Table of Contents

February 15, 2000; 132 (4)

Articles

  • Effects of Infant Birthweight and Maternal Body Mass Index in Pregnancy on Components of the Insulin Resistance Syndrome in China

    • Jie Mi,
    • Catherine Law,
    • Kong-Lai Zhang,
    • Clive Osmond,
    • Claudia Stein,
    • and David Barker
    Ann Intern Med February 15, 2000 132:253-260

    This study found that infants with low birthweight were at increased risk for developing elements of the insulin resistance syndrome in adult life. This increase in risk was associated with mothers' low body mass index during pregnancy and seems independent of the offspring's high adult body mass index.

  • Screening for Hereditary Hemochromatosis in Siblings and Children of Affected Patients: A Cost-Effectiveness Analysis

    • Hashem B. El-Serag,
    • John M. Inadomi,
    • and Kris V. Kowdley
    Ann Intern Med February 15, 2000 132:261-269

    HFE gene testing for the C282Y mutation is a cost-effective method of screening relatives of patients with hereditary hemochromatosis.

  • Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study

    • A. Elisabeth Hak,
    • Huibert A.P. Pols,
    • Theo J. Visser,
    • Hemmo A. Drexhage,
    • Albert Hofman,
    • and Jacqueline C.M. Witteman
    Ann Intern Med February 15, 2000 132:270-278

    Subclinical hypothyroidism is a strong indicator of risk for atherosclerosis and myocardial infarction in elderly women.

Brief Communications

  • Positive Results on Tests for Steatorrhea in Persons Consuming Olestra Potato Chips

    • Ranga Balasekaran,
    • Jack L. Porter,
    • Carol A. Santa Ana,
    • and John S. Fordtran
    Ann Intern Med February 15, 2000 132:279-282

    Consumption of olestra can cause false-positive results on tests for steatorrhea and may therefore lead to an erroneous diagnosis of the malabsorption syndrome.

  • Fatal Hyperammonemia after Orthotopic Lung Transplantation

    • Gary R. Lichtenstein,
    • Yu-Xiao Yang,
    • Frederick A. Nunes,
    • James D. Lewis,
    • Mendel Tuchman,
    • Gregory Tino,
    • Larry R. Kaiser,
    • Harold I. Palevsky,
    • Robert M. Kotloff,
    • Emma E. Furth,
    • Joseph E. Bavaria,
    • Mark M. Stecker,
    • Paige Kaplan,
    • and Gerard T. Berry
    Ann Intern Med February 15, 2000 132:283-287

    Hyperammonemia is a potentially fatal event occurring after orthotopic lung transplantation. It is associated with concurrent medical stressors, primary pulmonary hypertension, and hepatic glutamine synthetase deficiency.

Perspectives

  • The Case for More Cautious, Patient-Focused Antiretroviral Therapy

    • Keith Henry
    Ann Intern Med February 15, 2000 132:306-311

    Many clinicians who care for patients with HIV infection are dissatisfied with the existing recommendations for antiretroviral therapy. A more cautious, patient-focused, long-term approach to therapy would help foster studies of alternate strategies, such as delayed initiation of therapy, protease inhibitor–sparing therapy, and immune-based therapy.

History of Medicine

  • Eugenic Sterilization and a Qualified Nazi Analogy: The United States and Germany, 1930-1945

    • André N. Sofair and
    • Lauris C. Kaldjian
    Ann Intern Med February 15, 2000 132:312-319

    In the United States and Germany before World War II, physicians participated in state-authorized eugenic sterilization programs in an attempt to prevent persons deemed to possess undesirable heritable characteristics from propagating. A comparison of U.S. and German histories reveals similarities that argue against easy dismissal of a Nazi analogy.

NIH Conferences

  • Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C

    • T. Jake Liang,
    • Barbara Rehermann,
    • Leonard B. Seeff,
    • and Jay H. Hoofnagle
    Ann Intern Med February 15, 2000 132:296-305

    Although the pathogenesis of liver injury caused by the hepatitis C virus (HCV) has not yet been defined, cell-mediated immune responses may be important. Chronic HCV infection is a major cause of cirrhosis, end-stage liver disease, and liver cancer. Therapy for HCV infection is still evolving, and although an HCV vaccine is not imminent, recent advances have engendered novel approaches to problems with vaccine development.

Editorial

  • Antiretroviral Therapy: Time To Think Strategically

    • Oren J. Cohen
    Ann Intern Med February 15, 2000 132:320-322

    In this issue, Henry argues the case for a more conservative, individualized approach to antiretroviral therapy and challenges some of the foundations on which guidelines have been built. Guidelines can provide useful suggestions, but decisions must be made jointly by the patient and physician after careful weighing of the risks and benefits and the patient's readiness to commit to a complex medical regimen.

On Being a Doctor

  • The Eyes of the Asp

    • Richard B. Weinberg
    Ann Intern Med February 15, 2000 132:325-326

    I knew who she was—an ASP, an Auditor for the Special Program. We had a different rendition of the acronym: A Spy Patient.

Letters

Medical Writings: Book Notes

  • Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease

    • Kenneth B. Desser
    Ann Intern Med February 15, 2000 132:332

  • Acute Respiratory Distress Syndrome: A Comprehensive Clinical Approach

    • Darryl Y. Sue
    Ann Intern Med February 15, 2000 132:332

Currents

  • The Role of Integrin-Mediated Cell Adhesion in Health and Disease: Integrin-Based Therapy in Clinical Medicine

    • Steven J. Smith
    Ann Intern Med February 15, 2000 132:333-336

Ad Libitum

Book Listings

Medical Notices

  • Medical Notices

    Ann Intern Med February 15, 2000 132:0

Summaries for Patients

  • Mother's Size during Pregnancy, Baby's Birthweight, and the Insulin Resistance Syndrome

    Ann Intern Med February 15, 2000 132:253

  • Screening the Children, Brothers, and Sisters of Persons with Hereditary Hemochromatosis

    Ann Intern Med February 15, 2000 132:261

  • Low Thyroid Function without Symptoms as a Risk Indicator for Heart Disease in Older Women

    Ann Intern Med February 15, 2000 132:270

  • Fat in the Stool of Persons Who Eat Olestra Potato Chips

    Ann Intern Med February 15, 2000 132:279

  • High Blood Ammonia Levels Are Associated with Poor Outcome after Lung Transplantation

    Ann Intern Med February 15, 2000 132:283

Updates from the Annual Session

  • Update in Critical Care Medicine

    • Kalpalatha K. Guntupalli and
    • Robert E. Fromm, Jr.
    Ann Intern Med February 15, 2000 132:288-295

    Among the topics covered in this Update are mechanical ventilation, sepsis and infection, and thromboembolism.

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This Issue

February 15, 2000; 132 (4)
  1. Articles
  2. Brief Communications
  3. Perspectives
  4. History of Medicine
  5. NIH Conferences
  6. Editorial
  7. On Being a Doctor
  8. Letters
  9. Medical Writings: Book Notes
  10. Currents
  11. Ad Libitum
  12. Book Listings
  13. Medical Notices
  14. Summaries for Patients
  15. Updates from the Annual Session

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