Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 1: Ethical and Scientific Issues

Appendix Figure. Hypothetical results of five studies are shown. The result of each study is shown on the y-axis as the difference between treatments (E − E ), where represents the control and represents the test drug. A positive difference favors the standard drug. Error bars show hypothetical 95% CIs for these differences. Three possible noninferiority margins are shown (M0, M1, M2). For more explanation, see the .
Appendix Figure. Hypothetical results of five studies are shown. The result of each study is shown on the y-axis as the difference between treatments (E − E ), where represents the control and represents the test drug. A positive difference favors the standard drug. Error bars show hypothetical 95% CIs for these differences. Three possible noninferiority margins are shown (M0, M1, M2). For more explanation, see the . Interpretation of equivalence margins in active-control trials.STESETAppendix

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  1. Ann Intern Med September 19, 2000 vol. 133 no. 6 455-463
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