Table of Contents

December 19, 2000; 133 (12)

Articles

  • A Prospective, Observational Study of Postmenopausal Hormone Therapy and Primary Prevention of Cardiovascular Disease

    • Francine Grodstein,
    • JoAnn E. Manson,
    • Graham A. Colditz,
    • Walter C. Willett,
    • Frank E. Speizer,
    • and Meir J. Stampfer
    Ann Intern Med December 19, 2000 133:933-941

    Postmenopausal hormone use appears to decrease risk for major coronary events in women without previous heart disease. Furthermore, 0.3 mg of oral conjugated estrogen daily is associated with a reduction similar to that seen with the standard dose of 0.625 mg. However, estrogen at daily doses of 0.625 mg or greater and in combination with progestin may increase risk for stroke.

  • The Positive Predictive Value of Cervical Smears in Previously Screened Postmenopausal Women: The Heart and Estrogen/progestin Replacement Study (HERS)

    • George F. Sawaya,
    • Deborah Grady,
    • Karla Kerlikowske,
    • June La Valleur,
    • Vanessa M. Barnabei,
    • Katherine Bass,
    • Thomas E. Snyder,
    • James H. Pickar,
    • Sanjay K. Agarwal,
    • Jeanne Mandelblatt,
    • and for the Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    Ann Intern Med December 19, 2000 133:942-950

    Because of a poor positive predictive value, cervical smears should not be performed within 2 years of normal cytologic results in postmenopausal women. Therapy with oral estrogen plus progestin does not significantly affect the incidence of cytologic abnormalities.

  • Association of Hypogonadism and Estradiol Levels with Bone Mineral Density in Elderly Men from the Framingham Study

    • Shreyasee Amin,
    • Yuqing Zhang,
    • Clark T. Sawin,
    • Stephen R. Evans,
    • Marian T. Hannan,
    • Douglas P. Kiel,
    • Peter W.F. Wilson,
    • and David T. Felson
    Ann Intern Med December 19, 2000 133:951-963

    In elderly men, hypogonadism related to aging has little influence on bone mineral density, but serum estradiol levels have a strong and positive association with this measure.

Brief Communications

  • Severe Liver Injury after Treatment with the Leukotriene Receptor Antagonist Zafirlukast

    • John F. Reinus,
    • Seth Persky,
    • Jill S. Burkiewicz,
    • David Quan,
    • Nathan M. Bass,
    • and Timothy J. Davern
    Ann Intern Med December 19, 2000 133:964-968

    Patients receiving zafirlukast may develop severe liver injury and should be observed for signs and symptoms of hepatitis.

  • Cardiovascular Effects of 3,4-Methylenedioxymethamphetamine: A Double-Blind, Placebo-Controlled Trial

    • Steven J. Lester,
    • Matthew Baggott,
    • Susette Welm,
    • Nelson B. Schiller,
    • Reese T. Jones,
    • Elyse Foster,
    • and John Mendelson
    Ann Intern Med December 19, 2000 133:969-973

    Modest oral doses of MDMA (the psychoactive stimulant commonly known as ecstasy) increase heart rate, blood pressure, and myocardial oxygen consumption in a magnitude similar to that seen with dobutamine, 20 to 40 µg/kg per minute. Unlike dobutamine, MDMA has no measurable inotropic effects.

Perspectives

  • Influenza: Prospects for Control

    • Robert B. Couch
    Ann Intern Med December 19, 2000 133:992-998

    Reducing influenza to a minor medical problem will require approval of the live attenuated vaccine, development of better inactivated vaccines, availability of better rapid diagnostic methods, additions to the current antiviral options, and optimal application of all available methods.

Editorials

  • Hormones To Prevent Coronary Disease in Women: When Are Observational Studies Adequate Evidence?

    • Deborah Grady and
    • Stephen B. Hulley
    Ann Intern Med December 19, 2000 133:999-1001

    Despite strong observational evidence from the Nurses' Health Study (including that reported by Grodstein and colleagues in this issue) and others, the disappointing results of three recent trials indicate that clinicians should not use hormone therapy for prevention of coronary disease until this practice is supported by evidence from randomized trials.

