Chemoprevention of Breast Cancer: A Summary of the Evidence for the U.S. Preventive Services Task Force

  1. Linda S. Kinsinger, MD, MPH;
  2. Russell Harris, MD, MPH;
  3. Steven H. Woolf, MD, MPH;
  4. Harold C. Sox, MD; and
  5. Kathleen N. Lohr, PhD
  1. From Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Virginia Commonwealth University, Fairfax, Virginia; American College of Physicians-American Society of Internal Medicine, Philadelphia, Pennsylvania; and Research Triangle Institute, Research Triangle Park, North Carolina.
    1. Figure. Harms include endometrial cancer, stroke, and pulmonary embolism combined. Adapted from reference .
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      Figure. Harms include endometrial cancer, stroke, and pulmonary embolism combined. Adapted from reference . Benefits and harms of chemoprevention with tamoxifen per 10 000 women in three age groups.49
    2. Appendix (Figure 1). KQ = key question. KQ 1: Do chemopreventive agents reduce mortality from breast cancer? KQ 2: Do chemopreventive agents reduce the incidence of breast cancer? KQ 3: Do chemopreventive agents have other beneficial effects? KQ 4: Do chemopreventive agents increase the risk for adverse effects? KQ 5: What are the costs associated with chemoprevention of breast cancer?
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      Appendix (Figure 1). KQ = key question. KQ 1: Do chemopreventive agents reduce mortality from breast cancer? KQ 2: Do chemopreventive agents reduce the incidence of breast cancer? KQ 3: Do chemopreventive agents have other beneficial effects? KQ 4: Do chemopreventive agents increase the risk for adverse effects? KQ 5: What are the costs associated with chemoprevention of breast cancer? Analytical framework.
    3. Appendix (Figure 2). RCTs = randomized, controlled trials.
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      Appendix (Figure 2). RCTs = randomized, controlled trials. Article selection.

    Summary for Patients

    • Summaries for Patients:Using Medication To Prevent Breast Cancer: Recommendations from the United States Preventive Services Task Force Ann Intern Med July 2, 2002 137:I-62
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    1. Ann Intern Med July 2, 2002 vol. 137 no. 1 59-69
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