Table of Contents

April 5, 2005; 142 (7)

Articles

  • The Risk for Myocardial Infarction with Cyclooxygenase-2 Inhibitors: A Population Study of Elderly Adults

    • Linda E. Lévesque,
    • James M. Brophy,
    • and Bin Zhang
    Ann Intern Med April 5, 2005 142:481-489

    This observational cohort study provides evidence that elderly people who currently use rofecoxib have a dose-related increased risk for acute myocardial infarction. Other nonsteroidal anti-inflammatory drugs, including celecoxib, were not associated with increased risk.

  • A Randomized Trial of Diagnostic Strategies after Normal Proximal Vein Ultrasonography for Suspected Deep Venous Thrombosis: d-Dimer Testing Compared with Repeated Ultrasonography

    • Clive Kearon,
    • Jeffrey S. Ginsberg,
    • James Douketis,
    • Mark A. Crowther,
    • Alexander G. Turpie,
    • Shannon M. Bates,
    • Agnes Lee,
    • Patrick Brill-Edwards,
    • Terri Finch,
    • and Michael Gent
    Ann Intern Med April 5, 2005 142:490-496

    This randomized study compared two diagnostic strategies for suspected deep venous thrombosis. The starting point is a normal result on ultrasonography of the proximal leg veins. A strategy based on d-dimer testing followed by no further testing if the results were negative and venography if the results were positive identified substantially more cases than a strategy of repeated ultrasonography in 1 week. The rates of late venous thromboembolism were the same, however.

  • Cystatin C Concentration as a Risk Factor for Heart Failure in Older Adults

    • Mark J. Sarnak,
    • Ronit Katz,
    • Catherine O. Stehman-Breen,
    • Linda F. Fried,
    • Nancy Swords Jenny,
    • Bruce M. Psaty,
    • Anne B. Newman,
    • David Siscovick,
    • Michael G. Shlipak,
    • and and the Cardiovascular Health Study*
    Ann Intern Med April 5, 2005 142:497-505

    Cystatin C, a cysteine proteinase inhibitor produced by all nucleated cells, is a new and promising marker of kidney dysfunction. Its serum concentration is an independent risk factor for onset of heart failure in older adults and provides a better measure of risk than serum creatinine.

  • Brief Communication: Duration of Platelet Dysfunction after a 7-Day Course of Ibuprofen

    • Neil A. Goldenberg,
    • Linda Jacobson,
    • and Marilyn J. Manco-Johnson
    Ann Intern Med April 5, 2005 142:506-509

    This study evaluated platelet function in 11 healthy volunteers for 24 hours following completion of a 7-day course of 600 mg of ibuprofen every 8 hours. Platelet function was normal in all patients by 24 hours. The results suggest that it is safe to continue ibuprofen until 24 hours before surgery.

Review

  • Meta-Analysis: Low-Dose Dopamine Increases Urine Output but Does Not Prevent Renal Dysfunction or Death

    • Jan O. Friedrich,
    • Neill Adhikari,
    • Margaret S. Herridge,
    • and Joseph Beyene
    Ann Intern Med April 5, 2005 142:510-524

    Surveys show that physicians continue to prescribe low-dose dopamine for acute renal dysfunction, even though neither evidence nor editorials and reviews support its use. This meta-analysis found that low-dose dopamine has no benefit for acute renal dysfunction.

Position Papers

  • Ethics Manual: Fifth Edition

    • Lois Snyder,
    • Cathy Leffler,
    • and for the Ethics and Human Rights Committee, American College of Physicians*
    Ann Intern Med April 5, 2005 142:560-582

    The fifth edition of the American College of Physicians' Ethics Manual covers emerging issues in medical ethics and revisits old ones. It reflects on many of the ethical tensions faced by internists and their patients and attempts to shed light on how existing principles extend to emerging concerns. In addition, by reiterating ethical principles that have provided guidance in resolving past ethical problems, the Manual may help physicians avert future problems.

Clinical Guidelines

  • Pharmacologic and Surgical Management of Obesity in Primary Care: A Clinical Practice Guideline from the American College of Physicians

    • Vincenza Snow,
    • Patricia Barry,
    • Nick Fitterman,
    • Amir Qaseem,
    • Kevin Weiss,
    • and for the Clinical Efficacy Assessment Subcommittee of the American College of Physicians*
    Ann Intern Med April 5, 2005 142:525-531

    This guideline provides recommendations for the pharmacologic and surgical treatment of obesity. The target audience is all clinicians caring for patients with a body mass index of 30 kg/m2 or greater.

