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The Impact of Methadone Induction on Cardiac Conduction in Opiate Users
- Bridget A. Martell, MD;
- Julia H. Arnsten, MD, MPH;
- Beevash Ray, BS; and
- Marc N. Gourevitch, MD, MPH
- Albert Einstein College of Medicine; Bronx, NY 10467 (Martell, Arnsten) Tufts University School of Medicine; Boston, MA 02111 (Ray) Albert Einstein College of Medicine; Bronx, NY 10467 (Gourevitch) Grant Support: Dr. Arnsten was supported in part by a Robert Wood Johnson Generalist Physician Faculty Award. Mr. Ray was supported in part by the New York State Department of Health. The Division of Substance Abuse at Albert Einstein College of Medicine is funded in part by contract C-002464 from the New York State Office of Alcoholism and Substance Abuse Services.
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TO THE EDITOR:
Background: Opiate agonist therapy, specifically levacetylmethadol and high doses of methadone (>300 mg/d), has been associated with QT interval prolongation and torsade de pointes in two recent reports (1, 2). However, no prospective studies have examined the impact of methadone induction on the QT interval. We …
