Lactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases
- Kirk D. Miller, MD;
- Miriam Cameron, MD;
- Lauren V. Wood, MD;
- Marinos C. Dalakas, MD; and
- Joseph A. Kovacs, MD
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From Warren Grant Magnuson Clinical Center, National Institute of Allergy and Infectious Diseases Intramural AIDS Program,
National Cancer Institute, and National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda,
Maryland; and Kaiser Permanente Mid-Atlantic and West End Medical Center, Washington, D.C.
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Figure. Computed tomographic scan of patient 4's abdomen, showing diffusely hypodense liver compared with spleen of normal
density. These findings are consistent with fatty infiltration. Liver biopsy specimen from patient 1 showing extensive microvesicular
and macrovesicular hepatic steatosis (hematoxylin–eosin stain; magnification, ×200). Frozen cross-section of skeletal muscle
biopsy sample from patient 4, demonstrating abundant lipid droplets within the muscle fibers (oil red O stain; magnification,
×400). Electron µgraph of skeletal muscle from patient 4, showing subsarcolemmal accumulation of lipids (magnification, ×15
000). Computed tomographic, biopsy, and electron µgraph findings.A.B.C.D.
- Copyright ©2004 by the American College of Physicians
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Ann Intern Med
August 1, 2000
vol. 133
no. 3
192-196
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Figure. Computed tomographic scan of patient 4's abdomen, showing diffusely hypodense liver compared with spleen of normal density. These findings are consistent with fatty infiltration. Liver biopsy specimen from patient 1 showing extensive microvesicular and macrovesicular hepatic steatosis (hematoxylin–eosin stain; magnification, ×200). Frozen cross-section of skeletal muscle biopsy sample from patient 4, demonstrating abundant lipid droplets within the muscle fibers (oil red O stain; magnification, ×400). Electron µgraph of skeletal muscle from patient 4, showing subsarcolemmal accumulation of lipids (magnification, ×15 000). Computed tomographic, biopsy, and electron µgraph findings.A.B.C.D.
