Aspirin for the Primary Prevention of Cardiovascular Events: A Summary of the Evidence for the U.S. Preventive Services Task
Force

Appendix (Figure 1). CHD = coronary heart disease; CVD = cardiovascular disease; KQ = key question. KQ 1: Does aspirin chemoprevention
in patients without known cardiovascular disease reduce the risk for myocardial infarction, stroke, and death? KQ 2: Does
aspirin chemoprevention increase major gastrointestinal bleeding, hemorrhagic strokes, or both? KQ 3: What is the balance
of benefits and harms for aspirin therapy in patients with different levels of cardiovascular risk?
Analytic framework: aspirin to prevent cardiovascular events.
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Ann Intern Med
January 15, 2002
vol. 136
no. 2
161-172