Table of Contents

October 1, 2002; 137 (7)

Articles

  • Association of Renal Insufficiency with Treatment and Outcomes after Myocardial Infarction in Elderly Patients

    • Michael G. Shlipak,
    • Paul A. Heidenreich,
    • Haruko Noguchi,
    • Glenn M. Chertow,
    • Warren S. Browner,
    • and Mark B. McClellan
    Ann Intern Med October 1, 2002 137:555-562

    Renal insufficiency was an independent risk factor for death in elderly patients after myocardial infarction. Targeted interventions may be needed to improve treatment for this high-risk population.

  • Acute Myocardial Infarction and Renal Dysfunction: A High-Risk Combination

    • R. Scott Wright,
    • Guy S. Reeder,
    • Charles A. Herzog,
    • Robert C. Albright,
    • Brent A. Williams,
    • David L. Dvorak,
    • Wayne L. Miller,
    • Joseph G. Murphy,
    • Stephen L. Kopecky,
    • and Allan S. Jaffe
    Ann Intern Med October 1, 2002 137:563-570

    Patients with renal failure are at increased risk for death after acute myocardial infarction and receive less aggressive treatment compared with patients who have normal renal function.

  • Prevalence of bcl-2 Rearrangement in Patients with Hepatitis C Virus–Related Mixed Cryoglobulinemia with or without B-Cell Lymphomas

    • Anna Linda Zignego,
    • Clodoveo Ferri,
    • Francesca Giannelli,
    • Carlo Giannini,
    • Patrizio Caini,
    • Monica Monti,
    • Maria Eugenia Marrocchi,
    • Elena Di Pietro,
    • Giorgio La Villa,
    • Giacomo Laffi,
    • and Paolo Gentilini
    Ann Intern Med October 1, 2002 137:571-580

    Patients with chronic hepatitis C and mixed cryoglobulinemia had increased frequency of bcl-2 rearrangement. The frequency was greatest in patients with type II mixed cryoglobulinemia. The high ratio of Bcl-2 to Bax in patients with bcl-2 rearrangement and the disappearance of the rearrangement with antiviral therapy suggest that the translocation is associated with the antiapoptotic function of Bcl-2 and that hepatitis C is linked to inhibition of B-cell apoptosis.

Brief Communications

  • Statin-Associated Myopathy with Normal Creatine Kinase Levels

    • Paul S. Phillips,
    • Richard H. Haas,
    • Sergei Bannykh,
    • Stephanie Hathaway,
    • Nancy L. Gray,
    • Bruce J. Kimura,
    • Georgirene D. Vladutiu,
    • John D.F. England,
    • and the Scripps Mercy Clinical Research Center*
    Ann Intern Med October 1, 2002 137:581-585

    Some patients who develop muscle symptoms while receiving statin therapy have demonstrable weakness and histopathologic findings of myopathy despite normal serum creatine kinase levels. These findings resolve after discontinuation of statin therapy and recur with resumption of therapy.

Academia and Clinic

  • Diagnostic Evaluation of Low Back Pain with Emphasis on Imaging

    • Jeffrey G. Jarvik and
    • Richard A. Deyo
    Ann Intern Med October 1, 2002 137:586-597

    The authors review evidence on the diagnostic accuracy of clinical information and imaging for patients with low back pain in primary care settings.

  • Spectrum Bias or Spectrum Effect? Subgroup Variation in Diagnostic Test Evaluation

    • Stephanie A. Mulherin and
    • William C. Miller
    Ann Intern Med October 1, 2002 137:598-602

    Spectrum bias is a term commonly used to describe the heterogeneity that occurs when diagnostic test performance varies across patient subgroups and a study of that test's performance does not adequately represent all subgroups. This paper proposes the use of the term spectrum effect rather than spectrum bias, and it outlines strategies for using stratified sensitivity and specificity estimates, likelihood ratios, and receiver-operating characteristic curves.

Review

  • The Genetics of Colorectal Cancer

    • Paula M. Calvert and
    • Harold Frucht
    Ann Intern Med October 1, 2002 137:603-612

    Understanding of the epidemiology and molecular genetics of colon cancer is rapidly advancing. With these advances come opportunities for clinically applicable genetic tests. These tests are not perfect and are still prone to false-positive and false-negative results. Thus, the clinical understanding of colon cancer remains the basis for management decisions, with genetic testing having a potentially important supporting role.

Perspectives

  • In Memoriam: J. Russell Elkinton, MD, MACP, FRCP(L); 1910–2002; Editor, Annals of Internal Medicine, 1960–1971

    • Edward J. Huth
    Ann Intern Med October 1, 2002 137:613-614

    Joseph Russell Elkinton, the fourth editor of Annals of Internal Medicine, died on 6 April 2002. He was a diligent, valuable servant of the American College of Physicians–American Society of Internal Medicine and merits a clear place in its history.

Editorials

  • Cardiac Mortality in Chronic Kidney Disease: A Clearer Perspective

    • Raymond R. Townsend
    Ann Intern Med October 1, 2002 137:615-616

    In this issue, Shlipak and Wright and colleagues address the role of impaired kidney function as a risk factor for myocardial infarction. Their findings suggest that clinicians underuse available treatments in patients presenting with acute myocardial infarction and impaired kidney function.

