Table of Contents

February 3, 2004; 140 (3)

Articles

  • A Prospective Study of Aspirin Use and the Risk for Colorectal Adenoma

    • Andrew T. Chan,
    • Edward L. Giovannucci,
    • Eva S. Schernhammer,
    • Graham A. Colditz,
    • David J. Hunter,
    • Walter C. Willett,
    • and Charles S. Fuchs
    Ann Intern Med February 3, 2004 140:157-166

    Taking aspirin regularly is associated with a reduced risk for colorectal adenoma. The greatest effect occurred at substantially higher doses than those recommended for prevention of cardiovascular disease. Before recommending aspirin chemoprevention for all adults, we must understand the risks and benefits of routine aspirin use at these higher doses.

  • The Metabolic Syndrome and Chronic Kidney Disease in U.S. Adults

    • Jing Chen,
    • Paul Muntner,
    • L. Lee Hamm,
    • Daniel W. Jones,
    • Vecihi Batuman,
    • Vivian Fonseca,
    • Paul K. Whelton,
    • and Jiang He
    Ann Intern Med February 3, 2004 140:167-174

    The metabolic syndrome is defined as 3 or more of the following: hypertension, hyperglycemia, low high-density lipoprotein cholesterol levels, high triglyceride level, and abdominal obesity. The greater the number of these factors, the greater a person's risk for microalbuminuria and chronic kidney disease.

  • Low-Molecular-Weight Heparin Compared with Intravenous Unfractionated Heparin for Treatment of Pulmonary Embolism: A Meta-Analysis of Randomized, Controlled Trials

    • Daniel J. Quinlan,
    • Andrew McQuillan,
    • and John W. Eikelboom
    Ann Intern Med February 3, 2004 140:175-183

    Fixed-dose low-molecular-weight heparin appears to be as effective and safe as dose-adjusted intravenous unfractionated heparin for the initial treatment of pulmonary embolism. This conclusion does not necessarily apply to patients with massive pulmonary embolism because the trials excluded them.

Brief Communications

  • Changes in the Use of Postmenopausal Hormone Therapy after the Publication of Clinical Trial Results

    • Jennifer S. Haas,
    • Celia P. Kaplan,
    • Eric P. Gerstenberger,
    • and Karla Kerlikowske
    Ann Intern Med February 3, 2004 140:184-188

    According to this study, more public media attention is associated with greater adoption of clinical research results. The release of the Women's Health Initiative trial results was associated with a greater decline in postmenopausal hormone therapy use than occurred after publication of the Heart and Estrogen/progestin Replacement Study results, which received much less attention from newspapers and television.

Academia and Clinic

  • Sources of Variation and Bias in Studies of Diagnostic Accuracy: A Systematic Review

    • Penny Whiting,
    • Anne W.S. Rutjes,
    • Johannes B. Reitsma,
    • Afina S. Glas,
    • Patrick M.M. Bossuyt,
    • and Jos Kleijnen
    Ann Intern Med February 3, 2004 140:189-202

    Many factors in measuring the sensitivity and specificity of diagnostic tests can lead to biased estimates or variation between studies. Empirical evidence about the size and effect of these issues is limited.

Review

  • Effect of Alcohol Consumption on Diabetes Mellitus: A Systematic Review

    • Andrea A. Howard,
    • Julia H. Arnsten,
    • and Marc N. Gourevitch
    Ann Intern Med February 3, 2004 140:211-219

    Moderate alcohol consumption is associated with a decreased risk for developing diabetes mellitus and a decreased risk for heart disease in persons with diabetes. The long-term effects of alcohol consumption on glycemic control and noncardiac complications in persons with diabetes are poorly understood.

Perspectives

  • “Special Scrutiny”: A Targeted Form of Research Protocol Review

    • Carol Levine,
    • Ruth Faden,
    • Christine Grady,
    • Dale Hammerschmidt,
    • Lisa Eckenwiler,
    • Jeremy Sugarman,
    • and on behalf of the Consortium to Examine Clinical Research Ethics
    Ann Intern Med February 3, 2004 140:220-223

    Existing laws and regulations protect research participants. However, some research protocols need additional “special scrutiny” because they create unusual ethical problems. The aim of special scrutiny is full protection for all research participants.

Editorials

  • Aspirin Prevention of Colorectal Cancer: More or Less?

