Table of Contents

June 15, 1999; 130 (12)

Articles

  • HFE Genotype in Patients with Hemochromatosis and Other Liver Diseases

    • Bruce R. Bacon,
    • John K. Olynyk,
    • Elizabeth M. Brunt,
    • Robert S. Britton,
    • and Roger K. Wolff
    Ann Intern Med June 15, 1999 130:953-962

    In this study, all patients homozygous for the C282Y mutation of HFE had an elevated hepatic iron concentration, but approximately 15% of these patients did not meet a previous diagnostic criterion for hemochromatosis. Determination of HFE genotype is clinically useful in patients with liver disease and suspected iron overload and may lead to identification of otherwise unsuspected C282Y homozygotes.

  • Relation of Consumption of Vitamin E, Vitamin C, and Carotenoids to Risk for Stroke among Men in the United States

    • Alberto Ascherio,
    • Eric B. Rimm,
    • Miguel A. Hernán,
    • Edward Giovannucci,
    • Ichiro Kawachi,
    • Meir J. Stampfer,
    • and Walter C. Willett
    Ann Intern Med June 15, 1999 130:963-970

    Vitamin E and vitamin C supplements and specific carotenoids did not seem to cause a substantially reduced risk for stroke in a cohort of 40- to 75-year-old men who did not have a history of cardiovascular disease or diabetes.

  • A Molecular Epidemiologic Analysis of Tuberculosis Trends in San Francisco, 1991–1997

    • Robert M. Jasmer,
    • Judith A. Hahn,
    • Peter M. Small,
    • Charles L. Daley,
    • Marcel A. Behr,
    • Andrew R. Moss,
    • Jennifer M. Creasman,
    • Gisela F. Schecter,
    • E. Antonio Paz,
    • and Philip C. Hopewell
    Ann Intern Med June 15, 1999 130:971-978

    During a 6-year period in San Francisco, the rates of tuberculosis cases and clustered tuberculosis cases decreased both overall and among persons in high-risk groups. This occurred in a period during which tuberculosis control measures were intensified.

  • Translating Clinical Trial Results into Practice: The Effect of an AIDS Clinical Trial on Prescribed Antiretroviral Therapy for HIV-Infected Pregnant Women

    • Barbara J. Turner,
    • Craig J. Newschaffer,
    • Daozhi Zhang,
    • Thomas Fanning,
    • and Walter W. Hauck
    Ann Intern Med June 15, 1999 130:979-986

    The success of Pediatric AIDS Clinical Trials Group 076 in preventing vertical HIV transmission prompted intensive efforts to inform lay persons and professionals about the trial's results. Community practices responded rapidly to efforts to disseminate these results. However, the absolute increase in prescribed therapy was greatest for women who had adequate prenatal visits or were receiving HIV-focused care, care at a site that conducted clinical trials, or methadone therapy.

Brief Communications

  • Effects of Leisure-Time Physical Activity and Ventilatory Function on Risk for Stroke in Men: The Reykjavík Study

    • Uggi Agnarsson,
    • Gudmundur Thorgeirsson,
    • Helgi Sigvaldason,
    • and Nikulas Sigfusson
    Ann Intern Med June 15, 1999 130:987-990

    Middle-aged men who participate in leisure-time physical activity and have good pulmonary function seem to have a lower risk for stroke than men who are not active or have diminished pulmonary function.

  • Effect of Nasogastric Tube Size on Gastroesophageal Reflux and Microaspiration in Intubated Patients

    • Miquel Ferrer,
    • Torsten Thomas Bauer,
    • Antoni Torres,
    • Carmen Hernández,
    • and Carlos Piera
    Ann Intern Med June 15, 1999 130:991-994

    Small-bore nasogastric tubes in intubated patients did not reduce the rate of gastroesophageal reflux or microaspiration.

Academia and Clinic

  • Toward Evidence-Based Medical Statistics. 1: The P Value Fallacy

    • Steven N. Goodman
    Ann Intern Med June 15, 1999 130:995-1004

    An important problem exists in the interpretation of modern medical research data: Biological understanding and previous research play little formal role in the interpretation of quantitative results. The first of a pair of articles on evidence-based statistics outlines how the standard statistical approach has created this situation by promoting the illusion that conclusions that have certain “error rates” can be produced without consideration of information from outside the experiment.

  • Toward Evidence-Based Medical Statistics. 2: The Bayes Factor

    • Steven N. Goodman
    Ann Intern Med June 15, 1999 130:1005-1013

    The second article on evidence-based statistics explores the inductive Bayesian approach to measuring evidence and combining information and addresses the epistemologic uncertainties that affect all statistical approaches to inference.

Perspectives

  • An Association for Patient-Oriented Research

    • Jules Hirsch
    Ann Intern Med June 15, 1999 130:1014-1017

    The number of physician-scientists, who study the pathogenesis of disease by using both bedside observations and modern laboratory techniques, is decreasing. This paper discusses the continuing need for physician-scientists and introduces a new professional organization, the Association for Patient-Oriented Research.