  • Meta-Analysis: Pharmacologic Treatment of Obesity

    • Zhaoping Li,
    • Margaret Maglione,
    • Wenli Tu,
    • Walter Mojica,
    • David Arterburn,
    • Lisa R. Shugarman,
    • Lara Hilton,
    • Marika Suttorp,
    • Vanessa Solomon,
    • Paul G. Shekelle,
    • and Sally C. Morton
    Ann Intern Med April 5, 2005 142:532-546

    This meta-analysis of studies of pharmacologic treatment of obesity supports the American College of Physicians' clinical guideline in this issue. Sibutramine, orlistat, phentermine, bupropion, and topiramate—and probably fluoxetine and diethylpropion—promote modest weight loss when given along with recommendations for diet.

  • Meta-Analysis: Surgical Treatment of Obesity

    • Melinda A. Maggard,
    • Lisa R. Shugarman,
    • Marika Suttorp,
    • Margaret Maglione,
    • Harvey J. Sugerman,
    • Edward H. Livingston,
    • Ninh T. Nguyen,
    • Zhaoping Li,
    • Walter A. Mojica,
    • Lara Hilton,
    • Shannon Rhodes,
    • Sally C. Morton,
    • and Paul G. Shekelle
    Ann Intern Med April 5, 2005 142:547-559

    This meta-analysis on surgical treatment of obesity supports the American College of Physicians' clinical guideline in this issue. Surgery is more effective than nonsurgical treatment for weight loss and control of some comorbid conditions in patients with a body mass index of 40 kg/m2 or greater. The advantage of surgery for milder forms of obesity is not clear.

Editorials

  • Revisiting the Past Strengthens the Present: An Evidence-Based Medicine Approach for the Diagnosis of Deep Venous Thrombosis

    • Russell D. Hull
    Ann Intern Med April 5, 2005 142:583-585

    The article in this issue by Kearon and colleagues compares two strategies for being sure that patients with suspected deep venous thrombosis are successfully diagnosed and treated. One of them involves contrast venography, a seldom-used test that offers a complete one-visit diagnostic strategy but also a small added risk.

  • Cystatin C, Serum Creatinine, and Estimates of Kidney Function: Searching for Better Measures of Kidney Function and Cardiovascular Risk

    • Adeera Levin
    Ann Intern Med April 5, 2005 142:586-588

    In this issue, Sarnak and colleagues underscore what we know about the association between chronic kidney disease and cardiovascular disease, what we need to know (the mechanisms by which chronic kidney disease affects cardiovascular disease), and what we can do with what we currently know (improve the accuracy of chronic kidney disease measures and use cystatin C as a novel prognostic indicator for heart failure).

Letters

  • Angiotensin-Converting Enzyme Inhibitors in Black Patients

    • Jay S. Kaufman and
    • John M. Flack
    Ann Intern Med April 5, 2005 142:589

  • Angiotensin-Converting Enzyme Inhibitors in Black Patients

    • Lizzy M. Brewster,
    • Gert A. van Montfrans,
    • and Jos Kleijnen
    Ann Intern Med April 5, 2005 142:589-590

  • Computed Tomography versus Endoscopic Ultrasonography for Staging of Pancreatic Cancer

    • William M. Tierney,
    • Michael L. Kochman,
    • and James M. Scheiman
    Ann Intern Med April 5, 2005 142:590

  • Computed Tomography versus Endoscopic Ultrasonography for Staging of Pancreatic Cancer

    • John M. DeWitt,
    • Thomas F. Imperiale,
    • and Stuart Sherman
    Ann Intern Med April 5, 2005 142:590-591

  • The Physiologic Basis of High-Altitude Diseases

    • Buddha Basnyat
    Ann Intern Med April 5, 2005 142:591

  • The Physiologic Basis of High-Altitude Diseases

    • Anil Pandit
    Ann Intern Med April 5, 2005 142:591

  • The Physiologic Basis of High-Altitude Diseases

    • Matiram Pun
    Ann Intern Med April 5, 2005 142:591-592

  • The Physiologic Basis of High-Altitude Diseases

    • John B. West
    Ann Intern Med April 5, 2005 142:592

  • Correction: Plasma Level of a Triggering Receptor Expressed on Myeloid Cells-1

    Ann Intern Med April 5, 2005 142:592

Medical Notices

  • Medical Notices

    Ann Intern Med April 5, 2005 142:0

Summaries for Patients

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This Issue

April 5, 2005; 142 (7)
  1. Articles
  2. Review
  3. Position Papers
  4. Clinical Guidelines
  5. Editorials
  6. Letters
  7. Medical Notices
  8. Summaries for Patients

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