Table of Contents

July 1, 2003; 139 (1)

Articles

  • Eczematous Skin Disease and Recall of Past Diagnoses: Implications for Smallpox Vaccination

    • Allison L. Naleway,
    • Edward A. Belongia,
    • Robert T. Greenlee,
    • Burney A. Kieke, Jr,
    • Robert T. Chen,
    • and David K. Shay
    Ann Intern Med July 1, 2003 139:1-7

    Relying only on a self-reported history of eczematous skin disease will miss a substantial proportion of individuals who should not receive smallpox vaccine in a preexposure vaccination campaign.

  • Should Immunoglobulin Therapy Be Used in Allogeneic Stem-Cell Transplantation?: A Randomized, Double-Blind, Dose Effect, Placebo-Controlled, Multicenter Trial

    • Catherine Cordonnier,
    • Sylvie Chevret,
    • Marc Legrand,
    • Homa Rafi,
    • Nathalie Dhédin,
    • Blandine Lehmann,
    • François Bassompierre,
    • Eliane Gluckman,
    • and for the GREFIG Study Group*
    Ann Intern Med July 1, 2003 139:8-18

    This clinical trial showed that prophylactic immunoglobulin is not effective in patients undergoing allogeneic hematopoietic stem-cell transplantation.

  • Extended Oral Anticoagulant Therapy after a First Episode of Pulmonary Embolism

    • Giancarlo Agnelli,
    • Paolo Prandoni,
    • Cecilia Becattini,
    • Mauro Silingardi,
    • Maria Rita Taliani,
    • Maddalena Miccio,
    • Davide Imberti,
    • Renzo Poggio,
    • Walter Ageno,
    • Enrico Pogliani,
    • Fernando Porro,
    • Pietro Zonzin,
    • and for the Warfarin Optimal Duration Italian Trial Investigators*
    Ann Intern Med July 1, 2003 139:19-25

    Patients with pulmonary embolism have a substantial risk for recurrence after stopping oral anticoagulation, regardless of the length of treatment. Physicians should try to identify patients who may benefit from indefinite oral anticoagulation because of their high risk for recurrent venous thromboembolism.

Brief Communications

  • Slower Progression of HIV-1 Infection in Persons with GB Virus C Co-Infection Correlates with an Intact T-Helper 1 Cytokine Profile

    • Giuseppe Nunnari,
    • Luciano Nigro,
    • Filippo Palermo,
    • Massimo Attanasio,
    • Annemarie Berger,
    • Hans W. Doerr,
    • Roger J. Pomerantz,
    • and Bruno Cacopardo
    Ann Intern Med July 1, 2003 139:26-30

    GB virus C may interfere with progression of HIV-1 infection by maintaining an intact T-helper 1 cytokine profile.

Improving Patient Care

  • Computer Physician Order Entry: Benefits, Costs, and Issues

    • Gilad J. Kuperman and
    • Richard F. Gibson
    Ann Intern Med July 1, 2003 139:31-39

    The authors examine the potential benefits and costs of computer physician order entry. They also describe issues to consider before implementation of this type of order entry system.

Academia and Clinic

  • The Rise of Litigation in Human Subjects Research

    • Michelle M. Mello,
    • David M. Studdert,
    • and Troyen A. Brennan
    Ann Intern Med July 1, 2003 139:40-45

    While litigation may serve a valuable compensation function for injured participants in human subjects research, it will also profoundly affect institutional review procedures. More mechanistic ethical review, a likely outcome, will not further the interests of human subjects or scientific progress.

Review

  • Test Characteristics of α-Fetoprotein for Detecting Hepatocellular Carcinoma in Patients with Hepatitis C: A Systematic Review and Critical Analysis

    • Samir Gupta,
    • Stephen Bent,
    • and Jeffrey Kohlwes
    Ann Intern Med July 1, 2003 139:46-50

    According to the “best-case” estimates of α-fetoprotein sensitivity and specificity, this test is not effective for detecting hepatocellular carcinoma in hepatitis C virus–infected patients.

Clinical Guidelines

  • Routine Vitamin Supplementation To Prevent Cancer and Cardiovascular Disease: Recommendations and Rationale

    • U.S. Preventive Services Task Force*
    Ann Intern Med July 1, 2003 139:51-55

    According to the U.S. Preventive Services Task Force, the evidence is insufficient to recommend for or against the use of supplements of vitamins A, C, or E; multivitamins with folic acid; or antioxidant combinations to prevent cancer or cardiovascular disease. The Task Force recommends against the use of beta-carotene supplements, either alone or in combination, for preventing cancer or cardiovascular disease.