Editorials

  • Will the Real Hemochromatosis Please Stand Up?

    • Adele L. Franks and
    • Wylie Burke
    Ann Intern Med June 15, 1999 130:1018-1019

    The recent identification of two HFE gene mutations associated with hereditary hemochromatosis raised hope that genotyping could resolve the diagnostic uncertainty in early stages of the disease. In this issue, Bacon and colleagues explore the utility of genetic testing in referral patients with known or suspected hereditary hemochromatosis and other liver diseases. What implications do the results of this research have for the use of genetic testing during routine evaluation for hereditary hemochromatosis?

  • Standing Statistics Right Side Up

    • Frank Davidoff
    Ann Intern Med June 15, 1999 130:1019-1021

    In this issue, Goodman demonstrates how the standard statistical methods used to analyze biomedical research, which we have come to accept as a kind of revealed truth, stand statistical inference on its head.

On Being a Doctor

  • Same Old Seventeen-Dollar Lamps

    • Timothy E. Quill
    Ann Intern Med June 15, 1999 130:1022-1024

    What can near-death experiences teach the physicians who care for dying patients?

On Being a Patient

  • The Ritual

    • Thomas V. Nowak
    Ann Intern Med June 15, 1999 130:1025-1026

    “Of all the medicines your mother takes,” Dr. Gorman said, “the morphine is the most important.  … The point is, there just isn't any need for her to feel pain.”

Letters

  • Subcutaneous Heparin for Deep Venous Thrombosis

    • Adriano Alatri,
    • Paolo Bucciarelli,
    • and Marco Moia
    Ann Intern Med June 15, 1999 130:1027

  • Subcutaneous Heparin for Deep Venous Thrombosis

    • Paolo Prandoni
    Ann Intern Med June 15, 1999 130:1027

  • Ventilator-Associated Pneumonia in Critically Ill Patients

    • Bruce Kramer
    Ann Intern Med June 15, 1999 130:1027-1028

  • Ventilator-Associated Pneumonia in Critically Ill Patients

    • Deborah Cook
    Ann Intern Med June 15, 1999 130:1028

  • Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure

    • Moses S. Elisaf,
    • Haralampos J. Millionis,
    • and Kostas C. Siamopoulos
    Ann Intern Med June 15, 1999 130:1028

  • Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure

    • José J.G. De Lima
    Ann Intern Med June 15, 1999 130:1028

  • Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure

    • Leonardo A. Sechi,
    • Laura Zingaro,
    • and Ettore Bartoli
    Ann Intern Med June 15, 1999 130:1028-1029

  • Recurrent Human Granulocytic Ehrlichiosis and Lyme Disease

    • James R. Johnson
    Ann Intern Med June 15, 1999 130:1029

  • Recurrent Human Granulocytic Ehrlichiosis and Lyme Disease

    • Harold W. Horowitz,
    • Maria E. Aguero-Rosenfeld,
    • and Gary P. Wormser
    Ann Intern Med June 15, 1999 130:1029-1030

  • Ferrous Sulfate Tolerance Test: A Case Report

    • Omaya H. Youssef,
    • Almond J. Drake III,
    • and K.M. Mohamed Shakir
    Ann Intern Med June 15, 1999 130:1030

  • Weighing the Alternatives

    • Kenneth D. Gardner, Jr.
    Ann Intern Med June 15, 1999 130:1030

  • Correction: Book Note

    Ann Intern Med June 15, 1999 130:1030

Medical Writings: Book Notes

  • 20 Common Problems in Primary Care

    • Michael B. Steinberg
    Ann Intern Med June 15, 1999 130:1031

  • Clinical Management of Infectious Diseases: A Guide to Diagnosis and Therapy

    • J. V. Hirschmann
    Ann Intern Med June 15, 1999 130:1031-1032

  • CPR: Resuscitation of the Arrested Heart

    • Sheldon L. Brownstein
    Ann Intern Med June 15, 1999 130:1032

  • Low Back Pain Handbook

    • John D. Loeser
    Ann Intern Med June 15, 1999 130:1032

Currents

  • Nutrition and Policy. 3: Food Industry Response to Nutritional Standards

    • Aaron Levin
    Ann Intern Med June 15, 1999 130:1033-1036

  • Have Oxygen, Will Travel

    • Francie Scott
    Ann Intern Med June 15, 1999 130:1036

Book Listings

Medical Notices

  • Medical Notices

    Ann Intern Med June 15, 1999 130:0
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This Issue

June 15, 1999; 130 (12)
  1. Articles
  2. Brief Communications
  3. Academia and Clinic
  4. Perspectives
  5. Editorials
  6. On Being a Doctor
  7. On Being a Patient
  8. Letters
  9. Medical Writings: Book Notes
  10. Currents
  11. Book Listings
  12. Medical Notices

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