Table of Contents

October 21, 2003; 139 (8)

Articles

  • Topical Treatment of Pressure Ulcers with Nerve Growth Factor: A Randomized Clinical Trial

    • Francesco Landi,
    • Luigi Aloe,
    • Andrea Russo,
    • Matteo Cesari,
    • Graziano Onder,
    • Stefano Bonini,
    • Pier Ugo Carbonin,
    • and Roberto Bernabei
    Ann Intern Med October 21, 2003 139:635-641

    Topical application of nerve growth factor may be an effective therapy for patients with severe pressure ulcers.

  • Serum Insulin-like Growth Factor I and Risk for Heart Failure in Elderly Individuals without a Previous Myocardial Infarction: The Framingham Heart Study

    • Ramachandran S. Vasan,
    • Lisa M. Sullivan,
    • Ralph B. D'Agostino,
    • Ronenn Roubenoff,
    • Tamara Harris,
    • Douglas B. Sawyer,
    • Daniel Levy,
    • and Peter W.F. Wilson
    Ann Intern Med October 21, 2003 139:642-648

    In this prospective, community-based study, serum insulin-like growth factor I level was inversely related to the risk for congestive heart failure in elderly people without a previous myocardial infarction.

  • Association of Hospital Procedure Volume and Outcomes in Patients with Colon Cancer at High Risk for Recurrence

    • Jeffrey A. Meyerhardt,
    • Paul J. Catalano,
    • Deborah Schrag,
    • John Z. Ayanian,
    • Daniel G. Haller,
    • Robert J. Mayer,
    • John S. Macdonald,
    • Al B. Benson III,
    • and Charles S. Fuchs
    Ann Intern Med October 21, 2003 139:649-657

    According to prospectively recorded data from a large clinical trial, patients whose colon cancer was resected at low-volume hospitals had a higher risk for long-term mortality; however, this increased mortality was not attributable to differences in colon cancer recurrence.

  • The Effect of Clustering of Outcomes on the Association of Procedure Volume and Surgical Outcomes

    • Katherine S. Panageas,
    • Deborah Schrag,
    • Elyn Riedel,
    • Peter B. Bach,
    • and Colin B. Begg
    Ann Intern Med October 21, 2003 139:658-665

    The presence of clustering represents variations in outcomes among providers with similar volumes. Thus, investigators of volume–outcome studies should characterize the degree of clustering of outcomes because doing so may provide insight into variations in quality of care.

Reviews

  • Effects of Statins on Nonlipid Serum Markers Associated with Cardiovascular Disease: A Systematic Review

    • Ethan M. Balk,
    • Joseph Lau,
    • Leonidas C. Goudas,
    • Harmon S. Jordan,
    • Bruce Kupelnick,
    • Linda U. Kim,
    • and Richard H. Karas
    Ann Intern Med October 21, 2003 139:670-682

    Among nonlipid serum markers, only C-reactive protein levels are significantly affected by statins. These findings suggest that statin-mediated anti-inflammatory effects may contribute to the ability of these drugs to reduce risk for cardiovascular disease. Overall, however, available data are insufficient to support recommendations for using nonlipid serum markers in decisions about statin therapy for individual patients.

  • Delayed Drug Hypersensitivity Reactions

    • Werner J. Pichler
    Ann Intern Med October 21, 2003 139:683-693

    Immune reactions to small molecular compounds, such as drugs, can cause many diseases involving the skin, liver, kidney, and lungs. This review examines how T cells recognize drugs; the cross-reactivity of drug-specific T cells; innate immunity and drug hypersensitivity; and drug-induced maculopapular, bullous, and pustular exanthema.

Editorials

  • The Promise of Topical Growth Factors in Healing Pressure Ulcers

    • David R. Thomas
    Ann Intern Med October 21, 2003 139:694-695

    In this issue, Landi and colleagues report on the topical treatment of pressure ulcers with nerve growth factor. Although the authors have shown that topical nerve growth factor was clearly superior to vehicle control in their study, future studies must be done to demonstrate whether this treatment is better than other conventional therapies.

  • Does Practice Really Make Perfect?

    • Christine Laine and
    • Harold C. Sox
    Ann Intern Med October 21, 2003 139:696-698

    Given the high stakes of surgical treatment, where should patients go when they need surgery? Common sense and a growing literature suggest that they should seek surgeons and hospitals that frequently perform the needed procedure. After all, practice makes perfect, doesn't it? The studies by Meyerhardt and Panageas and their colleagues reported in this issue suggest that the answer to this question is considerably more complicated than it appears.

On Being a Doctor

  • A Sudden Change in Vision

    • Grace Emerson Terrell
    Ann Intern Med October 21, 2003 139:699-700

    My first emotion was irritation. It was Friday afternoon around 5 o'clock, and it had been a particularly busy week. Then one of the nurses brought me one more patient message to deal with before I got out. “Mrs. Jones called to say that she has had blurred vision ever since she had that echo test this morning.” I smirked. Suddenly echocardiograms were mysteriously causing visual difficulties.

