Table of Contents

March 21, 2000; 132 (6)

Articles

  • Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease: A Randomized, Controlled Trial

    • David B. Badesch,
    • Victor F. Tapson,
    • Michael D. McGoon,
    • Bruce H. Brundage,
    • Lewis J. Rubin,
    • Fredrick M. Wigley,
    • Stuart Rich,
    • Robyn J. Barst,
    • Pamela S. Barrett,
    • Kenneth M. Kral,
    • Maria M. Jöbsis,
    • James E. Loyd,
    • Srinivas Murali,
    • Adaani Frost,
    • Reda Girgis,
    • Robert C. Bourge,
    • David D. Ralph,
    • C. Gregory Elliott,
    • Nicholas S. Hill,
    • David Langleben,
    • Robert J. Schilz,
    • Vallerie V. McLaughlin,
    • Ivan M. Robbins,
    • Bertron M. Groves,
    • Shelley Shapiro,
    • Thomas A. Medsger, Jr.,
    • Sean P. Gaine,
    • Evelyn Horn,
    • James C. Decker,
    • and Katharine Knobil
    Ann Intern Med March 21, 2000 132:425-434

    Continuous epoprostenol therapy improves exercise capacity and cardiopulmonary hemodynamics in patients with pulmonary hypertension due to the scleroderma spectrum of disease.

  • Inhaled Iloprost To Treat Severe Pulmonary Hypertension: An Uncontrolled Trial

    • Horst Olschewski,
    • H. Ardeschir Ghofrani,
    • Thomas Schmehl,
    • Jörg Winkler,
    • Heinrike Wilkens,
    • Marius M. Höper,
    • Jürgen Behr,
    • Franz-Xaver Kleber,
    • Werner Seeger,
    • and for the German PPH Study Group*
    Ann Intern Med March 21, 2000 132:435-443

    Inhaled iloprost may offer a new therapeutic option for improvement of hemodynamics and physical function in patients with life-threatening pulmonary hypertension and progressive right-heart failure that is refractory to conventional therapy.

  • Calcific Constrictive Pericarditis: Is It Still with Us?

    • Lieng H. Ling,
    • Jae K. Oh,
    • Jerome F. Breen,
    • Hartzell V. Schaff,
    • Gordon K. Danielson,
    • Douglas W. Mahoney,
    • James B. Seward,
    • and A. Jamil Tajik
    Ann Intern Med March 21, 2000 132:444-450

    In contrast to common belief, pericardial calcification was noted to be a frequent finding in patients with constrictive pericarditis. It is often associated with idiopathic disease and other markers of disease chronicity and is an independent predictor of increased perioperative mortality rates.

  • Understanding Economic and Other Burdens of Terminal Illness: The Experience of Patients and Their Caregivers

    • Ezekiel J. Emanuel,
    • Diane L. Fairclough,
    • Julia Slutsman,
    • and Linda L. Emanuel
    Ann Intern Med March 21, 2000 132:451-459

    Substantial care needs are an important cause of the economic and noneconomic burdens imposed by terminal illness. Through an empathetic approach, physicians may be able to ameliorate some of these burdens.

Medicine and Public Issues

  • Assisted Suicide: Finding Common Ground

    • Lois Snyder and
    • Arthur L. Caplan
    Ann Intern Med March 21, 2000 132:468-469

    The five papers on assisted suicide in this issue should help advance the dialogue about this difficult ethical subject and should be of assistance to physicians who grapple with these issues in practice, not just on paper.

  • Assisted Suicide Compared with Refusal of Treatment: A Valid Distinction?

    • Franklin G. Miller,
    • Joseph J. Fins,
    • Lois Snyder,
    • and for the University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel
    Ann Intern Med March 21, 2000 132:470-475

    This paper uses three illustrative cases to examine leading arguments for and against the recognition of a fundamental difference between physician-assisted suicide and refusal of life-sustaining treatment.

  • The Role of Guidelines in the Practice of Physician-Assisted Suicide

    • Arthur L. Caplan,
    • Lois Snyder,
    • Kathy Faber-Langendoen,
    • and for the University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel
    Ann Intern Med March 21, 2000 132:476-481

    The debate about assisted suicide guidelines involves several questions: What goals are guidelines intended to serve? Who should formulate guidelines? Can guidelines be practical? This paper explores these and other questions as physician-assisted suicide becomes legal.

  • Should Assisted Suicide Be Only Physician Assisted?

    • Kathy Faber-Langendoen,
    • Jason H.T. Karlawish,
    • and for the University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel
    Ann Intern Med March 21, 2000 132:482-487

    The discussion in this paper defines both the necessity and limits of the physician's role in assisted suicide by asking whether assisted suicide should be only physician assisted. Although physician involvement is necessary, the authors argue that it is not sufficient to ensure that patients requesting assisted suicide receive the best care.

