Table of Contents

April 17, 2001; 134 (8)

Articles

  • Renal Insufficiency as a Predictor of Cardiovascular Outcomes and the Impact of Ramipril: The HOPE Randomized Trial

    • Johannes F.E. Mann,
    • Hertzel C. Gerstein,
    • Janice Pogue,
    • Jackie Bosch,
    • Salim Yusuf,
    • and for the HOPE Investigators
    Ann Intern Med April 17, 2001 134:629-636

    In patients who had preexisting vascular disease or diabetes combined with an additional cardiovascular risk factor, mild renal insufficiency significantly increased the risk for subsequent cardiovascular events. Ramipril reduced cardiovascular risk without increasing adverse effects.

  • Impact of Age on Perioperative Complications and Length of Stay in Patients Undergoing Noncardiac Surgery

    • Carísi A. Polanczyk,
    • Edward Marcantonio,
    • Lee Goldman,
    • Luis E.P. Rohde,
    • John Orav,
    • Carol M. Mangione,
    • and Thomas H. Lee
    Ann Intern Med April 17, 2001 134:637-643

    Elderly patients had a higher rate of major perioperative complications and mortality after noncardiac surgery and a longer length of stay compared with younger patients. Even in patients 80 years of age or older, however, mortality was low.

  • Treatment of Patients with Myocardial Infarction Who Present with a Paced Rhythm

    • Saif S. Rathore,
    • Kevin P. Weinfurt,
    • Bernard J. Gersh,
    • William J. Oetgen,
    • Kevin A. Schulman,
    • and Allen J. Solomon
    Ann Intern Med April 17, 2001 134:644-651

    Patients with paced rhythms were less likely than those without to receive treatment for acute myocardial infarction and had poorer short- and long-term outcomes. However, this mortality risk diminished after adjustment for treatment. This suggests that improved recognition and treatment of myocardial infarction may improve outcomes, particularly in the short term.

Brief Communications

  • Neocytolysis on Descent from Altitude: A Newly Recognized Mechanism for the Control of Red Cell Mass

    • Lawrence Rice,
    • Wilson Ruiz,
    • Theda Driscoll,
    • Carl E. Whitley,
    • Rosario Tapia,
    • David L. Hachey,
    • Gustavo F. Gonzales,
    • and Clarence P. Alfrey
    Ann Intern Med April 17, 2001 134:652-656

    This study confirms neocytolysis and the role of erythropoietin in persons with polycythemia who descend from high altitude. These findings may have implications that extend beyond space and altitude medicine to renal disease and other situations that involve erythropoietin suppression, hemolysis, and polycythemia.

Academia and Clinic

  • The CONSORT Statement: Revised Recommendations for Improving the Quality of Reports of Parallel-Group Randomized Trials

    • David Moher,
    • Kenneth F. Schulz,
    • Douglas G. Altman,
    • and for the CONSORT Group*
    Ann Intern Med April 17, 2001 134:657-662

    Investigators and editors developed the original CONSORT (ConsolidatedStandardsofReportingTrials) statement to help authors improve reporting of randomized, controlled trials by using a checklist and flow diagram. The revised CONSORT statement presented in this paper incorporates new evidence and addresses some criticisms of the original statement.

  • The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration

    • Douglas G. Altman,
    • Kenneth F. Schulz,
    • David Moher,
    • Matthias Egger,
    • Frank Davidoff,
    • Diana Elbourne,
    • Peter C. Gøtzsche,
    • Thomas Lang,
    • and for the CONSORT Group
    Ann Intern Med April 17, 2001 134:663-694

    The CONSORT statement facilitates critical appraisal and interpretation of randomized, controlled trials by providing guidance to authors about how to improve the reporting of their trials. This explanatory and elaboration document is intended to enhance the use, understanding, and dissemination of the CONSORT statement.

Review

  • Rational Use of New and Existing Disease-Modifying Agents in Rheumatoid Arthritis

    • Joel M. Kremer
    Ann Intern Med April 17, 2001 134:695-706

    In the past 2 years, three new disease-modifying antirheumatic drugs (DMARDs) have been approved: leflunomide, etanercept, and infliximab. Studies examining these drugs and existing DMARDs (sulfasalazine and hydroxychloroquine) in combination with methotrexate clearly demonstrate that clinical responses can be meaningfully improved when new and existing DMARDs are added to methotrexate.

Editorials

  • The Kidney in Cardiovascular Disease

    • Bertram L. Kasiske
    Ann Intern Med April 17, 2001 134:707-709

    In this issue, Mann and colleagues report that ramipril safely reduced risk for cardiovascular disease in patients with mild renal insufficiency and that mild renal insufficiency is an independent risk factor for cardiovascular disease. It may be more than coincidental that angiotensin-converting enzyme inhibitors seem both renoprotective and cardioprotective. Understanding the link between cardiovascular risk factors and kidney damage may be key to finding better ways to prevent and treat kidney and cardiovascular disease.

  • Out of Thin Air: The Evolving Enigma of Erythropoietin and Neocytolysis

    • Bernard A. Harris, Jr. and
    • Paul E. Epstein
    Ann Intern Med April 17, 2001 134:710-712

    As shown by Rice and colleagues' study in this issue, the lessons learned from space medicine have already produced some important information about neocytolysis. A deeper understanding of this process may be particularly helpful in exploring the expanding universe of possibilities.

Letters

  • Treatment of Heroin Dependence

    • Mark H. Hyman
    Ann Intern Med April 17, 2001 134:714

  • Treatment of Heroin Dependence

    • Patrick G. O'Connor and
    • David A. Fiellin
    Ann Intern Med April 17, 2001 134:714-715

  • Tattoo-Related Brachial Plexopathies with Adjacent Muscle Atrophy

    • Jeffrey John Post
    Ann Intern Med April 17, 2001 134:715

  • Tattoo-Related Brachial Plexopathies with Adjacent Muscle Atrophy

    • Israel Steiner and
    • Itzhak Wirguin
    Ann Intern Med April 17, 2001 134:715

  • Correction: Summary for Patients on Genes for Hemochromatosis

    • Victor Herbert
    Ann Intern Med April 17, 2001 134:715

Medical Writings: Book and Software Notes

  • Cardiology: The Evolution of the Science and the Art

    • Paul Kligfield
    Ann Intern Med April 17, 2001 134:716

  • Dynamic Practical Electrocardiography

    • Craig H. Scott and
    • Behzad B. Pavri
    Ann Intern Med April 17, 2001 134:716

Current Clinical Issues

  • Clinical Librarianship: Its Value in Medical Care

    • Loraine F. Schacher
    Ann Intern Med April 17, 2001 134:717-720

Book Listings

Medical Notices

Summaries for Patients

  • Trial of a Drug to Decrease the Risk for Heart Disease in Patients with Mild Kidney Failure

    Ann Intern Med April 17, 2001 134:S96

  • The Effect of Age on the Risk for Complications and Death after Noncardiac Surgery

    Ann Intern Med April 17, 2001 134:S97

  • Treatment and Outcomes of Heart Attacks in People with Pacemakers

    Ann Intern Med April 17, 2001 134:S98

  • A New Mechanism for Controlling the Number of Red Cells in the Blood

    Ann Intern Med April 17, 2001 134:S99
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This Issue

April 17, 2001; 134 (8)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Review
  5. Editorials
  6. Letters
  7. Medical Writings: Book and Software Notes
  8. Current Clinical Issues
  9. Book Listings
  10. Medical Notices
  11. Summaries for Patients

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