Table of Contents

February 19, 2002; 136 (4)

Articles

  • Surveillance for Second Primary Colorectal Cancer after Adjuvant Chemotherapy: An Analysis of Intergroup 0089

    • Robert J. Green,
    • Joshua P. Metlay,
    • Kathleen Propert,
    • Paul J. Catalano,
    • John S. Macdonald,
    • Robert J. Mayer,
    • and Daniel G. Haller
    Ann Intern Med February 19, 2002 136:261-269

    The incidence of second primary colorectal cancer after treatment for localized colon cancer remains high despite intensive surveillance strategies.

  • Change in Lung Function and Morbidity from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes: A Longitudinal Study of the General Population

    • Morten Dahl,
    • Anne Tybjærg-Hansen,
    • Peter Lange,
    • Jørgen Vestbo,
    • and Børge G. Nordestgaard
    Ann Intern Med February 19, 2002 136:270-279

    A deteriorating effect of severe α1-antitrypsin deficiency (ZZ genotype) on lung function is well known, whereas the role of intermediate deficiency (MZ genotype) remains uncertain. This study found that MZ heterozygotes had a slightly greater rate of decrease in FEV1 and were modestly over-represented among persons with airway obstruction and chronic obstructive pulmonary disease (COPD). In the population at large, MZ heterozygosity may account for a fraction of COPD cases—on the order of 2%, similar to the percentage of persons with COPD who have the severe but rare ZZ genotype.

  • The Stool Antigen Test for Detection of Helicobacter pylori after Eradication Therapy

    • Dino Vaira,
    • Nimish Vakil,
    • Marcello Menegatti,
    • Ben van't Hoff,
    • Chiara Ricci,
    • Luigi Gatta,
    • Giovanni Gasbarrini,
    • Mario Quina,
    • Jose M. Pajares Garcia,
    • Arie van der Ende,
    • Rene van der Hulst,
    • Marcello Anti,
    • Cristina Duarte,
    • Javier P. Gisbert,
    • Mario Miglioli,
    • and Guido Tytgat
    Ann Intern Med February 19, 2002 136:280-287

    A positive result on the stool antigen test 7 days after completion of therapy identifies patients in whom eradication of Helicobacter pylori was unsuccessful.

Brief Communications

  • Surprisingly Small Effect of Antiviral Treatment in Patients with Hepatitis C

    • Yngve Falck-Ytter,
    • Hemangi Kale,
    • Kevin D. Mullen,
    • Steedman A. Sarbah,
    • Lucian Sorescu,
    • and Arthur J. McCullough
    Ann Intern Med February 19, 2002 136:288-292

    Most patients with hepatitis C virus infection are not candidates for interferon-based therapies; alternative interventions should be sought for these patients.

Review

  • A Current Perspective of Suicide and Attempted Suicide

    • J. John Mann
    Ann Intern Med February 19, 2002 136:302-311

    Suicide is generally a complication of a psychiatric disorder, but it requires additional risk factors because most psychiatric patients never attempt suicide. This review includes a hypothesized stress–diathesis model, which has implications for detection of high-risk patients and treatment interventions, and discusses promising treatment approaches.

Medicine and Public Issues

  • Legal, Financial, and Public Health Consequences of HIV Contamination of Blood and Blood Products in the 1980s and 1990s

    • Peter D. Weinberg,
    • Jennie Hounshell,
    • Laurence A. Sherman,
    • John Godwin,
    • Shirin Ali,
    • Cecilia Tomori,
    • and Charles L. Bennett
    Ann Intern Med February 19, 2002 136:312-319

    This paper summarizes the current status of concerns about the safety of the blood supply in developed countries, where viral transmission from contaminated blood or blood products is extremely rare, and in developing countries, where up to 10% of HIV infections result from transfusion of blood or blood products.

NIH Conferences

  • Future Directions in the Study and Management of Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

    • Deborah P. Merke,
    • Stefan R. Bornstein,
    • Nilo A. Avila,
    • and George P. Chrousos
    Ann Intern Med February 19, 2002 136:320-334

    In the past 50 years, since the discovery of cortisone therapy as an effective treatment for congenital adrenal hyperplasia, many advances have been made in the study and management of 21-hydroxylase deficiency. The discovery of the 21-hydroxylase gene was followed by the discovery of the 21-hydroxylase–deficient mouse, which has provided a useful model for testing new treatments. As our knowledge of this disease expands, new therapies are being developed and tested in both humans and animals.

Editorial

  • Second Primary Colorectal Cancer: The Consequence of Management Failure at Several Potential Levels

    • Paul J. Limburg and
    • David A. Ahlquist
    Ann Intern Med February 19, 2002 136:335-337

    Although the study by Green and colleagues in this issue chronicles a disturbingly high rate of second primary colorectal cancer in patients undergoing surveillance in an adjuvant chemotherapy trial, the junctures at which corrective measures are most needed cannot be precisely determined. For now, adherence to the existing consensus guidelines for postoperative surveillance seems warranted until convincing evidence supports alternative strategies.

Letters

  • Physicians and Capital Punishment

    • Sharon F. Attaway-Kurrle
    Ann Intern Med February 19, 2002 136:W1

  • Pharmacist Scope of Practice

    • Jake Nichols
    Ann Intern Med February 19, 2002 136:W2

  • Influenza: Prospects for Control

    • Joseph J. Mazza and
    • Steven H. Yale
    Ann Intern Med February 19, 2002 136:338

  • Influenza: Prospects for Control

    • Robert B. Couch
    Ann Intern Med February 19, 2002 136:338-339

  • Quinine-Induced Blindness Reversed by an Increase in α1-Acid Glycoprotein Level

    • Giovanni Di Perri,
    • Benedetta Allegranzi,
    • and Stefano Bonora
    Ann Intern Med February 19, 2002 136:339

Medical Writings: Book Notes

  • Physicians' Cancer Chemotherapy Drug Manual 2001

    • Ellen F. Manzullo and
    • Roger W. Anderson
    Ann Intern Med February 19, 2002 136:340

  • Writing, Speaking, and Communication Skills for Health Professionals

    • Howard Schubiner and
    • Susan Eggly
    Ann Intern Med February 19, 2002 136:340

Book Listings

Medical Notices

Summaries for Patients

  • Second Colorectal Cancer in Patients Who Had First Colon Cancer Treated with Surgery and Chemotherapy

    Ann Intern Med February 19, 2002 136:I29

  • Lung Function and Death from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes

    Ann Intern Med February 19, 2002 136:I35

  • Detection of Persistent Helicobacter pylori Infection

    Ann Intern Med February 19, 2002 136:I36

  • Who Gets Antiviral Treatment for Hepatitis C?

    Ann Intern Med February 19, 2002 136:I48

Updates from the Annual Session

  • Update in Psychiatry

    • Robert K. Schneider and
    • James L. Levenson
    Ann Intern Med February 19, 2002 136:293-301

    This Update is the first Update in Psychiatry presented at an Annual Session of the American College of Physicians–American Society of Internal Medicine. The authors cover the following topics: mood disorders, anxiety disorders, geropsychiatry, and new therapeutics.

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This Issue

February 19, 2002; 136 (4)
  1. Articles
  2. Brief Communications
  3. Review
  4. Medicine and Public Issues
  5. NIH Conferences
  6. Editorial
  7. Letters
  8. Medical Writings: Book Notes
  9. Book Listings
  10. Medical Notices
  11. Summaries for Patients
  12. Updates from the Annual Session

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