Table of Contents

September 19, 2000; 133 (6)

Articles

  • Clinical Outcome of Patients with HIV-1 Infection according to Immunologic and Virologic Response after 6 Months of Highly Active Antiretroviral Therapy

    • Sophie Grabar,
    • Vincent Le Moing,
    • Cécile Goujard,
    • Catherine Leport,
    • Michel D. Kazatchkine,
    • Dominique Costagliola,
    • and Laurence Weiss
    Ann Intern Med September 19, 2000 133:401-410

    Immunologic response after 6 months of highly active antiretroviral therapy indicates a favorable clinical outcome in HIV-infected patients regardless of virologic response. This finding suggests that both immunologic and virologic markers should be used in clinical practice to evaluate treatment response.

  • Type of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer

    • Morten Grønbæk,
    • Ulrik Becker,
    • Ditte Johansen,
    • Adam Gottschau,
    • Peter Schnohr,
    • Hans Ole Hein,
    • Gorm Jensen,
    • and Thorkild I.A. Sørensen
    Ann Intern Med September 19, 2000 133:411-419

    This study suggests that wine intake may have a beneficial effect on all-cause mortality that is additive to the effect of alcohol. This effect may be attributable to a reduction in death from both coronary heart disease and cancer.

  • Garlic for Treating Hypercholesterolemia: A Meta-Analysis of Randomized Clinical Trials

    • Clare Stevinson,
    • Max H. Pittler,
    • and Edzard Ernst
    Ann Intern Med September 19, 2000 133:420-429

    The available data suggest that garlic is superior to placebo in reducing total cholesterol levels. However, the size of the effect is modest, and its robustness is debatable. The use of garlic for hypercholesterolemia is therefore of questionable value.

Brief Communications

  • Retroviral Rebound Syndrome after Cessation of Suppressive Antiretroviral Therapy in Three Patients with Chronic HIV Infection

    • Roy Colven,
    • Robert D. Harrington,
    • David H. Spach,
    • Calvin J. Cohen,
    • and Thomas M. Hooton
    Ann Intern Med September 19, 2000 133:430-434

    A retroviral rebound syndrome similar to that seen in primary HIV syndrome can occur in patients with chronic HIV infection after cessation of suppressive antiretroviral therapy.

  • Recurrence of the Acute HIV Syndrome after Interruption of Antiretroviral Therapy in a Patient with Chronic HIV Infection: A Case Report

    • J. Michael Kilby,
    • Paul A. Goepfert,
    • Andrew P. Miller,
    • John W. Gnann, Jr.,
    • Michael Sillers,
    • Michael S. Saag,
    • and R. Pat Bucy
    Ann Intern Med September 19, 2000 133:435-438

    Interruption of therapy may be associated with profound viral rebound and recurrence of the acute HIV syndrome.

Review

  • Inflammatory Reactions in HIV-1–Infected Persons after Initiation of Highly Active Antiretroviral Therapy

    • Joseph A. DeSimone,
    • Roger J. Pomerantz,
    • and Timothy J. Babinchak
    Ann Intern Med September 19, 2000 133:447-454

    Clinicians caring for HIV-1–infected patients who are receiving highly active antiretroviral therapy must be aware of inflammatory reactions involving opportunistic infections, AIDS-associated malignant conditions, and infectious diseases.

Medicine and Public Issues

  • Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 1: Ethical and Scientific Issues

    • Robert Temple and
    • Susan S. Ellenberg
    Ann Intern Med September 19, 2000 133:455-463

    Part one of this two-part article considers the ethical concerns about the use of placebo controls and describes the limited ability of active-control equivalence trials to establish efficacy of new therapies in many medical contexts.

  • Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 2: Practical Issues and Specific Cases

    • Susan S. Ellenberg and
    • Robert Temple
    Ann Intern Med September 19, 2000 133:464-470

    Part two of this two-part article discusses more fully the ethical considerations for using placebo controls in particular settings. The value and relevance of placebo-controlled trials of new agents in situations in which proven effective therapy is available are also explored.

Editorials

  • Assessing the Benefits of Antiretroviral Therapy

    • Roy M. Gulick
    Ann Intern Med September 19, 2000 133:471-473

    Grabar and colleagues' study in this issue points to the importance of assessing the virologic and immunologic responses to treatment in the context of the underlying pathogenetic process. By doing so, we will be able to reach the ultimate goal of antiretroviral therapy: to prevent illness and prolong survival among HIV-infected patients.

  • Are Placebo-Controlled Clinical Trials Ethical or Needed When Alternative Treatment Exists?

    • Richard Simon
    Ann Intern Med September 19, 2000 133:474-475

    In this issue, Temple and Ellenberg address the ethical challenge presented by use of placebo controls. Under what circumstances are placebo controls ethical, and what alternatives are available?

On Being a Doctor

  • A Model Death

    • Jack Coulehan
    Ann Intern Med September 19, 2000 133:477-478

    To many health professionals, the ideal patient just lies there quietly and cooperatively, watching television between occasional bouts of meaningful interaction with his family. Bob didn't measure up to this standard.

