Screening for Prostate Cancer: An Update of the Evidence for the U.S. Preventive Services Task Force

  1. Russell Harris, MD, MPH; and
  2. Kathleen N. Lohr, PhD
  1. From University of North Carolina at Chapel Hill, Chapel Hill, and Research Triangle Institute, Research Triangle Park, North Carolina.
    1. Figure. The number of cancer cases detected would be smaller after repeated annual screening. * For men in their 50s, = 50; for men in their 70s, = 270. † For men in their 50s, = 150; for men in their 70s, = 400. ‡ For men in their 50s, = 17; for men in their 70s, = 90. § For men in their 50s, = 30; for men in their 70s, = 100. ‖For men in their 50s, = 12; for men in their 70s, = 63. ¶ For men in their 50s, = 21; for men in their 70s, = 70. In all footnotes, numbers are approximate.
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      Figure. The number of cancer cases detected would be smaller after repeated annual screening. * For men in their 50s, = 50; for men in their 70s, = 270. † For men in their 50s, = 150; for men in their 70s, = 400. ‡ For men in their 50s, = 17; for men in their 70s, = 90. § For men in their 50s, = 30; for men in their 70s, = 100. ‖For men in their 50s, = 12; for men in their 70s, = 63. ¶ For men in their 50s, = 21; for men in their 70s, = 70. In all footnotes, numbers are approximate. Estimated yield of screening with prostate-specific antigen (PSA) testing or with PSA testing and digital rectal examination (DRE).nnnnnnnnnnnn
    2. Appendix (Figure 1). Arrows represent steps in the chain of logic connecting screening with reduced morbidity or mortality from prostate cancer. KQ = key question.
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      Appendix (Figure 1). Arrows represent steps in the chain of logic connecting screening with reduced morbidity or mortality from prostate cancer. KQ = key question. Analytic framework for screening for prostate cancer.
    3. Appendix (Figure 2). Direct evidence of screening efficacy. Ecologic studies of screening efficacy. RCT = randomized, controlled trial.
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      Appendix (Figure 2). Direct evidence of screening efficacy. Ecologic studies of screening efficacy. RCT = randomized, controlled trial. Selection of articles based on key question 1.Top.Bottom.
    4. Appendix (Figure 3). Arrows represent steps in the chain of logic connecting screening with reduced morbidity or mortality from prostate cancer.
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      Appendix (Figure 3). Arrows represent steps in the chain of logic connecting screening with reduced morbidity or mortality from prostate cancer. Selection of articles based on key question 2.
    5. Appendix (Figure 4). Key questions 3 through 6 address health outcomes of treatment; key question 7 addresses harms of treatment. RCT = randomized, controlled trial.
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      Appendix (Figure 4). Key questions 3 through 6 address health outcomes of treatment; key question 7 addresses harms of treatment. RCT = randomized, controlled trial. Selection of articles based on key questions 3 through 6 (top) and top question 7 (bottom).
    6. Appendix 5. Key question 8 addresses costs and cost-effectiveness of screening, and key question 9 deals with the harms of screening.
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      Appendix 5. Key question 8 addresses costs and cost-effectiveness of screening, and key question 9 deals with the harms of screening. Selection of articles based on key questions 8 (top) and 9 (bottom).

    Summary for Patients

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