing the U.S. blood supply for WNV is not cost-effective by current criteria.

Academia and Clinic

  • Clinical Decision Making during Public Health Emergencies: Ethical Considerations

    • Bernard Lo and
    • Mitchell H. Katz
    Ann Intern Med October 4, 2005 143:493-498

    In public health emergencies, the needs of a population of affected people may compete with the needs of a physician's patient, which may change the physician's role as advocate for the patient. According to the authors, physicians can advocate for an individual patient by seeking exceptions to policies and by giving care to lessen the adverse consequences of public health measures.

Review

  • Pathogenesis of Gout

    • Hyon K. Choi,
    • David B. Mount,
    • and Anthony M. Reginato
    Ann Intern Med October 4, 2005 143:499-516

    Researchers have recently made advances in defining the pathogenesis of gout, including elucidating its risk factors and tracing the molecular mechanisms of renal urate transport and crystal-induced inflammation. This article reviews recent advances in understanding the pathogenesis of gout.

Clinical Guidelines

  • Screening for Hereditary Hemochromatosis: A Clinical Practice Guideline from the American College of Physicians

    • Amir Qaseem,
    • Mark Aronson,
    • Nick Fitterman,
    • Vincenza Snow,
    • Kevin B. Weiss,
    • Douglas K. Owens,
    • and for the Clinical Efficacy Assessment Subcommittee of the American College of Physicians*
    Ann Intern Med October 4, 2005 143:517-521

    The purpose of this guideline is to teach internists and other primary care physicians to be aware of screening, case-finding, and genetic testing strategies for hereditary hemochromatosis. The target patient population is all persons who may develop hereditary hemochromatosis, including the relatives of individuals who already have the disease.

  • Screening Primary Care Patients for Hereditary Hemochromatosis with Transferrin Saturation and Serum Ferritin Level: Systematic Review for the American College of Physicians

    • Brian Schmitt,
    • Robert M. Golub,
    • and Richard Green
    Ann Intern Med October 4, 2005 143:522-536

    This background review supports the American College of Physicians' clinical practice guideline on screening for hereditary hemochromatosis.

Editorials

  • Meeting Transfusion Safety Expectations

    • James P. AuBuchon
    Ann Intern Med October 4, 2005 143:537-538

    The incredibly rapid adaptation of nucleic acid tests for West Nile virus (WNV), along with declining WNV incidence in many parts of the United States, has allowed blood banks and patients to breathe much easier. However, in this issue, Custer and colleagues provide a careful and circumspect cost-effectiveness analysis of WNV screening in blood banks. Their model shows that from a population perspective, WNV testing is very costly relative to its benefits, which affect relatively few people.

  • The Growing Paradigm of Preventing Disease: Vaccines To Prevent Herpes Zoster and Pertussis in Adults

    • Gregory A. Poland
    Ann Intern Med October 4, 2005 143:539-541

    Two recent studies have shown that vaccines designed to prevent herpes zoster (shingles) and pertussis are safe and effective. These vaccines expand the growing paradigm of active disease prevention in adults. The author discusses vaccination in this context and what clinicians can do to provide the best care to their patients.

Letters

  • Fumbled Handoffs

    • Darius A. Rastegar
    Ann Intern Med October 4, 2005 143:542

  • Fumbled Handoffs

    • Kenneth M. Kessler
    Ann Intern Med October 4, 2005 143:542

  • Fumbled Handoffs

    • Tejal K. Gandhi
    Ann Intern Med October 4, 2005 143:542-543

  • l-Thyroxine plus Liothyronine in Hypothyroidism

    • Jean Eisinger
    Ann Intern Med October 4, 2005 143:543

  • l-Thyroxine plus Liothyronine in Hypothyroidism

    • José I. Botella-Carretero and
    • Héctor F. Escobar-Morreale
    Ann Intern Med October 4, 2005 143:543-544

  • C-Reactive Protein and Risk for Colorectal Cancer

    • Luca Mascitelli and
    • Francesca Pezzetta
    Ann Intern Med October 4, 2005 143:544

  • C-Reactive Protein and Risk for Colorectal Cancer

    • Shumin M. Zhang and
    • Paul M Ridker
    Ann Intern Med October 4, 2005 143:544

  • The Diabetes Prevention Program and the Metabolic Syndrome

    • Priscilla S. Sarinas and
    • Daniel S. Dube
    Ann Intern Med October 4, 2005 143:544-545

  • The Diabetes Prevention Program and the Metabolic Syndrome

    • Frank A. Anania,
    • Samir Parekh,
    • and Aasma Shaukat
    Ann Intern Med October 4, 2005 143:545

  • The Diabetes Prevention Program and the Metabolic Syndrome

    • Trevor J. Orchard,
    • Marinella Temprosa,
    • and Robert Ratner
    Ann Intern Med October 4, 2005 143:545-546

  • Modafinil for the Treatment of Fatigue in Primary Biliary Cirrhosis

    • Marshall M. Kaplan and
    • Peter A.L. Bonis
    Ann Intern Med October 4, 2005 143:546-547

  • Interaction between Simvastatin and l-Thyroxine

    • Eldad Kisch and
    • Hermil S. Segall
    Ann Intern Med October 4, 2005 143:547

  • Correction: Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility

    Ann Intern Med October 4, 2005 143:547

Medical Writings: Book Notes

  • The Drug Trial: Nancy Olivieri and the Science Scandal That Rocked the Hospital for Sick Children

    • Kim A. Carmichael
    Ann Intern Med October 4, 2005 143:548

  • Bioterrorism: A Guide for Hospital Preparedness

    • John R. Middleton
    Ann Intern Med October 4, 2005 143:548

Medical Notices

  • Medical Notices

    Ann Intern Med October 4, 2005 143:0

Summaries for Patients

  • Short- and Long-Term Risks for Middle-Aged Adults Becoming Overweight or Obese

    Ann Intern Med October 4, 2005 143:I-12

  • Care and Outcomes of Patients Hospitalized with Heart Attack in December

    Ann Intern Med October 4, 2005 143:I-21

  • The Cost-Effectiveness of Screening the U.S. Blood Supply for West Nile Virus

    Ann Intern Med October 4, 2005 143:I-44

  • Screening for Hereditary Hemochromatosis: Recommendations from the American College of Physicians

    Ann Intern Med October 4, 2005 143:I-46
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This Issue

October 4, 2005; 143 (7)
  1. Articles
  2. Academia and Clinic
  3. Review
  4. Clinical Guidelines
  5. Editorials
  6. Letters
  7. Medical Writings: Book Notes
  8. Medical Notices
  9. Summaries for Patients

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