Table of Contents

November 16, 1999; 131 (10)

Articles

  • This study found a modest association between patient age and short-term survival of serious illness. This age effect was not explained by the current practice of providing less aggressive care to elderly patients.

  • Prophylactic fluconazole after liver transplantation decreases fungal colonization, prevents superficial and invasive fungal infections, and is not associated with appreciable hepatotoxicity. Although this therapy is related to fewer deaths from fungal infection compared with placebo, it does not improve overall survival.

  • The spectrum of neoplasms and immunosuppressive treatment with cyclosporine for chronic graft-versus-host disease as dominant risk factors indicate that immunosuppression is the major cause of malignant neoplasms in patients receiving bone marrow transplants.

  • Profiles of physician practices that base ratings of physician performance on patients' physical and mental health status are substantially affected by patients' level of education. However, these results do not suggest that physicians who care for less educated patients provide worse care. Physician profiling should account for differences in patients' level of education.

Brief Communications

  • Vitamin D receptor gene polymorphism influences bone loss after liver transplantation. Patients with the bb genotype are, to some extent, protected against post-transplantation bone loss.

  • Arthrocentesis of asymptomatic knees and first metatarsophalangeal joints and synovial fluid analysis are simple procedures that facilitate the diagnosis of gout during intercritical periods.

Updates

  • This paper discusses the rationale for a rheumatoid arthritis treatment strategy that aims to control inflammation as completely as possible; summarizes evidence from randomized, controlled clinical trials of combination disease-modifying antirheumatic drugs to control inflammation; and describes a contemporary approach to rheumatoid arthritis.

Medicine and Public Issues

  • Name-based surveillance of HIV infection is the law in 31 U.S. states, but it remains controversial. The Multistate Evaluation of Surveillance for HIV Study Group surveyed a cross-sectional probability sample of persons with AIDS in 5 states that use name-based surveillance. The results suggest that the potential for negative or positive effects of this surveillance on partner notification and access to health care has been exaggerated.

Editorial

  • Few clinical research projects have generated as much public interest or as many published articles as SUPPORT (the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment). The latest of these articles appears in this issue. What accounts for SUPPORT's impact?

On Being a Doctor

  • She walked to the door. I followed her. I had an eerie sense of predestination: If I had come to the lobby five seconds later, I would have missed her. I was meant to find her, to stop her.

On Being a Patient

  • A doctor's failing mitral valve launches a years-long search for some kind of consensus among a series of disagreeing specialists.

Letters

Medical Writings: Book Notes

Currents

Ad Libitum

Book Listings

Medical Notices

Summaries for Patients

Updates from the Annual Session

  • Among the many important topics that currently come under the heading of oncology, this Update focuses on the most common diseases: prostate cancer, breast cancer, and lung cancer.