  • Routine Vitamin Supplementation To Prevent Cardiovascular Disease: A Summary of the Evidence for the U.S. Preventive Services Task Force

    • Cynthia D. Morris and
    • Susan Carson
    Ann Intern Med July 1, 2003 139:56-70

    This systematic review evaluates the evidence that routine vitamin supplementation reduces the risk for cancer and cardiovascular disease.

Editorial

  • Minimizing Risk in Clinical Research

    • Daniel D. Federman
    Ann Intern Med July 1, 2003 139:71-72

    The paper by Mello and colleagues in this issue describes the growth of litigation about protection of participants in research trials, and a letter by Humphreys and associates reports on the costs of institutional review boards. Reconciling the pursuit of new knowledge with minimizing risk to patients and preserving their freedom to sue may prove impossible. In the event of an impasse, society should construct a procedure to compensate research subjects who come to harm.

On Being a Doctor

  • The Aftermath of a Fall

    • Keiki Hinami
    Ann Intern Med July 1, 2003 139:73

    My grandfather, like many, endures the indignity of falling apart. I am powerless and cannot prevent him from falling further. I can only prevent him from falling alone.

  • The Cost of Medicine

    • Shyam K. Bhat
    Ann Intern Med July 1, 2003 139:74-75

    It feels routine now, this mundane ordering of expensive tests with no questions asked about cost. No more do I feel the sense of wonder and amazement that suffused me when I first started working as a physician in the United States. But today, as I order the scan and look into the eyes of this 92-year-old lady with a dying body that all these thousands of dollars will not save, I think back to the boy.

Letters

  • Routine Tandem Transplantation for Patients with Myeloma

    • Jayesh Mehta
    Ann Intern Med July 1, 2003 139:W-54

  • Routine Tandem Transplantation for Patients with Myeloma

    • Kevin Imrie and
    • Ralph M. Meyer
    Ann Intern Med July 1, 2003 139:W-55

  • Bent (Head-Down) Posture and Aberrant Internal Carotid Artery in the Mouth: A New Risk Factor for Stroke?

    • Koichi Tsunoda,
    • Jo Aikawa,
    • Ryusuke Murakami,
    • Yuki Sakai,
    • and Yayoi Suzuki Kikkawa
    Ann Intern Med July 1, 2003 139:W-56

  • Improved Outcomes in a Voluntary Hospitalist Model

    • David Neely
    Ann Intern Med July 1, 2003 139:76

  • Improved Outcomes in a Voluntary Hospitalist Model

    • Andrew D. Auerbach,
    • Robert M. Wachter,
    • and Lee Goldman
    Ann Intern Med July 1, 2003 139:76

  • The Who, What, When, Where, Whom, and How of Hospitalist Care

    • Gordon D. Schiff
    Ann Intern Med July 1, 2003 139:76-77

  • The Cost of Institutional Review Board Procedures in Multicenter Observational Research

    • Keith Humphreys,
    • Jodie Trafton,
    • and Todd H. Wagner
    Ann Intern Med July 1, 2003 139:77

  • Developing and Implementing a Program of Grand Rounds for Internists That Is Free of Commercial Bias

    • Brian J. McMahon,
    • Richard Neubauer,
    • Burton Janis,
    • Steven Tucker,
    • and Mark Agnew
    Ann Intern Med July 1, 2003 139:77-78

  • A New Cutaneous Sign of Mercury Poisoning

    • Paul I. Dantzig
    Ann Intern Med July 1, 2003 139:78-80

Book Listings

Medical Notices

Summaries for Patients

  • Recall of Skin Diseases That Disqualify People from Preexposure Smallpox Vaccination

    Ann Intern Med July 1, 2003 139:I-32

  • Immunoglobulin in Patients with Stem-Cell Transplants

    Ann Intern Med July 1, 2003 139:I-45

  • How Long Should Blood Thinners Be Given to Patients Who Have Had a Pulmonary Embolism?

    Ann Intern Med July 1, 2003 139:I-51

  • Hepatitis G Virus Co-Infection Slows Progression from HIV Infection to AIDS: The Potential Role of Cytokines

    Ann Intern Med July 1, 2003 139:I-65

  • Taking Vitamin Supplements To Prevent Cardiovascular Disease and Cancer: Recommendations from the U.S. Preventive Services Task Force

    Ann Intern Med July 1, 2003 139:I-76
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This Issue

July 1, 2003; 139 (1)
  1. Articles
  2. Brief Communications
  3. Improving Patient Care
  4. Academia and Clinic
  5. Review
  6. Clinical Guidelines
  7. Editorial
  8. On Being a Doctor
  9. Letters
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients

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