Meta-Analysis: Pharmacologic Treatment of Obesity

  1. Zhaoping Li, MD, PhD;
  2. Margaret Maglione, MPP;
  3. Wenli Tu, MS;
  4. Walter Mojica, MD;
  5. David Arterburn, MD, MPH;
  6. Lisa R. Shugarman, PhD;
  7. Lara Hilton, BA;
  8. Marika Suttorp, MS;
  9. Vanessa Solomon, MA;
  10. Paul G. Shekelle, MD, PhD; and
  11. Sally C. Morton, PhD
  1. From the Southern California Evidence-Based Practice Center, which includes RAND Health Division, Santa Monica, and the Greater Los Angeles VA Healthcare System, Los Angeles, California; and Department of Veterans Affairs, Cincinnati, Ohio.
    1. Figure 1. HTA = Health Technology Assessment; NHS = National Health Service. *See the companion article by Maggard et al. in this issue. †These 39 articles were randomized, controlled trials and reviews of sibutramine, phentermine, and diethylpropion.
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      Figure 1. HTA = Health Technology Assessment; NHS = National Health Service. *See the companion article by Maggard et al. in this issue. †These 39 articles were randomized, controlled trials and reviews of sibutramine, phentermine, and diethylpropion. Literature flow.
    2. Figure 2. Data are from reference .  = 0.14 (chi-square test); I = 43%.
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      Figure 2. Data are from reference .  = 0.14 (chi-square test); I = 43%. Pooled analysis of weighted mean difference in weight loss with sibutramine versus placebo at 44 to 54 weeks.35P2
    3. Figure 3.  = 0.00 (chi-square test); I = 83%.
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      Figure 3.  = 0.00 (chi-square test); I = 83%. Pooled analysis of mean difference in weight loss with orlistat versus placebo at 12 months.P2
    4. Figure 4. For bupropion,  = 0.00 (chi-square test) and I = 84%. For fluoxetine,  = 0.00 (chi-square test) and I = 85%.
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      Figure 4. For bupropion,  = 0.00 (chi-square test) and I = 84%. For fluoxetine,  = 0.00 (chi-square test) and I = 85%. Pooled analysis of weight loss with bupropion and fluoxetine versus placebo at 6 to 12 months.P2P2
    5. Figure 5.  = 0.00 (chi-square test) and I = 87%.
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      Figure 5.  = 0.00 (chi-square test) and I = 87%. Pooled analysis of weight loss with topiramate versus placebo at 6 months.P2

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      Ann Intern Med published online October 26, 2009

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    1. Ann Intern Med April 5, 2005 vol. 142 no. 7 532-546
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