Microalbuminuria, Lipoproteins, and Diabetic Control
- Connie L. Manske, MD
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TO THE EDITOR:
Ramirez and colleagues [1] have shown a relation between high Lp(a) levels and poor glycemic control in diabetic patients. They did not, however, include data on a major potential confounding factor—urinary protein excretion. Several investigators have documented a dramatic increase in Lp(a) levels in nondiabetic patients with heavy proteinuria as well as in diabetic patients with microalbuminuria [2-4]. Because the presence of diabetic nephropathy correlates with poor glycemic control [5], proteinuria was probably more prevalent in the patients with HbA1c levels greater than 8%. Does the association of poor glycemic control and high Lp(a) levels persist after controlling for elevated urinary protein excretion?
Connie L. Manske
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
•Include no more than 300 words of text, three authors, and five references
•Type with double-spacing
•Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
- Copyright ©2004 by the American College of Physicians
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