Table of Contents

April 6, 2004; 140 (7)

Articles

  • Survival after Initial Diagnosis of Alzheimer Disease

    • Eric B. Larson,
    • Marie-Florence Shadlen,
    • Li Wang,
    • Wayne C. McCormick,
    • James D. Bowen,
    • Linda Teri,
    • and Walter A. Kukull
    Ann Intern Med April 6, 2004 140:501-509

    In community-dwelling elderly persons with Alzheimer disease, survival was shorter than predicted from U.S. population data. Features significantly associated with reduced survival at diagnosis included earlier age at onset, worse cognitive impairment, decreased function, falls, frontal release signs, and abnormal gait.

  • Clinical Spectrum Associated with Hepatocyte Nuclear Factor-1β Mutations

    • Christine Bellanné-Chantelot,
    • Dominique Chauveau,
    • Jean-François Gautier,
    • Danièle Dubois-Laforgue,
    • Séverine Clauin,
    • Sandrine Beaufils,
    • Jean-Marie Wilhelm,
    • Christian Boitard,
    • Laure-Hélène Noël,
    • Gilberto Velho,
    • and José Timsit
    Ann Intern Med April 6, 2004 140:510-517

    Maturity-onset diabetes of the young type 5 encompasses a wide clinical spectrum of defects in organogenesis, which are related to specific mutations in hepatocyte nuclear factor-1β. Nonobese patients with diabetes and slowly progressive nondiabetic nephropathy should be tested for mutations of hepatocyte nuclear factor-1β.

  • Short-Term Treatment with Proton-Pump Inhibitors as a Test for Gastroesophageal Reflux Disease: A Meta-Analysis of Diagnostic Test Characteristics

    • Mattijs E. Numans,
    • Joseph Lau,
    • Niek J. de Wit,
    • and Peter A. Bonis
    Ann Intern Med April 6, 2004 140:518-527

    Successful short-term treatment with a proton-pump inhibitor in patients suspected of having gastroesophageal reflux disease (GERD) does not change the probability of GERD enough to establish the diagnosis. When treatment is not successful, the probability of GERD decreases only slightly.

  • Predicting Adherence to Colonoscopy or Flexible Sigmoidoscopy on the Basis of Physician Appointment–Keeping Behavior

    • Barbara J. Turner,
    • Mark Weiner,
    • Chuya Yang,
    • and Thomas TenHave
    Ann Intern Med April 6, 2004 140:528-532

    No-show rates for physician appointments predicted attendance at colorectal endoscopic studies. High no-show rates for appointments with physicians may signify patients who need special reminders about appointments for endoscopy.

Brief Communications

  • Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use

    • Sebastian J. Padayatty,
    • He Sun,
    • Yaohui Wang,
    • Hugh D. Riordan,
    • Stephen M. Hewitt,
    • Arie Katz,
    • Robert A. Wesley,
    • and Mark Levine
    Ann Intern Med April 6, 2004 140:533-537

    The plasma concentration of vitamin C is regulated within narrow limits, and oral vitamin C has little effect on plasma levels. Intravenous administration of vitamin C results in high plasma and urine concentrations. This finding may explain discrepancies between past studies of the antitumor effects of vitamin C. Future studies of the role of vitamin C in cancer treatment should examine the intravenous route of administration.

NIH Conferences

  • West Nile Virus: Pathogenesis and Therapeutic Options

    • Juan Gea-Banacloche,
    • Richard T. Johnson,
    • Anto Bagic,
    • John A. Butman,
    • Patrick R. Murray,
    • and Amy Guillet Agrawal
    Ann Intern Med April 6, 2004 140:545-553

    With more than 9000 cases and 200 deaths in the United States in 2003, West Nile virus has become the most common cause of viral encephalitis in several states. This paper discusses the pathogenesis of West Nile virus, available diagnostic tests, and potential treatment.

Clinical Guidelines

  • Exercise Tolerance Testing To Screen for Coronary Heart Disease: A Systematic Review for the Technical Support for the U.S. Preventive Services Task Force

    • Angela Fowler-Brown,
    • Michael Pignone,
    • Mark Pletcher,
    • Jeffrey A. Tice,
    • Sonya F. Sutton,
    • and Kathleen N. Lohr
    Ann Intern Med April 6, 2004 140:W-9-W-24

  • Screening and Behavioral Counseling Interventions in Primary Care To Reduce Alcohol Misuse: Recommendation Statement

    • U.S. Preventive Services Task Force*
    Ann Intern Med April 6, 2004 140:554-556

    The U.S. Preventive Services Task Force (USPSTF) recommends screening and behavioral counseling interventions to reduce alcohol misuse by adults, including pregnant women, in primary care settings. The USPSTF concludes that the evidence is insufficient to recommend for or against interventions to prevent or reduce alcohol misuse by adolescents in primary care settings.

