Thrombolytic Treatment and Balloon Angioplasty in Chronic Occlusion of the Aortic Bifurcation

  1. Ernst Pilger, MD;
  2. Martin Decrinis, MD;
  3. Gerhard Stark, MD;
  4. Gunther Koch, MD;
  5. Andrea Obernosterer, MD;
  6. Robert Tischler, MD;
  7. Marianne Lafer, MD; and
  8. Alexander Doder, MD
  1. From Karl-Franzens-University, Graz, Austria. Requests for Reprints: Ernst Pilger, MD, Division of Angiology, Department of Internal Medicine, Karl-Franzens-University, Auenbruggerplatz 15, A-8036 Graz, Austria.

    Abstract

    Objective: To evaluate nonsurgical alternatives in reopening chronically occluded aortic bifurcation.

    Design: Uncontrolled randomized study.

    Setting: University-affiliated referral center for vascular diseases.

    Patients: Twenty-five of 39 consecutive patients with chronic aortoiliac disease including a totally occluded aortic bifurcation were found to be acceptable candidates for an aortobifemoral prosthetic graft.

    Intervention: Patients were randomly assigned to receive either streptokinase or urokinase or recombinant tissue-type plasminogen activator (rt-PA). In cases of successful thrombolysis and residual obstructions, subsequent balloon angioplasty was attempted. Prosthetic bypass grafting was done if thrombolytic treatment and balloon angioplasty failed.

    Results: Complete lysis was achieved in 5 of 25 patients (20%). In 10 (40%) patients, lysis showed residual obstructions, which were reopened mechanically in 8 patients; 2 patients had extra-anatomical bypass grafts. Ten patients (40%) without thrombolysis had surgical aortobifemoral bypass grafts. Overall, recanalization and clinical improvement were achieved in 13 of 25 patients (52%) by thrombolytic therapy and subsequent balloon angioplasty. The recanalization rate did not differ among the different thrombolytic drugs. However, rt-PA therapy resulted in reopening after 4 days of treatment; streptokinase, after 6 days; and urokinase, after 9 days (P < 0.005). No major complications or deaths occurred.

    Conclusion: Thrombolytic treatment followed by balloon angioplasty may help avoid the need for aortobifemoral prosthetic bypass grafting in more than 50% of patients with chronic aortoiliac disease.

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    1. Ann Intern Med January 1, 1994 vol. 120 no. 1 40-44
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