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Extrahepatic Manifestations of Hepatitis C Virus Infection
- Jose Luis Perez-Castrillon, MD; and
- Miguel Martin-Luguero, MD
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TO THE EDITOR:
Gumber and Chopra [1] wrote an excellent review of extrahepatic manifestations of HCV infection. However, the review does not mention the association between HCV infection and B-cell non-Hodgkin lymphoma.
Ferri and colleagues [2] showed the presence of HCV infection in 17 patients (30%) of 50 unselected patients with B-cell non-Hodgkin lymphoma. Cryoglobulinemia was detected in 8% of these patients. This association is particularly significant compared with the prevalence of HCV infection in the healthy Italian population (1.3%). Pozzato and associates [3] showed a high prevalence of non-Hodgkin lymphoma in patients with cryoglobulinemia and HCV infection. The presence of viral genome in peripheral lymphocytes [4] suggests that the HCV genome is directly involved in the lymphoproliferative process that leads to lymphoma.
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
- Copyright ©2004 by the American College of Physicians