    • Robert S. Sandler
    Ann Intern Med February 3, 2004 140:224-225

    The concept of cancer chemoprevention is tantalizing. If we had a cheap, nontoxic pill that could reduce the risk for cancer, we might reduce the need for surgery or toxic chemotherapy. In this issue, Chan and colleagues provide additional evidence that we may already have such an agent for colorectal cancer. Its identity? Aspirin.

  • The Media Matter: A Call for Straightforward Medical Reporting

    • Lisa M. Schwartz and
    • Steven Woloshin
    Ann Intern Med February 3, 2004 140:226-228

    Over half of U.S. adults report that they follow health news closely. Thus, the press is well positioned to educate the public about health and health risks and what medicine can (and cannot) do. Researchers and medical journals have an obligation to help the media do their job responsibly.

On Being a Doctor

  • Possession

    • Cecil G. Helman
    Ann Intern Med February 3, 2004 140:229-230

    They sit across the desk from me, the young couple, both tense and distracted. I am very new to family practice, and John is almost exactly the same age as I am. We are the same height and shape, and we have the same style of moustache. We are even dressed in a similar way. But there's a pinched, sallow look about his face, as if the mirror I am peering into is blurred and slightly dusty.

Letters

  • Eponyms and the Diagnosis of Aortic Regurgitation

    • Allen B. Weisse
    Ann Intern Med February 3, 2004 140:W-5

  • Adverse Events following Discharge from the Hospital

    • Donald C. Rifas
    Ann Intern Med February 3, 2004 140:231

  • Adverse Events following Discharge from the Hospital

    • Bruce Leff and
    • Chad Boult
    Ann Intern Med February 3, 2004 140:231

  • Adverse Events following Discharge from the Hospital

    • Matthew M. Medlock,
    • Louis R. Cantilena, Jr.,
    • and Michael A. Riel
    Ann Intern Med February 3, 2004 140:231-232

  • Adverse Events following Discharge from the Hospital

    • Rodney A. Hayward and
    • Timothy P. Hofer
    Ann Intern Med February 3, 2004 140:232

  • Adverse Events following Discharge from the Hospital

    • Alan J. Forster and
    • David W. Bates
    Ann Intern Med February 3, 2004 140:232-233

  • Reversible Tricuspid Stenosis Secondary to Massive Ascites in Hepatic Cirrhosis

    • J. M. García-Pinilla,
    • J. J. Gómez-Doblas,
    • I. Rodríguez-Bailón,
    • R. Alcantara,
    • M. F. Jiménez-Navarro,
    • and E. De Teresa
    Ann Intern Med February 3, 2004 140:233-234

  • Mass Media–Induced Availability Bias in the Clinical Suspicion of West Nile Fever

    • Mayer Brezis,
    • Daphna Halpern-Reichert,
    • and Mitchell J. Schwaber
    Ann Intern Med February 3, 2004 140:234-235

Medical Writings: Book Notes

Ad Libitum

Book Listings

  • Book Listings

    Ann Intern Med February 3, 2004 140:0

Medical Notices

  • Medical Notices

    Ann Intern Med February 3, 2004 140:0

Summaries for Patients

  • Relationships between Aspirin Dose and Colorectal Adenomas

    Ann Intern Med February 3, 2004 140:I-24

  • Association of the Metabolic Syndrome and Chronic Kidney Disease in U.S. Adults

    Ann Intern Med February 3, 2004 140:I-39

  • Treatment of Pulmonary Embolism

    Ann Intern Med February 3, 2004 140:I-43

  • Changes in the Use of Postmenopausal Hormone Replacement Therapy after the Publication of Study Results

    Ann Intern Med February 3, 2004 140:I-50

  • Effects of Drinking on the Risk for Diabetes and Its Complications

    Ann Intern Med February 3, 2004 140:I-72

Updates from the Annual Session

  • Update in Cardiology

    • Elliot Rapaport
    Ann Intern Med February 3, 2004 140:203-210

    This Update focuses on heart failure, acute coronary syndromes, hypertension, and lowering of low-density lipoprotein cholesterol levels. The newer clinical trials in these fields are changing approaches to cardiac care.

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This Issue

February 3, 2004; 140 (3)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Review
  5. Perspectives
  6. Editorials
  7. On Being a Doctor
  8. Letters
  9. Medical Writings: Book Notes
  10. Ad Libitum
  11. Book Listings
  12. Medical Notices
  13. Summaries for Patients
  14. Updates from the Annual Session

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