  • Behavioral Counseling Interventions in Primary Care To Reduce Risky/Harmful Alcohol Use by Adults: A Summary of the Evidence for the U.S. Preventive Services Task Force

    • Evelyn P. Whitlock,
    • Michael R. Polen,
    • Carla A. Green,
    • Tracy Orleans,
    • and Jonathan Klein
    Ann Intern Med April 6, 2004 140:557-568

    Behavioral counseling interventions are effective and could be part of a public health approach to reducing harmful use of alcohol by adult primary care patients. Future research should test strategies to facilitate adoption of these practices into routine health care.

  • Screening for Coronary Heart Disease: Recommendation Statement

    • U.S. Preventive Services Task Force*
    Ann Intern Med April 6, 2004 140:569-572

    Among other recommendations, the U.S. Preventive Services Task Force recommends against routine screening with resting electrocardiography, exercise treadmill test, or electron-beam computerized tomography for coronary calcium for either the presence of severe coronary artery stenosis or predicting coronary heart disease events in adults at low risk for coronary heart disease events.

Editorial

  • Dementia, Prognosis, and the Needs of Patients and Caregivers

    • Kenneth E. Covinsky and
    • Kristine Yaffe
    Ann Intern Med April 6, 2004 140:573-574

    According to a study in this issue, Alzheimer disease halves life expectancy at the time of diagnosis. This study can help patients, caregivers, and clinicians to set priorities within their respective roles. Thinking of dementia as a progressive, chronic disease may help clinicians to focus on palliative care planning and to assess their patients' preferences for care at the end of life.

On Being a Doctor

  • Shades

    • Bonnie Salomon
    Ann Intern Med April 6, 2004 140:575-576

    Mr. B. most likely saw me not as a physician caring for him but as a shade of white, a voice of institutional racism—the enemy.

Letters

  • Effects of Losartan in Hypertension without Vascular Disease

    • Franz H. Messerli
    Ann Intern Med April 6, 2004 140:W-29

  • New Case of Acute Hepatitis Following the Consumption of Shou Wu Pian, a Chinese Herbal Product Derived from Polygonum multiflorum

    • Gabriela Mazzanti,
    • Lucia Battinelli,
    • Claudia Daniele,
    • Claudio Maria Mastroianni,
    • Miriam Lichtner,
    • Simona Coletta,
    • and Sergio Costantini
    Ann Intern Med April 6, 2004 140:W-30

  • Treatment of Early Lyme Disease

    • Raphael B. Stricker,
    • Andrea Gaito,
    • Nick S. Harris,
    • and Joseph J. Burrascano
    Ann Intern Med April 6, 2004 140:577

  • Treatment of Early Lyme Disease

    • Gary P. Wormser,
    • John Nowakowski,
    • and Robert B. Nadelman
    Ann Intern Med April 6, 2004 140:577-578

  • HIV Survival Benefit Associated with Earlier Antiviral Therapy

    • Amanda Mocroft,
    • Andrew N. Phillips,
    • and Jens D. Lundgren
    Ann Intern Med April 6, 2004 140:578-579

  • HIV Survival Benefit Associated with Earlier Antiviral Therapy

    • Frank J. Palella, Jr.,
    • Joan S. Chmiel,
    • and Scott D. Holmberg
    Ann Intern Med April 6, 2004 140:579

  • Itraconazole versus Fluconazole for Antifungal Prophylaxis

    • Meinolf Karthaus,
    • Oliver A. Cornely,
    • and Andrew J. Ullmann
    Ann Intern Med April 6, 2004 140:579-580

  • Itraconazole versus Fluconazole for Antifungal Prophylaxis

    • John H. Powers and
    • Karen M. Higgins
    Ann Intern Med April 6, 2004 140:580

  • Itraconazole versus Fluconazole for Antifungal Prophylaxis

    • Sherif B. Mossad
    Ann Intern Med April 6, 2004 140:580-581

  • Itraconazole versus Fluconazole for Antifungal Prophylaxis

    • Drew J. Winston,
    • Richard T. Maziarz,
    • and Pranatharthi H. Chandrasekar
    Ann Intern Med April 6, 2004 140:581-582

