 |
 |
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
21 October 2003 | Volume 139 Issue 8 | Pages 642-648
Background: Several experimental investigations have emphasized the favorable effects of insulin-like growth factor I (IGF-I) on left ventricular remodeling, partly through its antiapoptotic effects. Cross-sectional clinical studies have reported that low serum IGF-I levels in patients with heart failure correlate with cachexia and severity of ventricular dysfunction. It is unclear whether low serum IGF-I is a risk factor for heart failure.
Objective: To prospectively study the association between serum IGF-I level and the incidence of congestive heart failure.
Design: Community-based, prospective cohort study.
Setting: Framingham, Massachusetts.
Participants: 717 elderly individuals (mean age, 78.4 years; 67% women) who did not have myocardial infarction and congestive heart failure at baseline.
Measurement: Incidence of a first episode of congestive heart failure on follow-up.
Results: During follow-up (mean, 5.2 years), 56 participants (35 women) developed congestive heart failure. In multivariable Cox regression models adjusting for established risk factors at baseline, there was a 27% decrease in risk for heart failure for every 1 standard deviation increment in log IGF-I. Individuals with serum IGF-I level at or above the median value (140 µg/L) had half the risk for heart failure (hazard ratio, 0.49 [95% CI, 0.26 to 0.92]) of those with serum IGF-I levels below the median. These comparisons were maintained in analyses adjusting for the occurrence of a myocardial infarction on follow-up.
Conclusions: In our prospective, community-based investigation, serum IGF-I level was inversely related to the risk for congestive heart failure in elderly people without a previous myocardial infarction. Additional investigations are warranted to confirm these findings.
Editors' Notes
Context
Contribution
Implications
Cautions
–The Editors
Author and Article Information
From the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts; Boston University and Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts; and National Institute on Aging and National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Grant Support: In part by National Institutes of Health (NIH) and National Heart, Lung, and Blood Institute (NHLBI) contract N01-HC-25195, NHLBI grant 1K24 HL04334 (Dr. Vasan), NIH and U.S. Department of Agriculture interagency agreement Y01-AG-4-0245 (Dr. Roubenoff), and NIH grants DK02120 (Dr. Roubenoff) and AG15797 (Dr. Roubenoff).
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Ramachandran S. Vasan, MD, The Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5803.
Current Author Addresses: Drs. Vasan and Levy: 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5803.
Drs. Sullivan and D'Agostino: 111 Cummington Street, Boston, MA 02215.
Dr. Roubenoff: 75 Sidney Street, Cambridge, MA 02134.
Dr. Harris: 7201 Wisconsin Avenue, Bethesda, MD 20892-9205.
Drs. Sawyer and Wilson: 715 Albany Street, Boston, MA 02118.
Author Contributions: Conception and design: R.S. Vasan, R.B. D'Agostino, R. Roubenoff, D. Levy.
Analysis and interpretation of the data: R.S. Vasan, L.M. Sullivan, R.B. D'Agostino, D.B. Sawyer, D. Levy, P.W.F. Wilson.
Drafting of the article: R.S. Vasan, L.M. Sullivan, D.B. Sawyer, D. Levy.
Critical revision of the article for important intellectual content: R.S. Vasan, L.M. Sullivan, R.B. D'Agostino, D.B. Sawyer, D. Levy, P.W.F. Wilson.
Final approval of the article: R.S. Vasan, L.M. Sullivan, R.B. D'Agostino, T. Harris, D. Levy, P.W.F. Wilson.
Provision of study materials or patients: R. Roubenoff, T. Harris.
Statistical expertise: L.M. Sullivan.
Obtaining of funding: R. Roubenoff, T. Harris.
Administrative, technical, or logistic support: T. Harris, D. Levy, P.W.F. Wilson.
Collection and assembly of data: T. Harris. ARTICLE
Serum Insulin-like Growth Factor I and Risk for Heart Failure in Elderly Individuals without a Previous Myocardial Infarction: The Framingham Heart Study
Related articles in Annals:
This article has been cited by other articles:
|
|
 |
|
  M. Andreassen, I. Raymond, C. Kistorp, P. Hildebrandt, J. Faber, and L. O. Kristensen IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population Eur. J. Endocrinol., January 1, 2009; 160(1): 25 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Colao, C. Di Somma, T. Cascella, R. Pivonello, G. Vitale, L. F S Grasso, G. Lombardi, and S. Savastano Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects Eur. J. Endocrinol., October 1, 2008; 159(4): 389 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Groban, H. Jobe, M. Lin, T. Houle, D. A. Kitzman, and W. Sonntag Effects of Short-Term Treadmill Exercise Training or Growth Hormone Supplementation on Diastolic Function and Exercise Tolerance in Old Rats J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2008; 63(9): 911 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Colao, C. Di Somma, S. Spiezia, S. Savastano, F. Rota, M. C. Savanelli, and G. Lombardi Growth Hormone Treatment on Atherosclerosis: Results of a 5-Year Open, Prospective, Controlled Study in Male Patients with Severe Growth Hormone Deficiency J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3416 - 3424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Y. Oudit, Z. Kassiri, J. Zhou, Q. C. Liu, P. P. Liu, P. H. Backx, F. Dawood, M. A. Crackower, J. W. Scholey, and J. M. Penninger Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress Cardiovasc Res, June 1, 2008; 78(3): 505 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Schocken, E. J. Benjamin, G. C. Fonarow, H. M. Krumholz, D. Levy, G. A. Mensah, J. Narula, E. S. Shor, J. B. Young, and Y. Hong Prevention of Heart Failure: A Scientific Statement From the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, May 13, 2008; 117(19): 2544 - 2565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gonzalez, M. Rota, D. Nurzynska, Y. Misao, J. Tillmanns, C. Ojaimi, M. E. Padin-Iruegas, P. Muller, G. Esposito, C. Bearzi, et al. Activation of Cardiac Progenitor Cells Reverses the Failing Heart Senescent Phenotype and Prolongs Lifespan Circ. Res., March 14, 2008; 102(5): 597 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sukhanov, Y. Higashi, S.