  • Palliative Treatments of Last Resort: Choosing the Least Harmful Alternative

    • Timothy E. Quill,
    • Barbara Coombs Lee,
    • Sally Nunn,
    • and for the University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel
    Ann Intern Med March 21, 2000 132:488-493

    Methods for easing death include standard pain management, forgoing life-sustaining therapy, voluntarily stopping eating and drinking, terminal sedation, and physician-assisted suicide. This paper uses summaries of real clinical cases to illustrate how and when each of these practices might be chosen.

  • Responding to Legal Requests for Physician-Assisted Suicide

    • James A. Tulsky,
    • Ralph Ciampa,
    • Elliott J. Rosen,
    • and for the University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel
    Ann Intern Med March 21, 2000 132:494-499

    The authors articulate some of the conceptual challenges to assisted suicide inherent in an era of legalization and provide a framework for physicians to use when responding to requests for assistance in dying.

Editorial

  • Epoprostenol (Prostacyclin) and Pulmonary Hypertension

    • Alfred P. Fishman
    Ann Intern Med March 21, 2000 132:500-502

    Two studies in this issue tackle treatment of secondary pulmonary hypertension with intravenous prostacyclin (Badesch and colleagues) and treatment of primary pulmonary hypertension with inhaled iloprost, the stable analogue of prostacyclin (Olschewski and colleagues). Despite their limitations, these studies are pioneering efforts in different stages of evolution.

On Being a Doctor

  • Death with Dignity: A Case Study

    • Walter J. Kade
    Ann Intern Med March 21, 2000 132:504-506

    Within months after the Death with Dignity Act became law in Oregon, I received a call from the parents of a patient of mine requesting that I assist their daughter in her death.

Letters

  • Toward Evidence-Based Statistics

    • Daniel P. Sulmasy
    Ann Intern Med March 21, 2000 132:507

  • Toward Evidence-Based Statistics

    • Thomas Morgan
    Ann Intern Med March 21, 2000 132:507

  • Toward Evidence-Based Statistics

    • Jean-Francois Caubet
    Ann Intern Med March 21, 2000 132:507-508

  • Toward Evidence-Based Statistics

    • Steven Goodman
    Ann Intern Med March 21, 2000 132:508

  • Cost-Effectiveness of Low-Molecular-Weight Heparins for Deep Venous Thrombosis

    • Brendan M. Reilly and
    • Arthur Evans
    Ann Intern Med March 21, 2000 132:508

  • Cost-Effectiveness of Low-Molecular-Weight Heparins for Deep Venous Thrombosis

    • Michael K. Gould and
    • Alan M. Garber
    Ann Intern Med March 21, 2000 132:508-509

  • Antiretroviral Therapy for Pregnant HIV-Infected Women

    • Andrew D. Luber and
    • Betty J. Dong
    Ann Intern Med March 21, 2000 132:509

  • A New Role of Upper Gastrointestinal Endoscopy

    • Shoji Ozawa,
    • Takao Ozawa,
    • and Masato Odawara
    Ann Intern Med March 21, 2000 132:510

  • Methylphenidate for Cerebral Palsy with Choreoathetosis

    • Willem Boogerd and
    • Jos H. Beijnen
    Ann Intern Med March 21, 2000 132:510

  • FK506-Induced Autoimmune Diabetes

    • Toshihide Kawai,
    • Akira Shimada,
    • and Akira Kasuga
    Ann Intern Med March 21, 2000 132:511

Medical Writings: Book Notes

Currents

  • Research on Humans Faces Scrutiny: New Policies Adopted

    • Paul T. Kefalides
    Ann Intern Med March 21, 2000 132:513-516

Book Listings

Medical Notices

  • Medical Notices

    Ann Intern Med March 21, 2000 132:0

Summaries for Patients

  • The Efficacy of the Drug Epoprostenol in the Treatment of Pulmonary Hypertension Associated with Scleroderma

    Ann Intern Med March 21, 2000 132:425

  • Inhaled Iloprost to Treat Severe Pulmonary Hypertension

    Ann Intern Med March 21, 2000 132:435

  • Calcific Constrictive Pericarditis

    Ann Intern Med March 21, 2000 132:444

  • Understanding the Economic and Other Burdens of Terminal Illness for Patients and Their Caregivers

    Ann Intern Med March 21, 2000 132:451

Updates from the Annual Session

  • Update in Hepatology

    • Eugene R. Schiff
    Ann Intern Med March 21, 2000 132:460-466

    This Update addresses key research in the areas of viral hepatitis, drug-induced hepatotoxicity, and noninvasive diagnostic assessment using magnetic resonance cholangiography.

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This Issue

March 21, 2000; 132 (6)
  1. Articles
  2. Medicine and Public Issues
  3. Editorial
  4. On Being a Doctor
  5. Letters
  6. Medical Writings: Book Notes
  7. Currents
  8. Book Listings
  9. Medical Notices
  10. Summaries for Patients
  11. Updates from the Annual Session

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