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New Insights into Common Variable Immunodeficiency
- Michael C. Sneller, MD;
- Warren Strober, MD;
- Eli Eisenstein, MD;
- Jonathan S. Jaffe, MD; and
- Charlotte Cunningham-Rundles, MD, PhD
- An edited summary of a Clinical Staff Conference held 29 April 1992 at the Amphitheater, Building 10, Bethesda, Maryland. The conference was sponsored by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and the Center for Biologics Evaluation and Research, Food and Drug Administration, U.S. Department of Health and Human Services. Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of reference: Strober W. Immunologic and genetic studies in common variable immunodeficiency, pp 722-724. In: Sneller MC, moderator. New insights into common variable immunodeficiency. Ann Intern Med. 1993; 118:720-730. Requests for Reprints: Warren Strober, MD, National Institute of Allergy and Infectious Diseases, Building 10, Room 11N250, 9000 Rockville Pike, Bethesda, MD 20892.
Abstract
Common variable immunodeficiency (CVI) is a heterogenous immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and various immunologic abnormalities. In addition to recurrent infections, patients with this syndrome also have an increased incidence of autoimmune disease and malignancy. Because the spectrum of associated diseases is broad, patients with CVI are seen by various medical specialists. This review discusses the pathogenesis, clinical manifestations, diagnosis, and treatment of CVI.
- Copyright 2004 by the American College of Physicians
