In making its recommendation on screening for type 2 diabetes, the USPSTF considered interventions, including lipid-lowering agents, for effects on such health outcomes as cardiovascular events. In reviewing the evidence on lipid-lowering agents, the USPSTF found that persons with diabetes do not seem to benefit to a greater extent than those without for the primary prevention of cardiovascular events, whether considering absolute or relative risk reduction. For example, in the Heart Protection Study, the absolute reduction in coronary events for participants receiving simvastatin versus placebo was similar in those with and without diabetes: 3.2% and 3.0%, respectively (calculated from data in the Heart Protection Study) (1). Therefore, the evidence does not support screening for type 2 diabetes on the basis of lipid status. However, the USPSTF encourages clinicians to perform a global cardiovascular disease risk assessment to determine a person's 10-year cardiovascular disease risk (2) and to screen for type 2 diabetes if knowledge of diabetes status would change management, including the management of hypertension or the use of lipid-lowering agents and aspirin.