  • Androgens, Estrogens, and Bone in Men

    • Ronald S. Swerdloff and
    • Christina Wang
    Ann Intern Med December 19, 2000 133:1002-1004

    In this issue, Amin and colleagues report a lack of relationship between serum levels of total testosterone and bone mineral density in older men. However, they found a strong positive correlation between serum estradiol level and bone mineral density. These data are of considerable interest and require careful interpretation because they may have implications for management of older men using androgen replacement treatment.

On Being a Doctor

  • The Department of Card Tricks and Close Magic

    • Itzhak Kronzon
    Ann Intern Med December 19, 2000 133:1005-1007

    The techniques of close-magic tricks and a procedure in the catheterization lab have some things in common.

Letters

  • Management of Suspected Ventilator-Associated Pneumonia

    • James R. Johnson
    Ann Intern Med December 19, 2000 133:1008

  • Management of Suspected Ventilator-Associated Pneumonia

    • Santiago Ewig,
    • Michael Niederman,
    • and Antoni Torres
    Ann Intern Med December 19, 2000 133:1008-1009

  • Management of Suspected Ventilator-Associated Pneumonia

    • Jean-Yves Fagon and
    • Jean Chastre
    Ann Intern Med December 19, 2000 133:1009

  • Liver Disease and Home Parenteral Nutrition

    • Karen C. McCowen,
    • Peter A. Burke,
    • and Bruce R. Bistrian
    Ann Intern Med December 19, 2000 133:1009-1010

  • Noncardiogenic Pulmonary Edema in Marathon Runners

    • Arthur J. Siegel
    Ann Intern Med December 19, 2000 133:1010

  • Noncardiogenic Pulmonary Edema in Marathon Runners

    • Eelco F.M. Wijdicks
    Ann Intern Med December 19, 2000 133:1010-1011

  • Noncardiogenic Pulmonary Edema in Marathon Runners

    • J. Carlos Ayus and
    • Allen I. Arieff
    Ann Intern Med December 19, 2000 133:1011

Medical Writings: Book Notes

  • Primary Care Provider's Guide to Cardiology

    • Richard S. Rees
    Ann Intern Med December 19, 2000 133:1012

  • Gastrointestinal Disease in Primary Care

    • Jean-Pierre Raufman
    Ann Intern Med December 19, 2000 133:1012

Current Clinical Issues

  • Developments in Cervical and Ovarian Cancer Screening: Implications for Current Practice

    • Gina Rollins
    Ann Intern Med December 19, 2000 133:1021-1024

Thanks to Reviewers

Book Listings

Medical Notices

Summaries for Patients

  • Postmenopausal Hormone Use and Primary Prevention of Heart Disease and Stroke in Healthy Women

    Ann Intern Med December 19, 2000 133:S60

  • The Value of Continuing Regular Papanicolaou (Pap) Smears in Postmenopausal Women

    Ann Intern Med December 19, 2000 133:S61

  • Levels of Testosterone and Estrogen and Bone Density in Elderly Men

    Ann Intern Med December 19, 2000 133:S62

  • Severe Liver Injury in Patients Taking the Asthma Medication Zafirlukast

    Ann Intern Med December 19, 2000 133:S63

  • Cardiovascular Effects of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

    Ann Intern Med December 19, 2000 133:S64

Updates from the Annual Session

  • Update in Critical Care Medicine

    • Robert Fromm, Jr. and
    • Kalpalatha Guntupalli
    Ann Intern Med December 19, 2000 133:974-980

    The studies summarized in this Update illustrate how relatively simple ideas and solutions in the intensive care unit can reduce mortality and complication rates and save costs.

  • Uncomplicated Acute Bronchitis

    • Ralph Gonzales and
    • Merle A. Sande
    Ann Intern Med December 19, 2000 133:981-991

    The authors describe recent developments in the pathophysiology, evaluation, and treatment of uncomplicated acute bronchitis and discuss the impact of efforts to reduce prescription of antibiotics for this illness.

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This Issue

December 19, 2000; 133 (12)
  1. Articles
  2. Brief Communications
  3. Perspectives
  4. Editorials
  5. On Being a Doctor
  6. Letters
  7. Medical Writings: Book Notes
  8. Current Clinical Issues
  9. Thanks to Reviewers
  10. Book Listings
  11. Medical Notices
  12. Summaries for Patients
  13. Updates from the Annual Session

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