Letters

  • A Critical Overview of Homeopathy

    • Flávio Dantas,
    • Peter Fisher,
    • and Hagen Rampes
    Ann Intern Med October 21, 2003 139:W-73

  • A Critical Overview of Homeopathy

    • Renan M.V.R. Almeida
    Ann Intern Med October 21, 2003 139:W-74

  • A Critical Overview of Homeopathy

    • Giovanni Federspil,
    • Fabio Presotto,
    • and Roberto Vettor
    Ann Intern Med October 21, 2003 139:W-75

  • A Critical Overview of Homeopathy

    • Wayne Jonas
    Ann Intern Med October 21, 2003 139:W-76

  • Notice of Retraction

    • Harold C. Sox
    Ann Intern Med October 21, 2003 139:702

  • Hospitalist Care

    • William Rifkin,
    • Brad Flansbaum,
    • and Steven Walerstein
    Ann Intern Med October 21, 2003 139:702

  • Hospitalist Care

    • Jonathan P. Whitney
    Ann Intern Med October 21, 2003 139:702-703

  • Hospitalist Care

    • Tariq Shafi
    Ann Intern Med October 21, 2003 139:703

  • Hospitalist Care

    • Jerome S. Tannenbaum
    Ann Intern Med October 21, 2003 139:703-704

  • CPR for Patients Labeled DNR

    • Muriel Gillick
    Ann Intern Med October 21, 2003 139:704

  • CPR for Patients Labeled DNR

    • Jack P. Freer
    Ann Intern Med October 21, 2003 139:704

  • CPR for Patients Labeled DNR

    • Susan B. LeGrand
    Ann Intern Med October 21, 2003 139:704-705

  • CPR for Patients Labeled DNR

    • Bernard M. Karnath
    Ann Intern Med October 21, 2003 139:705

  • CPR for Patients Labeled DNR

    • Niteesh K. Choudhry,
    • Sujit Choudhry,
    • and Peter A. Singer
    Ann Intern Med October 21, 2003 139:705-706

  • The Hungry Bone Syndrome after Medical Treatment of Thyrotoxicosis

    • Marvin Grieff
    Ann Intern Med October 21, 2003 139:706-707

  • Unexpected Risks during Administration of Conscious Sedation: Previously Undiagnosed Obstructive Sleep Apnea

    • Vinay K. Sharma,
    • William Galli,
    • Alan Haber,
    • Mark R. Pressman,
    • Robert Stevenson,
    • Thomas J. Meyer,
    • Donald D. Peterson,
    • John S. Zachariah,
    • Giancarlo Mercogliano,
    • and Lee Greenspon
    Ann Intern Med October 21, 2003 139:707-708

  • HFE Gene Mutations in Chile

    • Nelson Wohllk,
    • Rodrigo Zapata,
    • Mónica Acuña,
    • Humberto Reyes,
    • Alex Navarro,
    • Iván Roa,
    • and Juan Carlos Roa
    Ann Intern Med October 21, 2003 139:708-709

Medical Writings: Book Notes

Current Clinical Issues

  • Should Doctors Prescribe Alcohol to Adults?

    • Jennifer Fisher Wilson
    Ann Intern Med October 21, 2003 139:711-714

Ad Libitum

Book Listings

  • Book Listings

    Ann Intern Med October 21, 2003 139:0

Medical Notices

  • Medical Notices

    Ann Intern Med October 21, 2003 139:0

Summaries for Patients

  • Nerve Growth Factor Improves Healing of Pressure Ulcers of the Foot

    Ann Intern Med October 21, 2003 139:I-10

  • Insulin-like Growth Factor I Levels and Heart Failure Risk in Older People

    Ann Intern Med October 21, 2003 139:I-22

  • Relationships between the Amount of Colon Cancer Surgery a Hospital Performs and Patient Outcomes

    Ann Intern Med October 21, 2003 139:I-28

  • Choice of Statistical Analysis Can Change the Results of Studies of the Relationship between Hospital and Surgeon Volume and Outcomes of Cancer Surgery

    Ann Intern Med October 21, 2003 139:I-44

  • Delayed Drug Hypersensitivity

    Ann Intern Med October 21, 2003 139:I-46

Updates from the Annual Session

  • Update in Oncology

    • Steven H. Stein
    Ann Intern Med October 21, 2003 139:666-669

    This Update discusses 3 important topics in oncology: screening (especially in the field of proteomics), prevention (including preventive measures for human papillomavirus), and therapeutics (including the use of imatinib for treating chronic myelogenous leukemia).

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This Issue

October 21, 2003; 139 (8)
  1. Articles
  2. Reviews
  3. Editorials
  4. On Being a Doctor
  5. Letters
  6. Medical Writings: Book Notes
  7. Current Clinical Issues
  8. Ad Libitum
  9. Book Listings
  10. Medical Notices
  11. Summaries for Patients
  12. Updates from the Annual Session

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