  • Can Statins Cause Chronic Low-Grade Myopathy?

    • Scott M. Grundy
    Ann Intern Med October 1, 2002 137:617-618

    Phillips and colleagues' report in this issue on low-grade myopathy associated with statin use in a few patients highlights the need for further study on the actions of statins on muscle metabolism and structure.

Letters

  • Sequelae and Serologic Outcome in Persons with Hepatitis B Virus Infection

    • Francesca Cainelli and
    • Sandro Vento
    Ann Intern Med October 1, 2002 137:619

  • Sequelae and Serologic Outcome in Persons with Hepatitis B Virus Infection

    • Brian J. McMahon and
    • Lisa Bulkow
    Ann Intern Med October 1, 2002 137:619

  • Risk Index for Postoperative Pneumonia

    • Avery Tung and
    • Jerome M. Klafta
    Ann Intern Med October 1, 2002 137:620

  • Risk Index for Postoperative Pneumonia

    • Ahsan M. Arozullah and
    • Jennifer Daley
    Ann Intern Med October 1, 2002 137:620

  • Extended Out-of-Hospital Low-Molecular-Weight Heparin for Prophylaxis against Deep Venous Thrombosis

    • Naoko Murashige and
    • Roslyn F. Schneider
    Ann Intern Med October 1, 2002 137:620-621

  • Extended Out-of-Hospital Low-Molecular-Weight Heparin for Prophylaxis against Deep Venous Thrombosis

    • Russell D. Hull,
    • Graham F. Pineo,
    • and Andrew F. Mah
    Ann Intern Med October 1, 2002 137:621

  • Quality Indicators for Management of Osteoporosis

    • Douglas C. Bauer and
    • Eric Orwoll
    Ann Intern Med October 1, 2002 137:621-622

  • Automated External Defibrillators

    • Daniel Stryer and
    • William Lawrence
    Ann Intern Med October 1, 2002 137:622

  • Aspirin for the Primary Prevention of Cardiovascular Events

    • George E. McLaughlin
    Ann Intern Med October 1, 2002 137:622-623

  • Caring for Patients at the End of Life

    • Richard Wetzel
    Ann Intern Med October 1, 2002 137:623

  • The Other Résumé

    • David P. Steensma
    Ann Intern Med October 1, 2002 137:623

  • It's Only 50 Cents

    • Nancy R. Angoff
    Ann Intern Med October 1, 2002 137:623

  • Rapid Development of Massive Tendon Xanthomas following Highly Active Antiretroviral Therapy

    • Nathalie Leung,
    • Robert A. Hegele,
    • and Gary F. Lewis
    Ann Intern Med October 1, 2002 137:624

  • Pneumonitis Associated with Nonsteroidal Antiandrogens: Presumptive Evidence of a Class Effect

    • Charles L. Bennett,
    • Dennis W. Raisch,
    • and Oliver Sartor
    Ann Intern Med October 1, 2002 137:625

  • Infliximab-Induced Systemic Lupus Erythematosus

    • Yousaf Ali and
    • Samir Shah
    Ann Intern Med October 1, 2002 137:625-626

  • Bioterrorism and Physicians

    • Andrew W. Artenstein,
    • Marguerite A. Neill,
    • and Steven M. Opal
    Ann Intern Med October 1, 2002 137:626

  • Correction: Articles on Diagnostic Tests

    Ann Intern Med October 1, 2002 137:626

Medical Writings

  • Empathy and the Literary Imagination

    • Lawrence J. Schneiderman
    Ann Intern Med October 1, 2002 137:627-629

    What good is empathy? The closer we get to the feelings of our patients, goes the argument, the better we can understand them and the more likely we will be able to diagnose and treat correctly. This is what novels, stories, and other works of art are supposed to help us with. As a physician and writer I both believe and doubt this.

Medical Writings: Book Notes

  • People in Crisis: Clinical and Public Health Perspectives

    • Jeffrey M. Levine
    Ann Intern Med October 1, 2002 137:630

  • Systematic Reviews in Health Care

    • Lawrence Loo
    Ann Intern Med October 1, 2002 137:630

Book Listings

Medical Notices

Summaries for Patients

  • Kidney Disease and Heart Attacks

    Ann Intern Med October 1, 2002 137:I-12

  • The Influence of Kidney Disease on Outcomes of Patients with Heart Attack

    Ann Intern Med October 1, 2002 137:I-22

  • Effects of Hepatitis C Virus Infection on Genetic Material and on Manifestations of a Related Blood Disease

    Ann Intern Med October 1, 2002 137:I-32

  • Muscle Abnormalities in Four Patients Taking Statins To Treat Unfavorable Cholesterol Levels

    Ann Intern Med October 1, 2002 137:I-45

  • The Genetics of Colorectal Cancer

    Ann Intern Med October 1, 2002 137:I-48
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This Issue

October 1, 2002; 137 (7)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Review
  5. Perspectives
  6. Editorials
  7. Letters
  8. Medical Writings
  9. Medical Writings: Book Notes
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients

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