Table of Contents

September 20, 2005; 143 (6)

Articles

  • A Comparison of Brand-Name Drug Prices between Canadian-Based Internet Pharmacies and Major U.S. Drug Chain Pharmacies

    • Bradley S. Quon,
    • Rafael Firszt,
    • and Mark J. Eisenberg
    Ann Intern Med September 20, 2005 143:397-403

    The authors compared retail prices at Canadian Internet pharmacies and major U.S. chain pharmacies that provide prices on their Web sites. Of 44 brand-name medications examined, 40 were less expensive in Canada. By purchasing from Canadian Internet pharmacies rather than from U.S. major drug store chains, consumers would save an average of 35%.

  • A Health System Program To Reduce Work Disability Related to Musculoskeletal Disorders

    • Lydia Abásolo,
    • Margarita Blanco,
    • Javier Bachiller,
    • Gloria Candelas,
    • Paz Collado,
    • Cristina Lajas,
    • Marcelino Revenga,
    • Patricia Ricci,
    • Pablo Lázaro,
    • Maria Dolores Aguilar,
    • Emilio Vargas,
    • Benjamín Fernández-Gutiérrez,
    • César Hernández-García,
    • Loreto Carmona,
    • and Juan A. Jover
    Ann Intern Med September 20, 2005 143:404-414

    The authors evaluated the potential cost-effectiveness of a population-based clinical program offered to patients with recent onset of work disability in Madrid, Spain. The intervention and control groups had similar numbers of disability episodes, but patients in the intervention group had shorter episodes, received less long-term disability compensation, and had lower direct and indirect costs.

  • Efficacy and Safety of Second-Generation Antidepressants in the Treatment of Major Depressive Disorder

    • Richard A. Hansen,
    • Gerald Gartlehner,
    • Kathleen N. Lohr,
    • Bradley N. Gaynes,
    • and Timothy S. Carey
    Ann Intern Med September 20, 2005 143:415-426

    The authors systematically evaluated studies of the efficacy, effectiveness, and tolerability of commonly prescribed second-generation antidepressants for major depressive disorder. Second-generation antidepressants probably do not differ substantially, and current evidence is not helpful in deciding which agent is most appropriate for a given patient.

Improving Patient Care

  • Meta-Analysis: Chronic Disease Self-Management Programs for Older Adults

    • Joshua Chodosh,
    • Sally C. Morton,
    • Walter Mojica,
    • Margaret Maglione,
    • Marika J. Suttorp,
    • Lara Hilton,
    • Shannon Rhodes,
    • and Paul Shekelle
    Ann Intern Med September 20, 2005 143:427-438

    The authors examined studies of the effectiveness of self-management programs for osteoarthritis, hypertension, and diabetes mellitus. Self-management programs appear to produce clinically important benefits for patients with hypertension and diabetes, but the evidence is not sufficient to identify the program elements that are most responsible for improved outcomes.

Review

  • Premalignant and In Situ Breast Disease: Biology and Clinical Implications

    • Grazia Arpino,
    • Rodolfo Laucirica,
    • and Richard M. Elledge
    Ann Intern Med September 20, 2005 143:446-457

    This review describes the types of premalignant breast lesions. It describes their likelihood of becoming invasive cancer and the molecular events of progression to invasive cancer. It also outlines the evidence about how to manage these lesions.

Medicine and Public Issues

  • Moving beyond Round Pegs and Square Holes: Restructuring Medicare To Improve Chronic Care

    • Jennifer L. Wolff and
    • Chad Boult
    Ann Intern Med September 20, 2005 143:439-445

    Chronic disease is common in Medicare beneficiaries, yet Medicare's benefit structure and reimbursement mechanisms do not encourage high-quality chronic disease care. This paper describes state-of-the-art innovations in such care, discusses how the Centers for Medicare & Medicaid Services is trying to improve chronic disease care through changes in benefit structure and provider reimbursement, and suggests opportunities to accelerate progress.