On Being a Patient

  • Under Toad Days: Surviving the Uncertainty of Cancer Recurrence

    • Elizabeth D. McKinley
    Ann Intern Med September 19, 2000 133:479-480

    The Under Toad in John Irving's novel The World According to Garp is a grim symbol of the uncertainty of recurrence that patients with cancer face.

Letters

  • Generalist and Cardiologist Care for Congestive Heart Failure

    • M.A. Nurhussein
    Ann Intern Med September 19, 2000 133:481

  • Generalist and Cardiologist Care for Congestive Heart Failure

    • Sanjay Srivatsa and
    • Hamid R. Amjadi
    Ann Intern Med September 19, 2000 133:481-482

  • Generalist and Cardiologist Care for Congestive Heart Failure

    • Andrew D. Auerbach,
    • Russell S. Phillips,
    • and Mary Beth Hamel
    Ann Intern Med September 19, 2000 133:482

  • Protease Inhibitors and Prohormone Processing

    • Raphael B. Stricker and
    • Billi Goldberg
    Ann Intern Med September 19, 2000 133:482-483

  • Protease Inhibitors and Prohormone Processing

    • Ann Danoff and
    • Wai Lam W. Ling
    Ann Intern Med September 19, 2000 133:483

  • Helical Computed Tomography for Diagnosing Pulmonary Embolism

    • John R. Mayo,
    • Elisabeth M. Baile,
    • and Peter D. Pare
    Ann Intern Med September 19, 2000 133:483-484

  • Helical Computed Tomography for Diagnosing Pulmonary Embolism

    • Suman W. Rathbun,
    • Gary E. Raskob,
    • and Thomas L. Whitsett
    Ann Intern Med September 19, 2000 133:484

  • Richard Lower: Anatomist and Physiologist

    • Shakaib U. Rehman,
    • Ambreen Shakaib,
    • and Shaukat Rashid
    Ann Intern Med September 19, 2000 133:484-485

  • Richard Lower: Anatomist and Physiologist

    • John H. Felts
    Ann Intern Med September 19, 2000 133:485

  • Hyponatremia Associated with Quinupristin–Dalfopristin

    • Randolph P. Cole,
    • W. Daniel Roberts,
    • and Matthew D. Cheng
    Ann Intern Med September 19, 2000 133:485

  • Hospital Measures for Prevention of Tuberculosis Transmission in U.S. Cities with and without Previous Nosocomial Tuberculosis Outbreaks

    • Charles L. Bennett,
    • Jennie B. Hounshell,
    • and Joan S. Chmiel
    Ann Intern Med September 19, 2000 133:486

Medical Writings: Book Notes

  • Herbal Medicine: Expanded Commission E Monographs

    • Michael Rotblatt
    Ann Intern Med September 19, 2000 133:487

  • American Pharmaceutical Association Practical Guide to Natural Medicines

    • Marc S. Micozzi
    Ann Intern Med September 19, 2000 133:487

  • William Osler: A Life in Medicine

    • Harvey Rubin
    Ann Intern Med September 19, 2000 133:488

Current Clinical Issues

  • HIV Vaccines: Inch by Inch

    • Brigid Kane
    Ann Intern Med September 19, 2000 133:489-490

  • The Ethics of Placebo-Controlled Trials

    • Tom Reynolds
    Ann Intern Med September 19, 2000 133:491-492

Book Listings

Medical Notices

  • Medical Notices

    Ann Intern Med September 19, 2000 133:0

Summaries for Patients

  • Cell Count, Viral Load, and Clinical Outcome in Patients with HIV Infection after Highly Active Antiretroviral Therapy

    Ann Intern Med September 19, 2000 133:I-16

  • The Relationship between Type of Alcoholic Drinks Consumed and Death from Various Causes

    Ann Intern Med September 19, 2000 133:I-22

  • Garlic as a Treatment for High Cholesterol

    Ann Intern Med September 19, 2000 133:I-31

  • A Report of Three HIV-Infected Patients Who Became Acutely Ill after Stopping Their Anti-HIV Treatment

    Ann Intern Med September 19, 2000 133:I-37

  • Patient Who Became Acutely Ill after Stopping Anti-HIV Treatment

    Ann Intern Med September 19, 2000 133:I-46

Updates from the Annual Session

  • Update in Cardiology

    • Kim A. Eagle
    Ann Intern Med September 19, 2000 133:439-446

    Among the topics covered in this Update are the prevention of coronary artery disease, use of antithrombins, and treatment of congestive heart failure.

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This Issue

September 19, 2000; 133 (6)
  1. Articles
  2. Brief Communications
  3. Review
  4. Medicine and Public Issues
  5. Editorials
  6. On Being a Doctor
  7. On Being a Patient
  8. Letters
  9. Medical Writings: Book Notes
  10. Current Clinical Issues
  11. Book Listings
  12. Medical Notices
  13. Summaries for Patients
  14. Updates from the Annual Session

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