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Effectiveness of Immunosuppressive Therapy in Older Patients with Aplastic Anemia
- André Tichelli, MD;
- Gérard Socié, MD;
- Michel Henry-Amar, MD;
- Judith Marsh, MD;
- Jakob Passweg, MD;
- Hubert Schrezenmeier, MD;
- Shaun McCann, MD;
- Jill Hows, MD;
- Per Ljungman, MD;
- Pedro Marin, MD;
- Aruna Raghavachar, MD;
- Anna Locasciulli, MD;
- Alois Gratwohl, MD;
- Andrea Bacigalupo, MD; and
- for the European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party
- From Kantonsspital Basel, Basel, Switzerland; Hôpital St. Louis, Paris, France; Centre François Baclesse, Caen, France; St. George's Hospital, London, United Kingdom; Universität Ulm, Ulm, Germany; St. James Hospital Trinity College, Dublin, Ireland; Southmead Health Services, Bristol, United Kingdom; Huddinge Hospital, Huddinge, Sweden; Postgraduate School of Haematology, Farreras Valenti, Barcelona, Spain; Ospedale San Gerardo, Monza, Italy; and Ospedale San Martino, Genova, Italy.
Abstract
Background: Immunosuppressive therapy has been used for successful treatment of severe aplastic anemia, but little information is available on outcome in older patients.
Objective: To evaluate outcome in patients older than 50 years of age who received immunosuppressive therapy for aplastic anemia.
Design: Retrospective cohort study.
Setting: 56 centers of the European Group for Blood and Marrow Transplantation (EBMT).
Patients: 810 patients with aplastic anemia reported between 1974 and 1997. Patients were evaluated according to age group: 60 years of age or older (n = 127), 50 to 59 years of age (n = 115), and 20 to 49 years of age (n = 568; reference group).
Intervention: Antilymphocyte globulin, cyclosporine, or both.
Measurements: Survival, cause of death, response to treatment, relapse rate, and risk for late complications were analyzed in all patients and by age group.
Results: The 5-year survival rate was 57% (95% CI, 46% to 66%) in patients 50 to 59 years of age and 50% (CI, 39% to 60%) in patients 60 years of age or older compared with 72% (CI, 68% to 76%) in patients younger than 50 years of age (P < 0.001). Response to therapy, relapse rate, and risk for clonal complications were similar in all three age groups (P > 0.2). Age was significantly associated with an increased risk for death (relative risk compared with patients 20 to 49 years of age, 1.80 [CI, 1.29 to 2.52] for patients 50 to 59 years of age and 2.57 [CI, 1.87 to 3.53] for patients ≥ 60 years of age), mainly because of bleeding or infection (P = 0.02). Response to immunosuppressive therapy in all patients at 12 months was 62% (CI, 58% to 66%); no difference was seen among the age groups in multivariate analysis (P > 0.2). Sixty-six of the 379 responding patients (17%) subsequently had relapse. The risk for clonal disorders at 10 years was 20% (CI, 15% to 27%).
Conclusions: Response to immunosuppression in aplastic anemia is independent of age, but treatment is associated with increased mortality in older patients.
- Anemia, aplastic
- Immunosuppression
- Outcome and process assessment (health care)
- Age factors
- Immunosuppressive agents
Article and Author Information
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Requests for Reprints: André Tichelli, Hämatologielabor, Departement Zentrallabor, Kantonsspital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
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Current Author Addresses: Drs. Tichelli, Passweg, and Gratwohl: Hämatologielabor, Departement Zentrallabor, Kantonsspital Basel, CH-4031 Basel, Switzerland.
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Dr. Socié: Bone Marrow Transplant Unit, Hôpital St. Louis, 75475 Paris Cedex 10, France.
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Dr. Henry-Amar, Centre François Baclesse, BP 5026, F-14076 Caen Cedex 5, France.
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Dr. Marsh: Division of Haematology, St. George's Hospital, London SW17 ORE, United Kingdom.
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Drs. Schrezenmeier and Rhagavachar: Hämatologie, Abteilung Innere Medizin, Universität Ulm, D-89081 Ulm, Germany.
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Dr. McCann: St. James Hospital Trinity College, Dublin 8, Ireland.
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Dr. Hows: Department of Transplantation Sciences, Southmead Health Services, Bristol BS10 5NB, United Kingdom.
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Dr. Ljungman: Department of Medicine, Huddinge Hospital, S-14186 Huddinge, Sweden.
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Dr. Marin: Postgraduate School of Haematology, Farreras Valenti, E-08036 Barcelona, Spain.
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Dr. Locasciulli: Clinica Pediatrica, Ospedale San Gerardo, I-20052 Monza, Italy.
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Dr. Bacigalupo: Centro Trapianti di Midollo Osseo, Divisione di Ematologia, Ospedale San Martino, I-16132 Genova, Italy.
- Copyright ©2004 by the American College of Physicians
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