Editorials

  • Chronic Disease Care: Rearranging the Deck Chairs

    • David M. Lawrence
    Ann Intern Med September 20, 2005 143:458-459

    The care of patients with chronic disease is one of the most urgent medical challenges facing the United States. Although the articles by Chodosh and colleagues and Wolff and Boult are useful, studies of one intervention divert attention from underlying issues. The bigger picture combines health care providers and their interactions, support staff, care pathways, diagnostic and therapeutic technologies, information and communications infrastructure, clinical decision-making systems, and real-time evaluation and learning loops, all applied over the lifetime of a chronic illness. A silver bullet won't cure what ails us.

  • Influenza A (H5N1): Will It Be the Next Pandemic Influenza? Are We Ready?

    • John G. Bartlett and
    • Frederick G. Hayden
    Ann Intern Med September 20, 2005 143:460-462

    Influenza experts have been predicting a pandemic flu for many years. What they fear most is an epidemic like the Spanish flu of 1918 to 1919—the largest outbreak of fatal infectious disease during the past century. Avian influenza (influenza A [H5N1]) appears to have the potential to cause a worldwide pandemic. So how real is this risk?

On Being a Doctor

  • A Page from My Oncology Fellowship

    • Mansoina Baweja
    Ann Intern Med September 20, 2005 143:463

    Lauren was 26 years old when she received the diagnosis of advanced, aggressive lymphoma. She started chemotherapy at my institution when I was a first-year hematology–oncology fellow. Basically cheerful, she remained upbeat. She had an 8-month-old son, and she was in and out of the hospital all the time. In all those admissions, I never heard her complain about anything. Many days when I was overwhelmed with the fellowship and my 3-year-old, I would think of her and feel lucky.

Letters

  • Cost-Effectiveness of Clopidogrel plus Aspirin versus Aspirin Alone

    • Michael Rothberg
    Ann Intern Med September 20, 2005 143:464

  • Cost-Effectiveness of Clopidogrel plus Aspirin versus Aspirin Alone

    • Peter Eriksson
    Ann Intern Med September 20, 2005 143:464

  • Cost-Effectiveness of Clopidogrel plus Aspirin versus Aspirin Alone

    • Mark D. Schleinitz and
    • Paul A. Heidenreich
    Ann Intern Med September 20, 2005 143:464-465

  • Leukopenia and Thrombocytopenia Caused by Thiazolidinediones

    • Colleen Digman,
    • Andreas K. Klein,
    • and Anastassios G. Pittas
    Ann Intern Med September 20, 2005 143:465-466

  • New Onset of Myelofibrosis in Association with Pulmonary Arterial Hypertension

    • Uday Popat,
    • Adaani Frost,
    • Enli Liu,
    • Romelia May,
    • Remzi Bag,
    • Vishnu Reddy,
    • and Josef T. Prchal
    Ann Intern Med September 20, 2005 143:466-467

  • Improving the Introductions of Manuscripts

    • Matthew P. Smith,
    • Jason S. Haukoos,
    • and Roger J. Lewis
    Ann Intern Med September 20, 2005 143:467-468

  • Correction: Meta-Analysis: Surgical Treatment of Obesity

    Ann Intern Med September 20, 2005 143:468

Current Clinical Issues

  • U.S. Needs More Physicians Soon, but How Many More Is Debatable

    • Jennifer Fisher Wilson
    Ann Intern Med September 20, 2005 143:469-472

Medical Notices

  • Medical Notices

    Ann Intern Med September 20, 2005 143:0

Summaries for Patients

  • Price Comparison for Brand Name Drugs Purchased through the Internet from Canada- and U.S.-based Pharmacies

    Ann Intern Med September 20, 2005 143:I-24

  • An Intervention Program To Decrease the Duration and Cost of Work Disability Related to Musculoskeletal Disorders

    Ann Intern Med September 20, 2005 143:I-30

  • Chronic Disease Self-Management Programs for Older Adults

    Ann Intern Med September 20, 2005 143:I-32
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This Issue

September 20, 2005; 143 (6)
  1. Articles
  2. Improving Patient Care
  3. Review
  4. Medicine and Public Issues
  5. Editorials
  6. On Being a Doctor
  7. Letters
  8. Current Clinical Issues
  9. Medical Notices
  10. Summaries for Patients

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