-Y. Shai, C. Vaughn, J. Mohler, Y. Li, Y.-H. Song, J. Titterington, and P. Delafontaine IGF-1 Reduces Inflammatory Responses, Suppresses Oxidative Stress, and Decreases Atherosclerosis Progression in ApoE-Deficient Mice Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2684 - 2690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saydah, B. Graubard, R. Ballard-Barbash, and D. Berrigan Insulin-like Growth Factors and Subsequent Risk of Mortality in the United States Am. J. Epidemiol., September 1, 2007; 166(5): 518 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Berrigan, N. Potischman, K. W. Dodd, M. Nicar, G. McQuillan, J. A. Lavigne, J. C. Barrett, and R. Ballard-Barbash Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor-I Binding Protein-3: Quality Control for Studies of Stored Serum Cancer Epidemiol. Biomarkers Prev., May 1, 2007; 16(5): 1017 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Tran, C. Diorio, S. Berube, M. Pollak, and J. Brisson Relation of insulin-like growth factor (IGF) I and IGF-binding protein 3 concentrations with intakes of fruit, vegetables, and antioxidants Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1518 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yazdanpanah, F. A Sayed-Tabatabaei, J. A M J L Janssen, I. Rietveld, A. Hofman, T. Stijnen, H. A P Pols, S. W J Lamberts, J. C M Witteman, and C. M van Duijn IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes. Eur. J. Endocrinol., November 1, 2006; 155(5): 751 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Jankowska, B. Biel, J. Majda, A. Szklarska, M. Lopuszanska, M. Medras, S. D. Anker, W. Banasiak, P. A. Poole-Wilson, and P. Ponikowski Anabolic Deficiency in Men With Chronic Heart Failure: Prevalence and Detrimental Impact on Survival Circulation, October 24, 2006; 114(17): 1829 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Abe, T. Matsunaga, K. Kameda, H. Tomita, T. Fujiwara, H. Ishizaka, H. Hanada, K. Fukui, I. Fukuda, T. Osanai, et al. Increased Level of Pericardial Insulin-Like Growth Factor-1 in Patients With Left Ventricular Dysfunction and Advanced Heart Failure J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1387 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Efstratiadis, G. Tsiaousis, V. G. Athyros, D. Karagianni, A. Pavlitou-Tsiontsi, A. Giannakou-Darda, and C. Manes Total Serum Insulin-like Growth Factor-1 and C-Reactive Protein in Metabolic Syndrome With or Without Diabetes Angiology, May 1, 2006; 57(3): 303 - 311. [Abstract] [PDF]
|
|
|
|
|
|
B. E. Engstrom, P. Burman, C. Holdstock, M. Ohrvall, M. Sundbom, and F A. Karlsson Effects of gastric bypass on the GH/IGF-I axis in severe obesity - and a comparison with GH deficiency Eur. J. Endocrinol., January 1, 2006; 154(1): 53 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Groban, N. A. Pailes, C. D. L. Bennett, C. S. Carter, M. C. Chappell, D. W. Kitzman, and W. E. Sonntag Growth Hormone Replacement Attenuates Diastolic Dysfunction and Cardiac Angiotensin II Expression in Senescent Rats J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2006; 61(1): 28 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Johnsen, H. H. Hundborg, H. T. Sorensen, H. Orskov, A. Tjonneland, K. Overvad, and J. O. L. Jorgensen Insulin-Like Growth Factor (IGF) I, -II, and IGF Binding Protein-3 and Risk of Ischemic Stroke J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 5937 - 5941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Anversa Aging and Longevity: The IGF-1 Enigma Circ. Res., September 2, 2005; 97(5): 411 - 414. [Full Text] [PDF]
|
|
|
|
|
|
A. Colao, C. Di Somma, F. Rota, S. Di Maio, M. Salerno, A. Klain, S. Spiezia, and G. Lombardi Common Carotid Intima-Media Thickness in Growth Hormone (GH)-Deficient Adolescents: A Prospective Study after GH Withdrawal and Restarting GH Replacement J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2659 - 2665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Colao, C. Di Somma, F. Rota, R. Pivonello, M. C. Savanelli, S. Spiezia, and G. Lombardi Short-Term Effects of Growth Hormone (GH) Treatment or Deprivation on Cardiovascular Risk Parameters and Intima-Media Thickness at Carotid Arteries in Patients with Severe GH Deficiency J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2056 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A R Hayati, F C Cheah, J F Yong, A E Tan, and W M Norizah The role of serum insulin-like growth factor I (IGF-I) in neonatal outcome J. Clin. Pathol., December 1, 2004; 57(12): 1299 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Conti, C. Carrozza, E. Capoluongo, M. Volpe, F. Crea, C. Zuppi, and F. Andreotti Insulin-Like Growth Factor-1 as a Vascular Protective Factor Circulation, October 12, 2004; 110(15): 2260 - 2265. [Full Text] [PDF]
|
|
|
|
|
|
D. Torella, M. Rota, D. Nurzynska, E. Musso, A. Monsen, I. Shiraishi, E. Zias, K. Walsh, A. Rosenzweig, M. A. Sussman, et al. Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression Circ. Res., March 5, 2004; 94(4): 514 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Is a Low IGF-I Level a Heart-Failure Risk Factor? Journal Watch Cardiology, January 16, 2004; 2004(116): 6 - 6. [Full Text]
|
|
Article
