Table of Contents

July 17, 2001; 135 (2)

Articles

  • Angiotensin-Converting Enzyme Inhibitors and Progression of Nondiabetic Renal Disease: A Meta-Analysis of Patient-Level Data

    • Tazeen H. Jafar,
    • Christopher H. Schmid,
    • Marcia Landa,
    • Ioannis Giatras,
    • Robert Toto,
    • Giuseppe Remuzzi,
    • Giuseppe Maschio,
    • Barry M. Brenner,
    • Annelise Kamper,
    • Pietro Zucchelli,
    • Gavin Becker,
    • Andres Himmelmann,
    • Kym Bannister,
    • Paul Landais,
    • Shahnaz Shahinfar,
    • Paul E. de Jong,
    • Dick de Zeeuw,
    • Joseph Lau,
    • Andrew S. Levey,
    • and the ACE Inhibition in Progressive Renal Disease Study Group*
    Ann Intern Med July 17, 2001 135:73-87

    Antihypertensive regimens that include angiotensin-converting enzyme (ACE) inhibitors are more effective than regimens without these drugs in slowing the progression of nondiabetic renal disease. The beneficial effect of ACE inhibitors is mediated by factors in addition to decreasing blood pressure and urinary protein excretion and is greater in patients with proteinuria. Angiotensin-converting enzyme inhibitors are indicated for treatment of nondiabetic patients with chronic renal disease and proteinuria and, possibly, those without proteinuria.

  • Performance of Helical Computed Tomography in Unselected Outpatients with Suspected Pulmonary Embolism

    • Arnaud Perrier,
    • Nigel Howarth,
    • Dominique Didier,
    • Pierre Loubeyre,
    • Pierre-François Unger,
    • Philippe de Moerloose,
    • Daniel Slosman,
    • Alain Junod,
    • and Henri Bounameaux
    Ann Intern Med July 17, 2001 135:88-97

    Helical computed tomography should not be used alone for suspected pulmonary embolism but could replace angiography in combined strategies that include ultrasonography and lung scanning.

  • Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and d-dimer

    • Philip S. Wells,
    • David R. Anderson,
    • Marc Rodger,
    • Ian Stiell,
    • Jonathan F. Dreyer,
    • David Barnes,
    • Melissa Forgie,
    • George Kovacs,
    • John Ward,
    • and Michael J. Kovacs
    Ann Intern Med July 17, 2001 135:98-107

    Managing patients for suspected pulmonary embolism on the basis of pretest probability and d-dimer test result is safe and decreases the need for diagnostic imaging.

Brief Communications

  • Management of Suspected Deep Venous Thrombosis in Outpatients by Using Clinical Assessment and d-dimer Testing

    • Clive Kearon,
    • Jeffrey S. Ginsberg,
    • James Douketis,
    • Mark Crowther,
    • Patrick Brill-Edwards,
    • Jeffrey I. Weitz,
    • and Jack Hirsh
    Ann Intern Med July 17, 2001 135:108-111

    The combination of a low pretest probability of deep venous thrombosis and a negative result on a whole-blood d-dimer test rules out deep venous thrombosis in a large proportion of symptomatic outpatients.

Academia and Clinic

  • Adjustments for Center in Multicenter Studies: An Overview

    • A. Russell Localio,
    • Jesse A. Berlin,
    • Thomas R. Ten Have,
    • and Stephen E. Kimmel
    Ann Intern Med July 17, 2001 135:112-123

    Investigators increasingly rely on multicenter or multigroup studies to demonstrate effectiveness and generalizability. Authors too often overlook the analytic challenges in these study designs: the correlation of outcomes and exposures among patients within centers, confounding of associations by center, and effect modification of treatment or exposure across center.

Updates

  • Update in Dermatology

    • Rebecca A. Kazin,
    • Nancy R. Lowitt,
    • and Mark H. Lowitt
    Ann Intern Med July 17, 2001 135:124-132

    The authors highlight and discuss 10 articles from the past 2 years that illustrate progress in dermatologic areas of interest to the internist. Topics include hepatitis C virus infection, herpes simplex viruses, and common skin diseases such as basal-cell carcinoma.

Perspectives

  • Power Shortage: Clinical Trials Testing the “Homocysteine Hypothesis” against a Background of Folic Acid–Fortified Cereal Grain Flour

    • Andrew G. Bostom,
    • Jacob Selhub,
    • Paul F. Jacques,
    • and Irwin H. Rosenberg
    Ann Intern Med July 17, 2001 135:133-137

    Fortification of cereal grain flour with folic acid has dramatically affected the occurrence of mild hyperhomocysteinemia and responsiveness to total homocysteine–lowering treatment in people with cardiovascular disease who are free of chronic renal insufficiency. As a result, ongoing trials of total homocysteine–lowering therapy for the potential reduction of cardiovascular disease outcomes may be underpowered.

Editorial

  • The Effect of Angiotensin-Converting Enzyme Inhibitors on the Progression of Nondiabetic Renal Disease: A Pooled Analysis of Individual-Patient Data from 11 Randomized, Controlled Trials

    • Robert W. Schrier and
    • Raymond O. Estacio
    Ann Intern Med July 17, 2001 135:138-139

    Jafar and colleagues' meta-analysis in this issue contributes evidence on strategies to slow nondiabetic renal progression by use of angiotensin-converting enzyme inhibitors. However, the authors' conclusion, although perhaps correct, must be considered tentative.

Letters

  • Association of Hepatitis C and Diabetes Mellitus

    • Hilla Knobler and
    • A. Schattner
    Ann Intern Med July 17, 2001 135:141

  • Association of Hepatitis C and Diabetes Mellitus

    • Robert Paris
    Ann Intern Med July 17, 2001 135:141-142

  • Association of Hepatitis C and Diabetes Mellitus

    • Shruti H. Mehta,
    • Mark S. Sulkowski,
    • and David L. Thomas
    Ann Intern Med July 17, 2001 135:142

  • Cocaine-Related Vasculitis Causing Upper-Limb Peripheral Vascular Disease

    • Norm R.C. Campbell and
    • Nadia Khan
    Ann Intern Med July 17, 2001 135:142

  • Severe Hepatitis in a Patient Taking Cetirizine

    • Makoto Watanabe,
    • Naruaki Kohge,
    • and Takekazu Kaji
    Ann Intern Med July 17, 2001 135:142-143

Medical Writings: Book Notes

  • Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance

    • Nelson M. Gantz
    Ann Intern Med July 17, 2001 135:144

  • Menopause: Biology and Pathobiology

    • Lori A. Bastian
    Ann Intern Med July 17, 2001 135:144

Current Clinical Issues

Ad Libitum

Book Listings

Medical Notices

Summaries for Patients

  • Using a Type of Blood Pressure Medicine, Angiotensin-Converting Enzyme Inhibitors, To Prevent Worsening of Kidney Disease Unrelated to Diabetes

    Ann Intern Med July 17, 2001 135:S21

  • Detecting Pulmonary Emboli with Helical Computed Tomography

    Ann Intern Med July 17, 2001 135:S22

  • Improving the Diagnosis of Pulmonary Embolism in the Emergency Department

    Ann Intern Med July 17, 2001 135:S23

  • A New and Improved System for Excluding the Diagnosis of Deep Venous Thrombosis

    Ann Intern Med July 17, 2001 135:S24
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This Issue

July 17, 2001; 135 (2)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Updates
  5. Perspectives
  6. Editorial
  7. Letters
  8. Medical Writings: Book Notes
  9. Current Clinical Issues
  10. Ad Libitum
  11. Book Listings
  12. Medical Notices
  13. Summaries for Patients

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