Table of Contents

May 15, 2001; 134 (10)

Articles

  • Benefits of Pravastatin on Cardiovascular Events and Mortality in Older Patients with Coronary Heart Disease Are Equal to or Exceed Those Seen in Younger Patients: Results from the LIPID Trial

    • David Hunt,
    • Peta Young,
    • John Simes,
    • Wendy Hague,
    • Stewart Mann,
    • Dwain Owensby,
    • Geoffrey Lane,
    • Andrew Tonkin,
    • and for the LIPID Investigators
    Ann Intern Med May 15, 2001 134:931-940

    In older patients with coronary heart disease and average or moderately elevated cholesterol levels, pravastatin therapy reduced the risk for all major cardiovascular events and all-cause mortality. Since older patients are at higher risk than younger patients for these events, the absolute benefit of treatment is significantly greater in older patients.

  • Angiotensinogen Mutations and Risk for Ischemic Heart Disease, Myocardial Infarction, and Ischemic Cerebrovascular Disease: Six Case–Control Studies from the Copenhagen City Heart Study

    • Amar A. Sethi,
    • Anne Tybjærg-Hansen,
    • Marie-Louise Moes Grønholdt,
    • Rolf Steffensen,
    • Peter Schnohr,
    • and Børge G. Nordestgaard
    Ann Intern Med May 15, 2001 134:941-954

    In six large case–control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease. Statistically significant associations may represent chance findings rather than real phenomena.

  • Survival in Academy Award–Winning Actors and Actresses

    • Donald A. Redelmeier and
    • Sheldon M. Singh
    Ann Intern Med May 15, 2001 134:955-962

    The association of high status with increased longevity that prevails in the public also extends to celebrities, contributes to a large survival advantage, and is partially explained by factors related to success.

Brief Communications

  • Effects of Long-Term Postoperative Interferon-α Therapy on Intrahepatic Recurrence after Resection of Hepatitis C Virus–Related Hepatocellular Carcinoma: A Randomized, Controlled Trial

    • Shoji Kubo,
    • Shuhei Nishiguchi,
    • Kazuhiro Hirohashi,
    • Hiromu Tanaka,
    • Taichi Shuto,
    • Osamu Yamazaki,
    • Susumu Shiomi,
    • Akihiro Tamori,
    • Hiroko Oka,
    • Sumito Igawa,
    • Tetsuo Kuroki,
    • and Hiroaki Kinoshita
    Ann Intern Med May 15, 2001 134:963-967

    Postoperative interferon-α therapy appears to decrease recurrence of cancer after resection of hepatitis C virus–related hepatocellular carcinoma.

Academia and Clinic

  • A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors

    • Honghu Liu,
    • Carol E. Golin,
    • Loren G. Miller,
    • Ron D. Hays,
    • C. Keith Beck,
    • Sam Sanandaji,
    • Judith Christian,
    • Tomasa Maldonado,
    • Dena Duran,
    • Andrew H. Kaplan,
    • and Neil S. Wenger
    Ann Intern Med May 15, 2001 134:968-977

    This study examined the relationship between a composite score of three measures of drug adherence and HIV virologic response. The authors found that different measures applied to the same patient suggest different levels of adherence. Adherence may be underestimated by an electronic measurement device and may be overestimated by pill count and interview. A summary measure is more strongly related to a clinical response, but more practical measurement methods are needed for clinical use.

Review

  • Host Determinants in HIV Infection and Disease: Part 2: Genetic Factors and Implications for Antiretroviral Therapeutics*

    • Christine M. Hogan and
    • Scott M. Hammer
    Ann Intern Med May 15, 2001 134:978-996

    This paper, the second of two reviewing the role of host factors in HIV infection, discusses the role of genetic host factors—inheritance of mutant chemokine receptors or ligands as well as HLA type—in susceptibility to infection with HIV and subsequent clinical course. The effects of soluble inhibitory factors, the cytokine milieu, and concomitant infections are also described.

Perspectives

  • General Internal Medicine at the Crossroads of Prosperity and Despair: Caring for Patients with Chronic Diseases in an Aging Society

    • Eric B. Larson
    Ann Intern Med May 15, 2001 134:997-1000

    The instability of today's medical marketplace makes the future of general internal medicine uncertain. To thrive, general internal medicine must build on its strengths within the medical marketplace, seize the opportunities offered by demographic changes, and take a primary role in serving the needs of older patients with chronic diseases.

Editorials

  • Social Status and Mortality

    • Ray Fitzpatrick
    Ann Intern Med May 15, 2001 134:1001-1003

    Accumulating evidence suggests that social status itself, regardless of associated material and economic advantages, may confer health benefits. In this issue, Redelmeier and Singh provide further intriguing evidence by showing that actors and actresses who win Academy Awards live an average of 3.9 years longer than comparable performers who were nominated for an award but did not win.

  • Improving on a Coin Toss To Predict Patient Adherence to Medications

    • Barbara J. Turner and
    • Frederick M. Hecht
    Ann Intern Med May 15, 2001 134:1004-1006

    Liu and colleagues' article in this issue contributes to the field of adherence measurement by showing improved predictive validity after incorporation of data from several adherence measures when data from an electronic monitor were missing. At this point, patient interview remains the most practical approach for clinicians, while a combination of adherence measures seems to be optimal for research purposes.

Letters

Medical Writings: Book Notes

  • Streptococcal Infections: Clinical Aspects, Microbiology, and Molecular Pathogenesis

    • Nicholas J. Lekas
    Ann Intern Med May 15, 2001 134:1010

  • Textbook of Lung Cancer

    • Michael C. Perry
    Ann Intern Med May 15, 2001 134:1010

Current Clinical Issues

Book Listings

Medical Notices

Summaries for Patients

  • Benefits of Lowering Cholesterol Levels in Older Patients

    Ann Intern Med May 15, 2001 134:S4

  • Mutations of the Angiotensinogen Gene and the Risk for Heart Disease and Stroke

    Ann Intern Med May 15, 2001 134:S5

  • Social Status and Life Expectancy in an Advantaged Population: A Study of Academy Award–Winning Actors

    Ann Intern Med May 15, 2001 134:S6

  • Does Interferon-α Prevent Recurrence of Malignant Tumors in Patients with Hepatitis C–Related Liver Cancer?

    Ann Intern Med May 15, 2001 134:S7
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This Issue

May 15, 2001; 134 (10)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Review
  5. Perspectives
  6. Editorials
  7. Letters
  8. Medical Writings: Book Notes
  9. Current Clinical Issues
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients

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