Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

Figure 2. Area of each square is proportional to inverse of study variance in the analysis. Horizontal lines represent 95% CIs. ADCS = Alzheimer's Disease Cooperative Study; AREDS = Age-Related Eye Diseases Study; ATBC = Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group; CHAOS = Cambridge Heart Antioxidant Study; DATATOP = Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism; GISSI-Prevenzione = Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarcto Miocardio Prevenzione; HOPE = Heart Outcomes Prevention Evaluation; MIN.VIT.AOX = The Geriatrie/MINéraux, VITamines, et AntiOXydants Network; MRC/BHF HPS = Medical Research Council/British Heart Foundation Heart Protection Study; PPP = Primary Prevention Project; PPS = Polyp Prevention Study; REACT = Roche European American Cataract Trial; SPACE = Secondary Prevention with Antioxidants of Cardiovascular disease in Endstage renal disease; SU.VI.MAX = SUpplementation en VItamines et Minéraux AntioXydants; VECAT = Vitamin E, Cataracts, and Age-Related Maculopathy; WAVE = Women's Angiographic Vitamin and Estrogen.
Figure 2. Area of each square is proportional to inverse of study variance in the analysis. Horizontal lines represent 95% CIs. ADCS = Alzheimer's Disease Cooperative Study; AREDS = Age-Related Eye Diseases Study; ATBC = Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group; CHAOS = Cambridge Heart Antioxidant Study; DATATOP = Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism; GISSI-Prevenzione = Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarcto Miocardio Prevenzione; HOPE = Heart Outcomes Prevention Evaluation; MIN.VIT.AOX = The Geriatrie/MINéraux, VITamines, et AntiOXydants Network; MRC/BHF HPS = Medical Research Council/British Heart Foundation Heart Protection Study; PPP = Primary Prevention Project; PPS = Polyp Prevention Study; REACT = Roche European American Cataract Trial; SPACE = Secondary Prevention with Antioxidants of Cardiovascular disease in Endstage renal disease; SU.VI.MAX = SUpplementation en VItamines et Minéraux AntioXydants; VECAT = Vitamin E, Cataracts, and Age-Related Maculopathy; WAVE = Women's Angiographic Vitamin and Estrogen. Risk difference in all-cause mortality for randomized, controlled trials of vitamin E supplementation and pooled results for low-dosage (<400 IU/d) and high-dosage (≥400 IU/d) vitamin E trials.

This Article

  1. Published online before print November 10, 2004, Ann Intern Med January 4, 2005 vol. 142 no. 1 37-46
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