Noninvasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease: Implications of Different Meta-Analytic Strategies

  1. John V. Peter, MD; and
  2. John L. Moran, MBBS, FRACP, FANZCA
  1. From Lyell McEwin Health Centre, Elizabeth, South Australia 5112; and The Queen Elizabeth Hospital, Woodville, South Australia 5011.

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    TO THE EDITOR:

    Background: Recent meta-analyses (1-3) have examined the role of noninvasive ventilation in acute exacerbations of chronic obstructive pulmonary disease (COPD).

    Objective: To assess the use of different analytic strategies in interpreting the results of these meta-analyses.

    Methods and Findings: Two issues are important in considering evidence for use of noninvasive ventilation in acute exacerbations of COPD. First, what …

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