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Anesthesia Not Related to Fludarabine Toxicity
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
Include no more than 300 words of text, three authors, and five references
Type with double-spacing
Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
TO THE EDITOR:
I read with interest the brief report by Cohen and colleagues [1] about reversible neurologic toxicity associated with fludarabine. What caught my eye was the statement that general anesthesia (Patient 2) may have potentiated fludarabine toxicity. The authors note that the surgery in Patient 2 was brief, limited in scope, and uncomplicated.
I generally appreciate the contribution of the medical evaluation in complex perioperative patients, but some internists' recommendations can be irritating and can have medicolegal implications [2]. I pose this question to Dr. Cohen and his coworkers: Are there specific data concerning fludarabine and anesthesia to support their statements or is this simply conjecture?
Kenneth E. Shepherd
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
Include no more than 300 words of text, three authors, and five references
Type with double-spacing
Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
- Copyright 2004 by the American College of Physicians
