Table of Contents

January 16, 2001; 134 (2)

Articles

  • Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis

    • Bruce Y. Tung,
    • Mary J. Emond,
    • Rodger C. Haggitt,
    • Mary P. Bronner,
    • Michael B. Kimmey,
    • Kris V. Kowdley,
    • and Teresa A. Brentnall
    Ann Intern Med January 16, 2001 134:89-95

    Ursodiol use appears to be associated with a lower frequency of colonic dysplasia in patients with ulcerative colitis and primary sclerosing cholangitis. A randomized trial investigating the chemoprotective effect of ursodiol in patients with ulcerative colitis may be warranted.

  • Physical Activity and Risk for Cardiovascular Events in Diabetic Women

    • Frank B. Hu,
    • Meir J. Stampfer,
    • Caren Solomon,
    • Simin Liu,
    • Graham A. Colditz,
    • Frank E. Speizer,
    • Walter C. Willett,
    • and JoAnn E. Manson
    Ann Intern Med January 16, 2001 134:96-105

    Among diabetic women, increased physical activity, including regular walking, is associated with substantially reduced risk for cardiovascular events.

  • Combined Treatment of Giant-Cell Arteritis with Methotrexate and Prednisone: A Randomized, Double-Blind, Placebo-Controlled Trial

    • Juan A. Jover,
    • César Hernández-García,
    • Inmaculada C. Morado,
    • Emilio Vargas,
    • Antonio Bañares,
    • and Benjamín Fernández-Gutiérrez
    Ann Intern Med January 16, 2001 134:106-114

    Treatment with methotrexate plus corticosteroid is a safe alternative to corticosteroid therapy alone in patients with giant-cell arteritis and is more effective in controlling disease.

Brief Communications

  • Tropheryma whippelii DNA Is Rare in the Intestinal Mucosa of Patients without Other Evidence of Whipple Disease

    • Matthias Maiwald,
    • Axel von Herbay,
    • David H. Persing,
    • P. Shawn Mitchell,
    • Manal F. Abdelmalek,
    • Jill N. Thorvilson,
    • David N. Fredricks,
    • and David A. Relman
    Ann Intern Med January 16, 2001 134:115-119

    Tropheryma whippelii occurs only rarely in intestinal mucosa that lacks histopathologic evidence of Whipple disease. The human small intestinal mucosa is an unlikely reservoir for this organism.

  • The Relationship of Acute Transfusion-Associated Hepatitis to the Development of Cirrhosis in the Presence of Alcohol Abuse

    • D. Robert Harris,
    • René Gonin,
    • Harvey J. Alter,
    • Elizabeth C. Wright,
    • Zelma J. Buskell,
    • F. Blaine Hollinger,
    • Leonard B. Seeff,
    • and for the National Heart, Lung, and Blood Institute Study Group
    Ann Intern Med January 16, 2001 134:120-124

    Heavy alcohol abuse greatly exacerbates the risk for cirrhosis among patients with hepatitis C virus infection. This finding emphasizes the need to counsel such patients about their drinking habits.

Academia and Clinic

  • Social Marketing: Application to Medical Education

    • Sean P. David and
    • David S. Greer
    Ann Intern Med January 16, 2001 134:125-127

    The techniques of social marketing—goal identification, audience segmentation, and market research—have not been harnessed and applied to medical education. Social marketing can be applied to medical education in the effort to go beyond inoculation of learners with information and actually change behaviors.

Review

  • Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

    • Moisés Selman,
    • Talmadge E. King, Jr.,
    • and Annie Pardo
    Ann Intern Med January 16, 2001 134:136-151

    This review presents a growing body of evidence suggesting that idiopathic pulmonary fibrosis involves abnormal wound healing in response to multiple, microscopic sites of ongoing alveolar epithelial injury or activation associated with the formation of patchy fibroblast–myofibroblast foci, which evolve to fibrosis.

Perspectives

  • Breaking the Camel's Back: Multicenter Clinical Trials and Local Institutional Review Boards

    • William J. Burman,
    • Randall R. Reves,
    • David L. Cohn,
    • and Robert T. Schooley
    Ann Intern Med January 16, 2001 134:152-157

    The authors examine the problems underlying recent federal regulatory actions against institutional review boards.

Editorials

  • Chemoprevention in Ulcerative Colitis: Narrowing the Gap between Clinical Practice and Research

    • Ernest T. Hawk and
    • Jaye L. Viner
    Ann Intern Med January 16, 2001 134:158-160

    At present, it would be premature to offer ursodiol as a chemopreventive agent outside the context of a clinical trial. However, if the inverse association between ursodiol use and dysplasia prevalence described by Tung and colleagues in this issue is causal and true, it is a very exciting observation.

  • Institutional Review Boards: A Crisis in Confidence

    • Robert J. Levine
    Ann Intern Med January 16, 2001 134:161-163

    In this issue, Burman and coworkers identify the enormous increase in the number and complexity of multicenter randomized clinical trials as the root cause of the crisis in institutional review boards (IRBs). This editorial argues that although we must be concerned about the capabilities of IRBs to cope with multicenter trials, IRBs are not the major problem.

Letters

  • Indinavir, Zidovudine, Lamivudine: 3-Year Follow-up

    • Mark S. Dworkin and
    • Pei-Chun T. Wan
    Ann Intern Med January 16, 2001 134:165

  • Treatment of Heroin Dependence

    • Joseph O. Merrill and
    • Ron Jackson
    Ann Intern Med January 16, 2001 134:165-166

  • Cyclospora cayetanensis Cholecystitis in a Patient with AIDS

    • Miguel de Górgolas,
    • Jose Fortés,
    • and Manuel Luis Fernández Guerrero
    Ann Intern Med January 16, 2001 134:166

  • Conduction Disturbances Associated with Venlafaxine

    • Alain Combes,
    • Gilles Peytavin,
    • and David Théron
    Ann Intern Med January 16, 2001 134:166-167

Medical Writings: Book Notes

Current Clinical Issues

  • Reporting Standards and the Transparency of Trials

    • Aaron Levin
    Ann Intern Med January 16, 2001 134:169-172

Book Listings

Medical Notices

Summaries for Patients

  • Ursodiol Is Associated with Fewer Precancerous Abnormalities of the Colon in Certain Patients with Ulcerative Colitis

    Ann Intern Med January 16, 2001 134:S69

  • Physical Activity and the Risk for Heart Disease and Stroke in Women with Diabetes

    Ann Intern Med January 16, 2001 134:S70

  • Combining Methotrexate with Prednisone To Treat Temporal Arteritis

    Ann Intern Med January 16, 2001 134:S71

  • Tropheryma whippelii DNA Is Rare in the Intestines of Patients without Other Signs of Whipple Disease

    Ann Intern Med January 16, 2001 134:S72

  • Relationship among Transfusion-Related Hepatitis C, Alcohol Abuse, and Cirrhosis

    Ann Intern Med January 16, 2001 134:S73

Updates from the Annual Session

  • Update in Preventive Medicine

    • Laurence H. Beck
    Ann Intern Med January 16, 2001 134:128-135

    This Update focuses on areas of primary prevention (influenza and modifications in diet and behavior) and secondary prevention (osteoporosis and cardiovascular disease).

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This Issue

January 16, 2001; 134 (2)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Review
  5. Perspectives
  6. Editorials
  7. Letters
  8. Medical Writings: Book Notes
  9. Current Clinical Issues
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients
  13. Updates from the Annual Session

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