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Advances in the Management of AIDS-Related Cytomegalovirus Retinitis
- Henry Masur, MD;
- Scott M. Whitcup, MD;
- Charles Cartwright, PhD;
- Michael Polis, MD; and
- Robert Nussenblatt, MD
- Moderator: Masur, Henry MD; Discussants: Whitcup, Scott M. MD; Cartwright, Charles PhD; Polis, Michael MD; Nussenblatt, Robert MD An edited and updated summary of a conference held on 18 October 1995 at the Clinical Center of the National Institutes of Health, Bethesda, Maryland. Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of the reference: Whitcup SM. Diagnosis, screening, and prognosis, pp 127-128. In: Masur H, moderator. Advances in the management of AIDS-related cytomegalovirus retinitis. Ann Intern Med. 1996; 125:126-136 Requests for Reprints: Henry Masur, MD, Critical Care Medicine Department, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892. Current Author Addresses: Dr. Masur: Critical Care Medicine Department, National Institutes of Health, Building 10, Room 7D43, Bethesda, MD 20892.
Abstract
Cytomegalovirus (CMV) retinitis, a common complication of the acquired immunodeficiency syndrome (AIDS), is increasing in frequency as patients infected with the human immunodeficiency virus (HIV) live longer.In recent years, the lifetime risk for CMV disease in HIV-infected persons has increased from 24.9% to 44.9%. Cytomegalovirus retinitis is usually diagnosed clinically: Almost all patients are CMV seropositive and have CD4+ counts less than 50 cells/mm3. Specific diagnostic tests that use antigen detection or quantitation of circulating nucleic acid to detect CMV are being developed, but they have not been validated for routine clinical use. Such tests would help predict disease, diagnose acute retinitis, and monitor therapy.
- Copyright ©2004 by the American College of Physicians
