Postmenopausal Estrogen Replacement and Risk for Venous Thromboembolism

  1. Jill Miller, MD;
  2. Benjamin K.S. Chan, MS; and
  3. Heidi D. Nelson, MD, MPH
  1. From Veterans Affairs Medical Center and Oregon Health & Science University, Portland, Oregon.
    1. Figure 1. Odds ratios for thromboembolic events were higher in the first or second year than in subsequent years in all six studies reporting results by year of use.
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        Figure 1. Odds ratios for thromboembolic events were higher in the first or second year than in subsequent years in all six studies reporting results by year of use. Risk for venous thromboembolism by year of estrogen use.
      • Figure 2. The pooled estimate of venous thromboembolism risk for all 12 studies meeting eligibility criteria was 2.14 (95% credible interval, 1.64 to 2.81). Numbers above the lines ending in arrows indicate the outer limits of the confidence intervals. PEPI = Postmenopausal Estrogen/Progestin Interventions trial.
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          Figure 2. The pooled estimate of venous thromboembolism risk for all 12 studies meeting eligibility criteria was 2.14 (95% credible interval, 1.64 to 2.81). Numbers above the lines ending in arrows indicate the outer limits of the confidence intervals. PEPI = Postmenopausal Estrogen/Progestin Interventions trial. Meta-analysis of estrogen studies.
        • Appendix Figure.
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            Appendix Figure. Flowchart diagram of search and selection of articles.

          Summaries for Patients

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