  • Suboptimal Monitoring and Dosing of Unfractionated Heparin

    • Kevin K. Chung,
    • Jeanne K. Tofferi,
    • and William T. Browne
    Ann Intern Med April 6, 2004 140:582

  • Suboptimal Monitoring and Dosing of Unfractionated Heparin

    • Robert Raschke,
    • Jack Hirsh,
    • and James R. Guidry
    Ann Intern Med April 6, 2004 140:582-583

  • Eponyms and the Diagnosis of Aortic Regurgitation

    • George Dermksian
    Ann Intern Med April 6, 2004 140:583

  • Eponyms and the Diagnosis of Aortic Regurgitation

    • Lakshmi V. Atkuri and
    • Abu R. Vasudevan
    Ann Intern Med April 6, 2004 140:583

  • Eponyms and the Diagnosis of Aortic Regurgitation

    • Ajit N. Babu,
    • Sharon M. Carpenter Fryer,
    • and Steven M. Kymes
    Ann Intern Med April 6, 2004 140:583-584

  • Renal Insufficiency and Heart Failure Therapy

    • Aaron Spital
    Ann Intern Med April 6, 2004 140:584

  • Renal Insufficiency and Heart Failure Therapy

    • Michael G. Shlipak
    Ann Intern Med April 6, 2004 140:584

  • Mixing Politics and Zen

    • W. Harry Horner
    Ann Intern Med April 6, 2004 140:584-585

  • Mixing Politics and Zen

    • James L. Reinertsen
    Ann Intern Med April 6, 2004 140:585

  • The Cost of Medicine

    • Barry Kisloff
    Ann Intern Med April 6, 2004 140:585

  • Judging a Confession

    • Sheila Feit
    Ann Intern Med April 6, 2004 140:585-586

  • Judging a Confession

    • H. James Merchant
    Ann Intern Med April 6, 2004 140:586

  • Montelukast-Induced Hepatitis

    • Marc F. Goldstein,
    • James Anoia,
    • and Martin Black
    Ann Intern Med April 6, 2004 140:586-587

Medical Writings: Book Notes

  • Mortal Secrets: Truth and Lies in the Age of AIDS

    • Marla J. Gold
    Ann Intern Med April 6, 2004 140:588

  • Alzheimer's Disease: A Physician's Guide to Practical Management

    • Calvin H. Hirsch
    Ann Intern Med April 6, 2004 140:588

Ad Libitum

Book Listings

  • Book Listings

    Ann Intern Med April 6, 2004 140:0

Medical Notices

  • Medical Notices

    Ann Intern Med April 6, 2004 140:0

Summaries for Patients

  • Early Symptoms Help Predict Survival Time in Patients with Alzheimer's Disease

    Ann Intern Med April 6, 2004 140:I-26

  • Maturity Onset Diabetes of the Young 5

    Ann Intern Med April 6, 2004 140:I-42

  • Does Symptom Response Diagnose Gastroesophageal Reflux Disease?

    Ann Intern Med April 6, 2004 140:I-51

  • Why Some People Do Not Show Up for Planned Colorectal Cancer Screening

    Ann Intern Med April 6, 2004 140:I-55

  • How Vitamin C Is Administered Affects How Much Reaches the Bloodstream and May Affect the Results of Studies of Its Potential Effect on Cancer

    Ann Intern Med April 6, 2004 140:I-61

  • Screening and Counseling To Reduce Alcohol Misuse: Recommendations from the United States Preventive Services Task Force

    Ann Intern Med April 6, 2004 140:I-64

  • Screening for Coronary Heart Disease: Recommendations from the U.S. Preventive Services Task Force

    Ann Intern Med April 6, 2004 140:I-95

Updates from the Annual Session

  • Update in Women's Health

    • Molly Carnes and
    • Jane E. Mahoney
    Ann Intern Med April 6, 2004 140:538-544

    For internists, women's health generally encompasses nonobstetric reproductive health, sex and gender differences in diseases that occur in both men and women, and conditions that occur predominantly or uniquely in women. This Update discusses reports on genitourinary conditions, hormone therapy, cardiovascular disease, and breast cancer.

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This Issue

April 6, 2004; 140 (7)
  1. Articles
  2. Brief Communications
  3. NIH Conferences
  4. Clinical Guidelines
  5. Editorial
  6. On Being a Doctor
  7. Letters
  8. Medical Writings: Book Notes
  9. Ad Libitum
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients
  13. Updates from the Annual Session

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